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Most Influential CLINICAL GASTROENTEROLOGY AND HEPATOLOGY Papers

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Clinical Gastroenterology and Hepatology is a monthly peer-reviewed medical journal published by Elsevier on behalf of the American Gastroenterological Association. Paper Digest Team analyze all papers published on CLINICAL GASTROENTEROLOGY AND HEPATOLOGY in the past years, and presents the 10 most influential papers for each year (based on when the paper became available online). This ranking list is automatically constructed based upon citations from both research papers and granted patents, and will be frequently updated to reflect the most recent changes. To find the most influential papers from other conferences/journals, visit Best Paper Digest page. Note: the most influential papers may or may not include the papers that won the best paper awards. (Last updated on: 2021-05-23)

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TABLE 1: Most Influential CLINICAL GASTROENTEROLOGY AND HEPATOLOGY Papers

Year Rank Paper Author(s)
2020 1 Clinical Features of COVID-19-Related Liver Functional Abnormality
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Abstract: Some patients with SARS-CoV-2 infection have abnormal liver function. We aimed to clarify the features of COVID-19-related liver damage to provide references for clinical …		 ZHENYU FAN et. al.
2020 2 Diarrhea During COVID-19 Infection: Pathogenesis, Epidemiology, Prevention, and Management
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Abstract: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2/COVID-19) pandemic is a worldwide emergency. An increasing number of diarrhea cases is reported. Here we …		 Ferdinando D’Amico; Daniel C Baumgart; Silvio Danese; Laurent Peyrin-Biroulet;
2020 3 Don’t Overlook Digestive Symptoms in Patients With 2019 Novel Coronavirus Disease (COVID-19)
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 Shihua Luo; Xiaochun Zhang; Haibo Xu;
2020 4 ACE2 Expression in Pancreas May Cause Pancreatic Damage After SARS-CoV-2 Infection
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Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel coronavirus that causes coronavirus disease 2019 (COVID-19) in human beings, has caused a serious public …		 FURONG LIU et. al.
2020 5 Crohn’s Disease of The Esophagus
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 Amrit K Kamboj; Sunanda V Kane; Cadman L Leggett;
2020 6 Diarrhea Is Associated With Prolonged Symptoms and Viral Carriage in Corona Virus Disease 2019
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Abstract: We compared clinical, laboratory, radiological, and outcome features of patients with SARS-CoV-2 infection (COVID-19) with pneumonia, with vs without diarrhea. We performed a …		 XIAO-SHAN WEI et. al.
2020 7 Incidence and Patterns of COVID-19 Among Inflammatory Bowel Disease Patients From The Nancy and Milan Cohorts
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Abstract: The first cases of COVID-19 infection were reported in December, 2019, in Wuhan, China. Italy (in particular Lombardy) and France (in particular Northeast) have been gravely hit. …		 MARIANGELA ALLOCCA et. al.
2020 8 What Should Gastroenterologists and Patients Know About COVID-19?
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 Ryan C Ungaro; Timothy Sullivan; Jean-Frederic Colombel; Gopi Patel;
2020 9 Reply
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 Nicole J Kim; George N Ioannou;
2020 10 Maintaining The Quality Standards of Care for Inflammatory Bowel Disease Patients During The COVID-19 Pandemic
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Abstract: Since February 20, 2020, the SARS-COV2 infection has spread in Lombardy, and in the rest of the Italian regions, forcing our government to impose a national lockdown. Hospitals …		 MARIANGELA ALLOCCA et. al.
2019 1 Burden of Gastric Cancer
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Abstract: Gastric cancer is a global health problem, with more than 1 million people newly diagnosed with gastric cancer worldwide each year. Despite its worldwide decline in incidence and …		 Aaron P Thrift; Hashem B El-Serag;
2019 2 Contemporary Epidemiology of Chronic Liver Disease and Cirrhosis
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Abstract: Accurate estimates for the contemporary burden of chronic liver disease (CLD) are vital for setting clinical, research, and policy priorities. We aimed to review the incidence, …		 Andrew M Moon; Amit G Singal; Elliot B Tapper;
2019 3 Appropriate Therapeutic Drug Monitoring Of Biologic Agents For Patients With Inflammatory Bowel Diseases
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Abstract: Therapeutic drug monitoring (TDM) is widely available for biologic therapies in patients with inflammatory bowel disease (IBD). We reviewed current data and provided expert …		 KONSTANTINOS PAPAMICHAEL et. al.
2019 4 Comparative Risk of Serious Infections With Biologic And/or Immunosuppressive Therapy in Patients With Inflammatory Bowel Diseases: A Systematic Review and Meta-Analysis
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Abstract: We performed a systematic review and meta-analysis to evaluate the comparative risk of serious infections with tumor necrosis factor (TNF) antagonists, non-TNF targeted biologics, …		 Siddharth Singh; Antonio Facciorusso; Parambir S Dulai; Vipul Jairath; William J Sandborn;
2019 5 Diagnostic Accuracy Of Noninvasive Fibrosis Models To Detect Change In Fibrosis Stage
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Abstract: Noninvasive methods are needed to determine disease stage in patients with nonalcoholic fatty liver disease (NAFLD). We evaluated the diagnostic performance of several widely …		 MOHAMMAD SHADAB SIDDIQUI et. al.
2019 6 Artificial Intelligence-assisted System Improves Endoscopic Identification of Colorectal Neoplasms
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Abstract: Precise optical diagnosis of colorectal polyps could improve the cost-effectiveness of colonoscopy and reduce polypectomy-related complications. However, it is difficult for …		 SHIN-EI KUDO et. al.
2019 7 Efficacy and Safety of Endoscopic Sleeve Gastroplasty: A Systematic Review and Meta-Analysis
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Abstract: Bariatric surgery is the most successful treatment for obesity. However, many patients avoid surgery due to its perceived invasive nature and fear of complications. Endoscopic …		 ABDELLAH HEDJOUDJE et. al.
2019 8 Effects of Fecal Microbiota Transplantation With Oral Capsules in Obese Patients
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Abstract: Studies in mice have shown that the intestinal microbiota can contribute to obesity via the anorexigenic gut hormone glucagon-like peptide 1 (GLP1) and bile acids, which affect …		 JESSICA R ALLEGRETTI et. al.
2019 9 Cost-Effectiveness Of Colorectal Cancer Screening Strategies-A Systematic Review
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Abstract: Widespread screening for colorectal cancer (CRC) has reduced its incidence and mortality. Previous studies investigated the economic effects of CRC screening. We performed a …		 TAO RAN et. al.
2019 10 Safety Of Biologic Therapy In Older Patients With Immune-Mediated Diseases: A Systematic Review And Meta-analysis
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Abstract: Management of immune-mediated inflammatory diseases often requires lifelong immunosuppression. Increasing numbers of older patients have inflammatory diseases and are particularly …		 Nienke Z Borren; Ashwin N Ananthakrishnan;
2018 1 Nonalcoholic Steatohepatitis Is The Fastest Growing Cause Of Hepatocellular Carcinoma In Liver Transplant Candidates
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Abstract: Although hepatitis B and C have been the main drivers of hepatocellular carcinoma (HCC), nonalcoholic steatohepatitis (NASH) has recently become an important cause of HCC. The aim …		 ZOBAIR YOUNOSSI et. al.
2018 2 Safety Of Tofacitinib For Treatment Of Ulcerative Colitis, Based On 4.4 Years Of Data From Global Clinical Trials
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Abstract: Tofacitinib is an oral, small-molecule inhibitor of JAK approved in several countries for the treatment of ulcerative colitis (UC). We report integrated safety analyses of …		 WILLIAM J SANDBORN et. al.
2018 3 Magnetic Resonance Vs Transient Elastography Analysis of Patients With Nonalcoholic Fatty Liver Disease: A Systematic Review and Pooled Analysis of Individual Participants
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Abstract: Magnetic resonance elastography (MRE) and transient elastography (TE) are noninvasive techniques for detection of liver fibrosis. Single-center studies have compared the …		 CYNTHIA HSU et. al.
2018 4 Evidence To Support Monitoring Of Vedolizumab Trough Concentrations In Patients With Inflammatory Bowel Diseases
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Abstract: Trough concentrations of vedolizumab were found to correlate with clinical response in phase 3 studies of patients with ulcerative colitis (UC) or Crohn’s disease (CD). …		 ERWIN DREESEN et. al.
2018 5 AGA Institute Clinical Practice Update: Endoscopic Submucosal Dissection In The United States
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Abstract: Endoscopic submucosal dissection (ESD) is an established endoscopic resection method in Asian countries, which is increasingly practiced in Europe and by early adopters in the …		 Peter V Draganov; Andrew Y Wang; Mohamed O Othman; Norio Fukami;
2018 6 Tofacitinib Induction Therapy Reduces Symptoms Within 3 Days For Patients With Ulcerative Colitis
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Abstract: Tofacitinib is an oral, small molecule inhibitor of JAK for the treatment of ulcerative colitis (UC). We evaluated the onset of symptom improvement in post-hoc analyses of data …		 STEPHEN HANAUER et. al.
2018 7 Houston Consensus Conference On Testing For Helicobacter Pylori Infection In The United States
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Abstract: Despite guidelines for detection and treatment of Helicobacter pylori infection, recommendations to test patients before and after therapy are commonly not followed in the United …		 HASHEM B EL-SERAG et. al.
2018 8 Among Patients With Nonalcoholic Fatty Liver Disease, Modest Alcohol Use Is Associated With Less Improvement In Histologic Steatosis And Steatohepatitis
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Abstract: Cross-sectional studies of patients with nonalcoholic fatty liver disease (NAFLD) have reported a lower prevalence of severe disease among modest drinkers compared with …		 VEERAL AJMERA et. al.
2018 9 Prebiotics And Probiotics In Digestive Health
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Abstract: As the importance of the gut microbiota in health and disease is increasingly recognized interest in interventions that can modulate the microbiota and its interactions with its …		 Eamonn M M Quigley;
2018 10 Emerging Role Of The Gut Microbiome In Nonalcoholic Fatty Liver Disease: From Composition To Function
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Abstract: The gut microbiome, a diverse microbial community in the gastrointestinal tract, plays a pivotal role in the maintenance of health. The gut microbiome metabolizes dietary and …		 Suzanne R Sharpton; Veeral Ajmera; Rohit Loomba;
2017 1 Efficacy Of Glecaprevir/Pibrentasvir For 8 Or 12 Weeks In Patients With Hepatitis C Virus Genotype 2, 4, 5, Or 6 Infection Without Cirrhosis
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Abstract: Hepatitis C virus (HCV) has high genotypic diversity and global distribution. Agents that are effective against all major HCV genotypes, with shorter treatment duration, are …		 TARIK ASSELAH et. al.
2017 2 Gastric Cancer As Preventable Disease
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Abstract: Gastric cancer, 1 of the 5 most common causes of cancer death, is associated with a 5-year overall survival rate less than 30%. A minority of cancers occurs as part of syndromic …		 MASSIMO RUGGE et. al.
2017 3 Histologic Normalization Occurs In Ulcerative Colitis And Is Associated With Improved Clinical Outcomes
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Abstract: Mucosal healing, determined by histologic analysis, is a potential therapeutic target for patients with ulcerative colitis (UC). However, the histologic features of tissue …		 BRITT CHRISTENSEN et. al.
2017 4 Efficacy And Safety Of Peroral Endoscopic Myotomy For Treatment Of Achalasia After Failed Heller Myotomy
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Abstract: In patients with persistent symptoms after Heller myotomy (HM), treatment options include repeat HM, pneumatic dilation, or peroral endoscopic myotomy (POEM). We evaluated the …		 SAOWANEE NGAMRUENGPHONG et. al.
2017 5 Response To Pioglitazone In Patients With Nonalcoholic Steatohepatitis With Vs Without Type 2 Diabetes
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Abstract: Pioglitazone is effective for long-term treatment of patients with nonalcoholic steatohepatitis (NASH) with prediabetes or type 2 diabetes. However, it is not clear how the …		 FERNANDO BRIL et. al.
2017 6 Liver And Cardiovascular Damage In Patients With Lean Nonalcoholic Fatty Liver Disease, And Association With Visceral Obesity
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Abstract: Lean nonalcoholic fatty liver disease (NAFLD) is defined as NAFLD that develops in patients with a body mass index (BMI) less than 25 kg/m . We investigated the differences …		 ANNA LUDOVICA FRACANZANI et. al.
2017 7 Opioids In Gastroenterology: Treating Adverse Effects And Creating Therapeutic Benefits
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Abstract: The use of opioid medications on both an acute and chronic basis is ubiquitous in the United States. As opioid receptors densely populate the gastrointestinal tract, symptoms and …		 Michael Camilleri; Anthony Lembo; David A Katzka;
2017 8 Increases In IgE, Eosinophils, And Mast Cells Can Be Used In Diagnosis And To Predict Relapse Of IgG4-Related Disease
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Abstract: IgG subclass 4-related disease (IgG4-RD) is characterized by increased serum levels of IgG4 and infiltration of biliary, pancreatic, and other tissues by IgG4-positive plasma …		 EMMA L CULVER et. al.
2017 9 Use Of Biologic Therapy By Pregnant Women With Inflammatory Bowel Disease Does Not Affect Infant Response To Vaccines
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Abstract: In women with inflammatory bowel diseases (IBDs), exposure to immunomodulator or biologic therapy has not been associated with adverse events during pregnancy or outcomes of …		 DAWN B BEAULIEU et. al.
2017 10 Optimal Histologic Cutpoints For Treatment Response In Patients With Eosinophilic Esophagitis: Analysis Of Data From A Prospective Cohort Study
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Abstract: No prospective studies substantiate 15 eos/hpf as an appropriate endpoint for treatment of eosinophilic esophagitis (EoE). We aimed to determine a histologic cutpoint that …		 CRAIG C REED et. al.
2016 1 Biologic Therapies And Risk Of Infection And Malignancy In Patients With Inflammatory Bowel Disease: A Systematic Review And Network Meta-analysis
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Abstract: Safety issues are a major concern for patients considering treatments for inflammatory bowel disease (IBD). We performed a systematic review and meta-analysis to determine whether …		 STEFANOS BONOVAS et. al.
2016 2 Endoscopic Therapy With Lumen-apposing Metal Stents Is Safe And Effective For Patients With Pancreatic Walled-off Necrosis
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Abstract: Endoscopic ultrasound-guided transmural drainage and necrosectomy have become the standard treatment for patients with pancreatic walled-off necrosis (WON). Lumen-apposing metal …		 REEM Z SHARAIHA et. al.
2016 3 Nonobese Fatty Liver Disease
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Abstract: Nonalcoholic fatty liver disease (NAFLD) refers to a group of conditions characterized by hepatic steatosis in the absence of significant alcohol consumption. NAFLD is seen …		 Donghee Kim; W Ray Kim;
2016 4 Symptoms Of Depression And Anxiety Are Independently Associated With Clinical Recurrence Of Inflammatory Bowel Disease
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Abstract: We examined the relationship between symptoms of depression and anxiety and clinical recurrence of inflammatory bowel disease (IBD) in a large patient cohort. We considered the …		 Antonina Mikocka-Walus; Valerie Pittet; Jean-Benoît Rossel; Roland von Känel; R;
2016 5 Inflammatory Bowel Disease Affects The Outcome Of Fecal Microbiota Transplantation For Recurrent Clostridium Difficile Infection
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Abstract: A significant fraction of patients with recurrent Clostridium difficile infections (CDI) have inflammatory bowel disease (IBD). Fecal microbiota transplantation (FMT) can break …		 ALEXANDER KHORUTS et. al.
2016 6 Mucosal Healing Is Associated With Improved Long-term Outcomes Of Patients With Ulcerative Colitis: A Systematic Review And Meta-analysis
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Abstract: The paradigm for treatment for ulcerative colitis (UC) is shifting from resolving symptoms toward objective measures such as mucosal healing (MH). However, it is unclear whether …		 Shailja C Shah; Jean-Frederic Colombel; Bruce E Sands; Neeraj Narula;
2016 7 Risk Of Recurrent Pancreatitis And Progression To Chronic Pancreatitis After A First Episode Of Acute Pancreatitis
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Abstract: Patients with a first episode of acute pancreatitis can develop recurrent or chronic pancreatitis (CP). However, little is known about the incidence or risk factors for these …		 USAMA AHMED ALI et. al.
2016 8 Endoscopic Sleeve Gastroplasty Significantly Reduces Body Mass Index And Metabolic Complications In Obese Patients
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Abstract: Endoscopic sleeve gastroplasty (ESG) is an incisionless, minimally invasive bariatric procedure that reduces the length and width of the gastric cavity to facilitate weight loss. …		 REEM Z SHARAIHA et. al.
2016 9 Role Of The GALAD And BALAD-2 Serologic Models In Diagnosis Of Hepatocellular Carcinoma And Prediction Of Survival In Patients
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Abstract: GALAD and BALAD-2 are statistical models for estimating the likelihood of the presence of hepatocellular carcinoma (HCC) in individual patients with chronic liver disease and the …		 SARAH BERHANE et. al.
2016 10 Disparities In Absolute Denial Of Modern Hepatitis C Therapy by Type Of Insurance
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Abstract: The high costs of direct-acting antiviral (DAA) agents to treat chronic hepatitis C virus (HCV) infection have resulted in denials of treatment, but it is not clear whether …		 VINCENT LO RE et. al.
2015 1 Hepatocellular Carcinoma From Epidemiology To Prevention: Translating Knowledge Into Practice
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Abstract: The epidemiology of hepatocellular carcinoma (HCC) is characterized by dynamic temporal trends, several major established (i.e., HCV, HBV, alcohol) and emerging (i.e., diabetes, …		 Amit G Singal; Hashem B El-Serag;
2015 2 Hepatocellular Carcinoma In The Absence Of Cirrhosis In United States Veterans Is Associated With Nonalcoholic Fatty Liver Disease
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Abstract: Hepatocellular carcinoma (HCC) can develop in individuals without cirrhosis. We investigated risk factors for development of HCC in the absence of cirrhosis in a U.S. We …		 SAHIL MITTAL et. al.
2015 3 Curcumin In Combination With Mesalamine Induces Remission In Patients With Mild-to-Moderate Ulcerative Colitis In A Randomized Controlled Trial
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Abstract: The phytochemical compound curcumin was reported to be effective in maintaining remission in patients with ulcerative colitis (UC). We investigated curcumin’s efficacy in inducing …		 ALON LANG et. al.
2015 4 Defining Disease Severity In Inflammatory Bowel Diseases: Current And Future Directions
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Abstract: Although most treatment algorithms in inflammatory bowel disease (IBD) begin with classifying patients according to disease severity, no formal validated or consensus definitions …		 LAURENT PEYRIN-BIROULET et. al.
2015 5 Lifestyle Intervention In Gastroesophageal Reflux Disease
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Abstract: Gastroesophageal reflux disease (GERD) affects up to 30% of adults in Western populations and is increasing in prevalence. GERD is associated with lifestyle factors, particularly …		 Eivind Ness-Jensen; Kristian Hveem; Hashem El-Serag; Jesper Lagergren;
2015 6 Nonalcoholic Fatty Liver Disease Review: Diagnosis, Treatment, And Outcomes
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Abstract: Nonalcoholic fatty liver disease (NAFLD) is the most common cause of abnormal serum aminotransferase levels in both developed and developing countries. Patients with nonalcoholic …		 Aijaz Ahmed; Robert J Wong; Stephen A Harrison;
2015 7 Efficacy Of Proton Pump Inhibitor Drugs For Inducing Clinical And Histologic Remission In Patients With Symptomatic Esophageal Eosinophilia: A Systematic Review And Meta-Analysis
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Abstract: Proton pump inhibitor (PPI) therapy might lead to clinical and histologic remission in a significant proportion of patients with symptomatic esophageal eosinophilia (>15 …		 Alfredo J Lucendo; Ángel Arias; Javier Molina-Infante;
2015 8 Concentrations Of 6-thioguanine Nucleotide Correlate With Trough Levels Of Infliximab In Patients With Inflammatory Bowel Disease On Combination Therapy
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Abstract: In patients with inflammatory bowel diseases, the combination of infliximab and thiopurines (such as 6-thioguanine) is more effective treatment than monotherapy. We assessed the …		 ANDRES J YARUR et. al.
2015 9 Small Amounts Of Gluten In Subjects With Suspected Nonceliac Gluten Sensitivity: A Randomized, Double-Blind, Placebo-Controlled, Cross-Over Trial
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Abstract: There is debate over the existence of nonceliac gluten sensitivity (NCGS) intestinal and extraintestinal symptoms in response to ingestion of gluten-containing foods by people …		 ANTONIO DI SABATINO et. al.
2015 10 Pharmacokinetic Features And Presence Of Antidrug Antibodies Associate With Response To Infliximab Induction Therapy In Patients With Moderate To Severe Ulcerative Colitis
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Abstract: The pharmacokinetics of infliximab during induction treatment for ulcerative colitis (UC) have not been studied. We investigated serum concentrations of infliximab and the early …		 JOHANNAN F BRANDSE et. al.
2014 1 Fibrosis Progression In Nonalcoholic Fatty Liver Vs Nonalcoholic Steatohepatitis: A Systematic Review And Meta-analysis Of Paired-biopsy Studies
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Abstract: Little is known about differences in rates of fibrosis progression between patients with nonalcoholic fatty liver (NAFL) vs nonalcoholic steatohepatitis (NASH). We conducted a …		 SIDDHARTH SINGH et. al.
2014 2 Diagnostic Performance Of Magnetic Resonance Elastography In Staging Liver Fibrosis: A Systematic Review And Meta-analysis Of Individual Participant Data
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Abstract: Magnetic resonance elastography (MRE) is a noninvasive tool for staging liver fibrosis. We conducted a meta-analysis of individual participant data collected from published …		 SIDDHARTH SINGH et. al.
2014 3 Risk Of Lymphoma In Patients With Inflammatory Bowel Disease Treated With Azathioprine And 6-mercaptopurine: A Meta-analysis
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Abstract: Thiopurine therapy for inflammatory bowel disease (IBD) has been associated with increased risk for lymphoma. We estimated the relative risk of lymphoma in patients with IBD …		 DAVID S KOTLYAR et. al.
2014 4 Levels Of Drug And Antidrug Antibodies Are Associated With Outcome Of Interventions After Loss Of Response To Infliximab Or Adalimumab
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Abstract: There is controversy about whether levels of anti-tumor necrosis factor (TNF) and antidrug antibodies (ADAs) are accurate determinants of loss of response to therapy. We analyzed …		 HENIT YANAI et. al.
2014 5 A Phase 2 Study Of Tofacitinib, An Oral Janus Kinase Inhibitor, In Patients With Crohn’s Disease
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Abstract: Tofacitinib, an orally administered Janus kinase inhibitor, blocks signaling through γ-chain-containing cytokines (interleukins 2, 4, 7, 9, 15, and 21). We performed a phase 2 …		 WILLIAM J SANDBORN et. al.
2014 6 An Accelerated Infliximab Induction Regimen Reduces The Need For Early Colectomy In Patients With Acute Severe Ulcerative Colitis
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Abstract: Administration of infliximab to patients with acute severe ulcerative colitis (ASUC) (rescue therapy) can reduce the rate of early colectomy (within 12 months), but long-term …		 DAVID J GIBSON et. al.
2014 7 Resveratrol Does Not Benefit Patients With Nonalcoholic Fatty Liver Disease
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Abstract: Nonalcoholic fatty liver disease (NAFLD), characterized by accumulation of hepatic triglycerides (steatosis), is associated with abdominal obesity, insulin resistance, and …		 VERONIQUE S CHACHAY et. al.
2014 8 Safety And Efficacy Of Endoscopic Ultrasound-guided Drainage Of Pancreatic Fluid Collections With Lumen-apposing Covered Self-expanding Metal Stents
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Abstract: Plastic stents, placed via endoscopy to drain pancreatic fluid collections (PFCs), require repeat access. Covered metal stents are larger in diameter and can be inserted in a …		 RAJ J SHAH et. al.
2014 9 Temporal Trends Of Nonalcoholic Fatty Liver Disease-related Hepatocellular Carcinoma In The Veteran Affairs Population
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Abstract: Nonalcoholic fatty liver disease (NAFLD) is a risk factor for hepatocellular carcinoma (HCC). However, no systemic studies from the United States have examined temporal trends, …		 SAHIL MITTAL et. al.
2014 10 Patient-reported Outcomes As Primary End Points In Clinical Trials Of Inflammatory Bowel Disease
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Abstract: The Food and Drug Administration (FDA) is moving from the Crohn’s Disease Activity Index to patient-reported outcomes (PROs) and objective measures of disease, such as findings …		 Nicolas Williet; William J Sandborn; Laurent Peyrin-Biroulet;
2013 1 Fecal Microbiome And Volatile Organic Compound Metabolome In Obese Humans With Nonalcoholic Fatty Liver Disease
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Abstract: The histopathology of nonalcoholic fatty liver disease (NAFLD) is similar to that of alcoholic liver disease. Colonic bacteria are a source of many metabolic products, including …		 MAITREYI RAMAN et. al.
2013 2 Prevalence Of Eosinophilic Esophagitis In The United States
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Abstract: Eosinophilic esophagitis (EoE) has become a major cause of upper gastrointestinal morbidity in children and adults. However, there are few data on the nationwide prevalence of …		 Evan S Dellon; Elizabeth T Jensen; Christopher F Martin; Nicholas J Shaheen; Michael D Kappelman;
2013 3 Rational Helicobacter Pylori Therapy: Evidence-based Medicine Rather Than Medicine-based Evidence
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Abstract: Data are available such that choice of Helicobacter pylori therapy for an individual patient can be reliably predicted. Here, treatment success is defined as a cure rate of 90% or …		 David Y Graham; Yi-Chia Lee; Ming-Shiang Wu;
2013 4 Long-term Risk Of Acute Diverticulitis Among Patients With Incidental Diverticulosis Found During Colonoscopy
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Abstract: Colonic diverticulosis is the most common finding during routine colonoscopy, and patients often question the significance of these lesions. Guidelines state that these patients …		 KAMYAR SHAHEDI et. al.
2013 5 Association Between Pharmacokinetics Of Adalimumab And Mucosal Healing In Patients With Inflammatory Bowel Diseases
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Abstract: Little is known about the association between pharmacokinetic features of adalimumab and mucosal healing in patients with inflammatory bowel disease (IBD). We conducted a …		 XAVIER ROBLIN et. al.
2013 6 A Phase 2 Study Of Allogeneic Mesenchymal Stromal Cells For Luminal Crohn’s Disease Refractory To Biologic Therapy
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Abstract: Transplantation of peripheral blood stem cells has been successful therapy for small numbers of patients with Crohn’s disease (CD), but requires prior myeloconditioning. …		 GEOFFREY M FORBES et. al.
2013 7 Central Adiposity Is Associated With Increased Risk Of Esophageal Inflammation, Metaplasia, And Adenocarcinoma: A Systematic Review And Meta-analysis
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Abstract: Central adiposity has been implicated as a risk factor for Barrett’s esophagus (BE) and esophageal adenocarcinoma (EAC), possibly promoting the progression from inflammation to …		 SIDDHARTH SINGH et. al.
2013 8 Treat To Target: A Proposed New Paradigm For The Management Of Crohn’s Disease
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Abstract: The traditional management of Crohn’s disease, which is based on progressive, step-wise treatment intensification with re-evaluation of response according to symptoms, does not …		 GUILLAUME BOUGUEN et. al.
2013 9 Efficacy And Durability Of Radiofrequency Ablation For Barrett’s Esophagus: Systematic Review And Meta-analysis
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Abstract: In patients with Barrett’s esophagus (BE), radiofrequency ablation (RFA) safely and effectively eradicates dysplasia and intestinal metaplasia. We aimed to determine the efficacy …		 Eric S Orman; Nan Li; Nicholas J Shaheen;
2013 10 Liver Stiffness Is Associated with Risk of Decompensation, Liver Cancer, and Death in Patients with Chronic Liver Diseases: A Systematic Review and Meta-analysis
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Abstract: Liver stiffness measurement (LSM), using elastography, can independently predict outcomes of patients with chronic liver diseases (CLDs). However, there is much variation in …		 SIDDHARTH SINGH et. al.
2012 1 Global Prevalence Of And Risk Factors For Irritable Bowel Syndrome: A Meta-analysis
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Abstract: Many cross-sectional surveys have reported the prevalence of irritable bowel syndrome (IBS), but there have been no recent systematic review of data from all studies to determine …		 Rebecca M Lovell; Alexander C Ford;
2012 2 Risk Of Colorectal Cancer In Patients With Ulcerative Colitis: A Meta-analysis Of Population-based Cohort Studies
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Abstract: Patients with ulcerative colitis (UC) have an increased risk of developing colorectal cancer (CRC). Studies examining the magnitude of this association have yielded conflicting …		 Tine Jess; Christine Rungoe; Laurent Peyrin-Biroulet;
2012 3 Association Between Nonalcoholic Fatty Liver Disease And Risk For Hepatocellular Cancer, Based On Systematic Review
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Abstract: Nonalcoholic fatty liver disease (NAFLD) has been implicated as a cause of hepatocellular carcinoma (HCC). We performed a systematic review of epidemiology studies to confirm the …		 Donna L White; Fasiha Kanwal; Hashem B El-Serag;
2012 4 Placental Transfer Of Anti-tumor Necrosis Factor Agents In Pregnant Patients With Inflammatory Bowel Disease
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Abstract: Some women with inflammatory bowel disease require therapy with tumor necrosis factor (TNF) antagonists during pregnancy. It is not clear whether these drugs are transferred to …		 UMA MAHADEVAN et. al.
2012 5 Addition Of An Immunomodulator To Infliximab Therapy Eliminates Antidrug Antibodies In Serum And Restores Clinical Response Of Patients With Inflammatory Bowel Disease
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Abstract: There are few therapeutic options for patients with inflammatory bowel disease who lose response to infliximab because they produced antibodies against the drug. We performed a …		 SHOMRON BEN-HORIN et. al.
2012 6 Efficacy And Safety Of Anticoagulation On Patients With Cirrhosis And Portal Vein Thrombosis
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Abstract: Portal vein thrombosis (PVT) is a frequent event in patients with cirrhosis; it can be treated with anticoagulants, but there are limited data regarding safety and efficacy of …		 MARÍA GABRIELA DELGADO et. al.
2012 7 Swallowed Fluticasone Improves Histologic But Not Symptomatic Response Of Adults With Eosinophilic Esophagitis
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Abstract: We evaluated the effect of aerosolized fluticasone therapy on symptomatic dysphagia and histologic eosinophilia in adults with eosinophilic esophagitis (EoE). We performed a …		 JEFFREY A ALEXANDER et. al.
2012 8 Independent Association Between Nonalcoholic Fatty Liver Disease And Cardiovascular Disease In The US Population
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Abstract: Nonalcoholic fatty liver disease (NAFLD) and cardiovascular diseases (CVDs) have common metabolic risk factors. Despite reports from clinical studies, the association between …		 Maria Stepanova; Zobair M Younossi;
2012 9 Classification, Diagnosis, and Management of Cholangiocarcinoma
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Abstract: Cholangiocarcinomas (CCAs) are tumors that develop along the biliary tract. Depending on their site of origin, they have different features and require specific treatments. …		 Nataliya Razumilava; Gregory J Gores;
2012 10 The Prevalence And Diagnostic Utility Of Endoscopic Features Of Eosinophilic Esophagitis: A Meta-analysis
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Abstract: Endoscopic findings such as esophageal rings, strictures, narrow-caliber esophagus, linear furrows, white plaques, and pallor or decreased vasculature might indicate the presence …		 Hannah P Kim; R Brooks Vance; Nicholas J Shaheen; Evan S Dellon;
2011 1 Treating Clostridium Difficile Infection With Fecal Microbiota Transplantation
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Abstract: Clostridium difficile infection is increasing in incidence, severity, and mortality. Treatment options are limited and appear to be losing efficacy. Recurrent disease is …		 JOHAN S BAKKEN et. al.
2011 2 Changes In The Prevalence Of The Most Common Causes Of Chronic Liver Diseases In The United States From 1988 To 2008
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Abstract: Chronic liver diseases (CLDs) are major causes of morbidity and mortality worldwide. We assessed changes in the prevalence of different types of CLD in the United States. National …		 ZOBAIR M YOUNOSSI et. al.
2011 3 Muscle Wasting Is Associated With Mortality In Patients With Cirrhosis
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Abstract: Sarcopenia, defined as a low level of muscle mass, occurs in patients with cirrhosis. We assessed its incidence among cirrhotic patients undergoing evaluation for liver …		 ALDO J MONTANO-LOZA et. al.
2011 4 A Sustained Virologic Response Reduces Risk Of All-cause Mortality In Patients With Hepatitis C
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Abstract: The effectiveness of hepatitis C virus (HCV) treatment with pegylated interferon and ribavirin usually is evaluated by the surrogate end point of sustained virologic response …		 LISA I BACKUS et. al.
2011 5 Lactated Ringer’s Solution Reduces Systemic Inflammation Compared With Saline In Patients With Acute Pancreatitis
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Abstract: Aggressive fluid resuscitation is recommended for initial management of acute pancreatitis. We performed a randomized controlled trial to evaluate the impact of a goal-directed …		 BECHIEN U WU et. al.
2011 6 Long-term Budesonide Maintenance Treatment Is Partially Effective For Patients With Eosinophilic Esophagitis
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Abstract: Topical corticosteroids are effective in inducing clinical and histologic remission in patients with eosinophilic esophagitis (EoE). However, the best long-term management …		 ALEX STRAUMANN et. al.
2011 7 Characteristics Of Patients With Nonalcoholic Steatohepatitis Who Develop Hepatocellular Carcinoma
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Abstract: Nonalcoholic steatohepatitis (NASH) can progress to hepatocellular carcinoma (HCC). We aimed to characterize the clinical features of NASH patients with HCC. In a cross-sectional …		 KOHICHIROH YASUI et. al.
2011 8 Immune Dysfunction And Infections In Patients With Cirrhosis
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Abstract: Patients with cirrhosis are immunocompromised and susceptible to infections. Although detection and treatment of spontaneous bacterial peritonitis (SBP) have improved, overall …		 Alexander R Bonnel; Chalermrat Bunchorntavakul; K Rajender Reddy;
2011 9 Prevalence And Mechanisms Of Malnutrition In Patients With Advanced Liver Disease, And Nutrition Management Strategies
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Abstract: Malnutrition is prevalent among cirrhotic patients and is an important prognostic factor. Etiologic factors include hypermetabolism, malabsorption, altered nutrient metabolism, …		 Kally Cheung; Samuel S Lee; Maitreyi Raman;
2011 10 Induction And Maintenance Therapy With Infliximab For Children With Moderate To Severe Ulcerative Colitis
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Abstract: We evaluated the efficacy and safety of infliximab for inducing and maintaining benefit in children with moderately to severely active ulcerative colitis (UC). Patients (6-17 …		 JEFFREY HYAMS et. al.
2010 1 A Systematic Review Of Factors That Contribute To Hepatosplenic T-cell Lymphoma In Patients With Inflammatory Bowel Disease
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Abstract: Hepatosplenic T-cell lymphoma (HSTCL) is a rare and usually fatal lymphoma that primarily affects men younger than 35 years old. Treatment of patients with inflammatory bowel …		 DAVID S KOTLYAR et. al.
2010 2 A Sustained Viral Response Is Associated with Reduced Liver-related Morbidity and Mortality in Patients with Hepatitis C Virus
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Abstract: BACKGROUND & AIMS The incidences of decompensated cirrhosis (defined by ascites, hepatic encephalopathy, or bleeding esophageal varices), hepatocellular carcinoma (HCC), and …		 Amit G Singal; Michael L Volk; Donald Jensen; Adrian M Di Bisceglie; Philip S Schoenfeld;
2010 3 Risk of Esophageal Adenocarcinoma and Mortality in Patients with Barrett’s Esophagus: A Systematic Review and Meta-analysis
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Abstract: BACKGROUND & AIMS As the risk of esophageal adenocarcinoma (EAC) and mortality in patients with Barrett’s esophagus (BE) are important determinants of the potential yield and …		 Marjolein Sikkema; Pieter J F de Jonge; Ewout W Steyerberg; Ernst J Kuipers;
2010 4 Efficacy of Radiofrequency Ablation Combined with Endoscopic Resection for Barrett’s Esophagus with Early Neoplasia
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Abstract: BACKGROUND & AIMS Radiofrequency ablation (RFA) is safe and effective for eradicating intestinal metaplasia and neoplasia in patients with Barrett’s esophagus. We sought to assess …		 ROOS E POUW et. al.
2010 5 High Prevalence Of Pancreatic Cysts Detected By Screening Magnetic Resonance Imaging Examinations
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Abstract: The prevalence of pancreatic cysts is not known, but asymptomatic pancreatic cysts are diagnosed with increasing frequency. We investigated the prevalence of pancreatic cysts in …		 KOEN DE JONG et. al.
2010 6 Complication Rate Of Percutaneous Liver Biopsies Among Persons With Advanced Chronic Liver Disease In The HALT-C Trial
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Abstract: Although percutaneous liver biopsy is a standard diagnostic procedure, it has drawbacks, including risk of serious complications. It is not known whether persons with advanced …		 LEONARD B SEEFF et. al.
2010 7 Advanced Age Is An Independent Risk Factor For Severe Infections And Mortality In Patients Given Anti-tumor Necrosis Factor Therapy For Inflammatory Bowel Disease
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Abstract: Few data are available on effects of biologic therapies in patients more than 65 years old with inflammatory bowel disease (IBD). We evaluated the risk and benefits of therapy …		 MARIO COTTONE et. al.
2010 8 Correlation Between The Crohn’s Disease Activity And Harvey-Bradshaw Indices In Assessing Crohn’s Disease Severity
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Abstract: Clinical trials of Crohn’s disease generally use the Crohn’s Disease Activity Index to assess disease activity; these calculations are complex, time-consuming, and impracticable. …		 Severine Vermeire; Stefan Schreiber; William J Sandborn; Cécile Dubois; Paul Rutgeerts;
2010 9 Prevalence And Variable Detection Of Proximal Colon Serrated Polyps During Screening Colonoscopy
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Abstract: Colonoscopy may have a greater protective effect for distal colorectal cancer (CRC) than proximal CRC. Serrated polyps are frequently located in the proximal colon, can be missed …		 Charles J Kahi; David G Hewett; Dustin Lee Norton; George J Eckert; Douglas K Rex;
2010 10 Increased Incidence Of Small Intestinal Bacterial Overgrowth During Proton Pump Inhibitor Therapy
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Abstract: Proton pump inhibitors (PPIs) can cause diarrhea, enteric infections, and alter the gastrointestinal bacterial population by suppressing the gastric acid barrier. Among patients …		 Lucio Lombardo; Monica Foti; Olga Ruggia; Andrea Chiecchio;