Most Influential GASTROENTEROLOGY Papers

February 11, 2021May 23, 2021 admin

Gastroenterology is the most prominent journal in the field of gastrointestinal disease. As the official journal of the AGA Institute, Gastroenterology delivers up-to-date and authoritative coverage of both basic and clinical gastroenterology. Regular features include articles by leading authorities and reports on the latest treatments for diseases. Original research is organized by clinical and basic-translational content, as well as by alimentary tract, liver, pancreas, and biliary content. Paper Digest Team analyze all papers published on GASTROENTEROLOGY in the past years, and presents the 10 most influential papers for each year (based on when the paper became available online). This ranking list is automatically constructed based upon citations from both research papers and granted patents, and will be frequently updated to reflect the most recent changes. To find the most influential papers from other conferences/journals, visit Best Paper Digest page. Note: the most influential papers may or may not include the papers that won the best paper awards. (Last updated on: 2021-05-23)

If you do not want to miss any interesting academic paper, you are welcome to sign up our free daily paper digest service to get updates on new papers published in your area every day. To search for papers with highlights, related papers, patents, grants, experts and organizations, please visit our search console. You are also welcome to follow us on Twitter and Linkedin to get updated with new conference digests.

Paper Digest Team
team@paperdigest.org

TABLE 1: Most Influential GASTROENTEROLOGY Papers

Year	Rank	Paper	Author(s)
2020	1	Evidence For Gastrointestinal Infection Of SARS-CoV-2 IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details	FEI XIAO et. al.
2020	2	Gastrointestinal Manifestations of SARS-CoV-2 Infection and Virus Load in Fecal Samples From A Hong Kong Cohort: Systematic Review and Meta-analysis IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), which has been characterized by fever, respiratory, and …	KA SHING CHEUNG et. al.
2020	3	MAFLD: A Consensus-Driven Proposed Nomenclature for Metabolic Associated Fatty Liver Disease IF:5 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Fatty liver associated with metabolic dysfunction is common, affects a quarter of the population, and has no approved drug therapy. Although pharmacotherapies are in development, …	Mohammed Eslam; Arun J Sanyal; Jacob George; J;
2020	4	Corticosteroids, But Not TNF Antagonists, Are Associated With Adverse COVID-19 Outcomes in Patients With Inflammatory Bowel Diseases: Results From An International Registry IF:4 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The impact of Coronavirus disease 2019 (COVID-19) on patients with inflammatory bowel disease (IBD) is unknown. We sought to characterize the clinical course of COVID-19 among …	ERICA J BRENNER et. al.
2020	5	Alterations in Gut Microbiota of Patients With COVID-19 During Time of Hospitalization IF:4 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Although severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infects gastrointestinal tissues, little is known about the roles of gut commensal microbes in susceptibility …	TAO ZUO et. al.
2020	6	Pancreatic Injury Patterns in Patients With Coronavirus Disease 19 Pneumonia IF:4 Related Papers Related Patents Related Grants Related Orgs Related Experts Details	FAN WANG et. al.
2020	7	AGA Institute Rapid Review of The Gastrointestinal and Liver Manifestations of COVID-19, Meta-Analysis of International Data, and Recommendations for The Consultative Management of Patients with COVID-19 IF:4 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Multiple gastrointestinal (GI) symptoms, including diarrhea, nausea/vomiting, and abdominal pain, as well as liver enzyme abnormalities, have been variably reported in patients …	SHAHNAZ SULTAN et. al.
2020	8	AGA Rapid Recommendations for Gastrointestinal Procedures During The COVID-19 Pandemic IF:4 Related Papers Related Patents Related Grants Related Orgs Related Experts Details	SHAHNAZ SULTAN et. al.
2020	9	AGA Clinical Practice Update on Management of Inflammatory Bowel Disease During The COVID-19 Pandemic: Expert Commentary IF:3 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The purpose of this American Gastroenterological Association (AGA) Institute Clinical Practice Update was to rapidly review the emerging evidence and provide timely expert …	David T Rubin; Joseph D Feuerstein; Andrew Y Wang; Russell D Cohen;
2020	10	High Prevalence of Concurrent Gastrointestinal Manifestations in Patients With Severe Acute Respiratory Syndrome Coronavirus 2: Early Experience From California IF:3 Related Papers Related Patents Related Grants Related Orgs Related Experts Details	GEORGE CHOLANKERIL et. al.
2019	1	Noninvasive Assessment Of Liver Disease In Patients With Nonalcoholic Fatty Liver Disease IF:4 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Nonalcoholic fatty liver disease (NAFLD) is estimated to afflict approximately 1 billion individuals worldwide. In a subset of NAFLD patients, who have the progressive form of …	Laurent Castera; Mireen Friedrich-Rust; Rohit Loomba;
2019	2	Accuracy Of FibroScan Controlled Attenuation Parameter And Liver Stiffness Measurement In Assessing Steatosis And Fibrosis In Patients With Nonalcoholic Fatty Liver Disease IF:4 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: We estimated the accuracy of FibroScan vibration-controlled transient elastography controlled attenuation parameter (CAP) and liver stiffness measurement (LSMs) in assessing …	PETER J EDDOWES et. al.
2019	3	Hidden In Plain Sight IF:4 Related Papers Related Patents Related Grants Related Orgs Related Experts Details	Amrit K Kamboj; Vandana Nehra; Cadman L Leggett;
2019	4	Safety of Proton Pump Inhibitors Based on A Large, Multi-Year, Randomized Trial of Patients Receiving Rivaroxaban or Aspirin IF:4 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Proton pump inhibitors (PPIs) are effective at treating acid-related disorders. These drugs are well tolerated in the short term, but long-term treatment was associated with …	PAUL MOAYYEDI et. al.
2019	5	Early Detection Of Pancreatic Cancer: Opportunities And Challenges IF:3 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Most patients with pancreatic ductal adenocarcinoma (PDAC) present with symptomatic, surgically unresectable disease. Although the goal of early detection of PDAC is laudable and …	Aatur D Singhi; Eugene J Koay; Suresh T Chari; Anirban Maitra;
2019	6	Incidence And Etiology Of Drug-Induced Liver Injury In Mainland China IF:3 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: We performed a nationwide, retrospective study to determine the incidence and causes of drug-induced liver injury (DILI) in mainland China. We collected data on a total of 25,927 …	TAO SHEN et. al.
2019	7	Crohn’s Disease Exclusion Diet Plus Partial Enteral Nutrition Induces Sustained Remission In A Randomized Controlled Trial IF:3 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Exclusive enteral nutrition (EEN) is recommended for children with mild to moderate Crohn’s disease (CD), but implementation is challenging. We compared EEN with the CD exclusion …	ARIE LEVINE et. al.
2019	8	Gut Microbiota In Patients With Irritable Bowel Syndrome-A Systematic Review IF:3 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Irritable bowel syndrome (IBS) is common but difficult to treat. Altering the gut microbiota has been proposed as a strategy for treatment of IBS, but the association between the …	RAPAT PITTAYANON et. al.
2019	9	Fecal Microbiota Transplantation Is Superior To Fidaxomicin For Treatment Of Recurrent Clostridium Difficile Infection IF:3 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Fecal microbiota transplantation (FMT) is recommended for treatment of recurrent Clostridium difficile infection (rCDI). We performed a single-center randomized trial to compare …	CHRISTIAN LODBERG HVAS et. al.
2019	10	Inflammatory Bowel Disease In Pregnancy Clinical Care Pathway: A Report From The American Gastroenterological Association IBD Parenthood Project Working Group IF:3 Related Papers Related Patents Related Grants Related Orgs Related Experts Details	UMA MAHADEVAN et. al.
2018	1	Functional Bowel Disorders IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details	John W Wiley; Lin Chang;
2018	2	Burden And Cost Of Gastrointestinal, Liver, And Pancreatic Diseases In The United States: Update 2018 IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Estimates of disease burden can inform national health priorities for research, clinical care, and policy. We aimed to estimate health care use and spending among gastrointestinal …	ANNE F PEERY et. al.
2018	3	Deep Learning Localizes and Identifies Polyps in Real Time With 96% Accuracy in Screening Colonoscopy IF:5 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The benefit of colonoscopy for colorectal cancer prevention depends on the adenoma detection rate (ADR). The ADR should reflect the adenoma prevalence rate, which is estimated to …	GREGOR URBAN et. al.
2018	4	Updated International Consensus Diagnostic Criteria For Eosinophilic Esophagitis: Proceedings Of The AGREE Conference IF:5 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Over the last decade, clinical experiences and research studies raised concerns regarding use of proton pump inhibitors (PPIs) as part of the diagnostic strategy for eosinophilic …	EVAN S DELLON et. al.
2018	5	Prevalence Of Antibiotic Resistance In Helicobacter Pylori: A Systematic Review And Meta-analysis In World Health Organization Regions IF:5 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: In 2017, the World Health Organization (WHO) designated clarithromycin-resistant Helicobacter pylori a high priority for antibiotic research and development. However, there are no …	Alessia Savoldi; Elena Carrara; David Y Graham; Michela Conti; Evelina Tacconelli;
2018	6	Surveillance Imaging and Alpha Fetoprotein for Early Detection of Hepatocellular Carcinoma in Patients With Cirrhosis: A Meta-analysis IF:4 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Society guidelines differ in their recommendations for surveillance to detect early-stage hepatocellular carcinoma (HCC) in patients with cirrhosis. We compared the performance of …	KRISTINA TZARTZEVA et. al.
2018	7	Viral Hepatitis And Hepatocellular Carcinoma IF:4 Related Papers Related Patents Related Grants Related Orgs Related Experts Details	T Jake Liang; Norah Terrault;
2018	8	Fibrosis Severity As A Determinant Of Cause-Specific Mortality In Patients With Advanced Nonalcoholic Fatty Liver Disease: A Multi-National Cohort Study IF:4 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Little is known about the natural course of nonalcoholic fatty liver disease (NAFLD) with advanced fibrosis. We describe long-term outcomes and evaluate the effects of clinical …	EDUARDO VILAR-GOMEZ et. al.
2018	9	Risk Of Serious And Opportunistic Infections Associated With Treatment Of Inflammatory Bowel Diseases IF:4 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The risk of infection associated with tumor necrosis factor antagonists (anti-TNF) and thiopurines (combination therapy) is uncertain. We assessed the risk of serious and …	JULIEN KIRCHGESNER et. al.
2018	10	Risk Of Hepatocellular Cancer In Patients With Non-Alcoholic Fatty Liver Disease IF:4 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: There are limited data on the risk of hepatocellular cancer (HCC) in patients with non-alcoholic fatty liver disease (NAFLD). We aimed to estimate the risk of incident HCC among …	FASIHA KANWAL et. al.
2017	1	Global Prevalence Of Helicobacter Pylori Infection: Systematic Review And Meta-Analysis IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The epidemiology of Helicobacter pylori infection has changed with improvements in sanitation and methods of eradication. We performed a systematic review and meta-analysis to …	JAMES K Y HOOI et. al.
2017	2	Colorectal Cancer Screening: Recommendations For Physicians And Patients From The U.S. Multi-Society Task Force On Colorectal Cancer IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: This document updates the colorectal cancer (CRC) screening recommendations of the U.S. Multi-Society Task Force of Colorectal Cancer (MSTF), which represents the American College …	DOUGLAS K REX et. al.
2017	3	Risk Of Hepatocellular Cancer In HCV Patients Treated With Direct-Acting Antiviral Agents IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The risk of hepatocellular cancer (HCC) after sustained virological response (SVR) with direct-acting antivirals (DAA) is unclear. Our aim was to examine the risk and determinants …	FASIHA KANWAL et. al.
2017	4	The Risks And Benefits Of Long-term Use Of Proton Pump Inhibitors: Expert Review And Best Practice Advice From The American Gastroenterological Association IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The purpose of this review is to evaluate the risks associated with long-term use of proton pump inhibitors (PPIs), focusing on long-term use of PPIs for three common indications: …	Daniel E Freedberg; Lawrence S Kim; Yu-Xiao Yang;
2017	5	Changes In The Prevalence Of Hepatitis C Virus Infection, Nonalcoholic Steatohepatitis, And Alcoholic Liver Disease Among Patients With Cirrhosis Or Liver Failure On The Waitlist For Liver Transplantation IF:5 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Concurrent to development of more effective drugs for treatment of hepatitis C virus (HCV) infection, there has been an increase in the incidence of nonalcoholic fatty liver …	DAVID GOLDBERG et. al.
2017	6	Probiotic Bifidobacterium Longum NCC3001 Reduces Depression Scores And Alters Brain Activity: A Pilot Study In Patients With Irritable Bowel Syndrome IF:5 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Probiotics can reduce symptoms of irritable bowel syndrome (IBS), but little is known about their effects on psychiatric comorbidities. We performed a prospective study to …	MARIA INES PINTO-SANCHEZ et. al.
2017	7	Identification Of An Immune-specific Class Of Hepatocellular Carcinoma, Based On Molecular Features IF:5 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Agents that induce an immune response against tumors by altering T-cell regulation have increased survival times of patients with advanced-stage tumors, such as melanoma or lung …	DANIELA SIA et. al.
2017	8	American Gastroenterological Association Institute Guideline On Therapeutic Drug Monitoring In Inflammatory Bowel Disease IF:5 Related Papers Related Patents Related Grants Related Orgs Related Experts Details	JOSEPH D FEUERSTEIN et. al.
2017	9	Bile Acid Control Of Metabolism And Inflammation In Obesity, Type 2 Diabetes, Dyslipidemia, And Nonalcoholic Fatty Liver Disease IF:5 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Bile acids are signaling molecules that coordinately regulate metabolism and inflammation via the nuclear farnesoid X receptor (FXR) and the Takeda G protein-coupled receptor 5 …	Oscar Chávez-Talavera; Anne Tailleux; Philippe Lefebvre; Bart Staels;
2017	10	Epidemiology Of Esophageal Squamous Cell Carcinoma IF:5 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Esophageal squamous cell carcinoma (ESCC) accounts for about 90% of the 456,000 incident esophageal cancers each year. Regions of high incidence include Eastern to Central Asia, …	Christian C Abnet; Melina Arnold; Wen-Qiang Wei;
2016	1	Evidence-Based Diagnosis, Staging, And Treatment Of Patients With Hepatocellular Carcinoma IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Evidence-based management of patients with hepatocellular carcinoma (HCC) is key to their optimal care. For individuals at risk for HCC, surveillance usually involves …	Jordi Bruix; Maria Reig; Morris Sherman;
2016	2	Functional Gastrointestinal Disorders: History, Pathophysiology, Clinical Features And Rome IV IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Functional gastrointestinal disorders (FGIDs), the most common diagnoses in gastroenterology are recognized by morphological and physiological abnormalities that often occur in …	Douglas A Drossman;
2016	3	Childhood Functional Gastrointestinal Disorders: Neonate/Toddler IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: In 2006, a consensus concerning functional gastrointestinal intestinal disorders (FGIDs) in infants and toddlers was described. At that time little evidence regarding …	MARC A BENNINGA et. al.
2016	4	Functional Esophageal Disorders IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Functional esophageal disorders consist of a disease category that present with esophageal symptoms (heartburn, chest pain, dysphagia, globus) not explained by mechanical …	QASIM AZIZ et. al.
2016	5	Functional Anorectal Disorders IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: This report defines criteria and reviews the epidemiology, pathophysiology, and management of common anorectal disorders: fecal incontinence (FI), functional anorectal pain and …	SATISH SC RAO et. al.
2016	6	Rome IV-Functional GI Disorders: Disorders Of Gut-Brain Interaction IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details	Douglas A Drossman; William L Hasler;
2016	7	Hepatitis C Virus Resistance To Direct-Acting Antiviral Drugs In Interferon-Free Regimens IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Treatment of hepatitis C virus (HCV) infection has progressed considerably with the approval of interferon-free, direct-acting antiviral (DAA)-based combination therapies. …	Jean-Michel Pawlotsky;
2016	8	The Toronto Consensus For The Treatment Of Helicobacter Pylori Infection In Adults IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Helicobacter pylori infection is increasingly difficult to treat. The purpose of these consensus statements is to provide a review of the literature and specific, updated …	CARLO A FALLONE et. al.
2016	9	Gastroduodenal Disorders IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Symptoms that can be attributed to the gastroduodenal region represent one of the main subgroups among functional gastrointestinal disorders. A slightly modified classification …	VINCENZO STANGHELLINI et. al.
2016	10	Understanding And Preventing The Global Increase Of Inflammatory Bowel Disease IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The inflammatory bowel diseases (IBDs) are contemporary conditions of industrialized societies. The prevalence of IBD continues to increase steadily in Western countries, and …	Gilaad G Kaplan; Siew C Ng;
2015	1	Liver Fibrosis, But No Other Histologic Features, Is Associated With Long-term Outcomes Of Patients With Nonalcoholic Fatty Liver Disease IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Histologic analysis of liver biopsy specimens allows for grading and staging of nonalcoholic fatty liver disease (NAFLD). We performed a longitudinal study to investigate the …	PAUL ANGULO et. al.
2015	2	Fecal Microbiota Transplantation Induces Remission In Patients With Active Ulcerative Colitis In A Randomized Controlled Trial IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Ulcerative colitis (UC) is difficult to treat, and standard therapy does not always induce remission. Fecal microbiota transplantation (FMT) is an alternative approach that …	PAUL MOAYYEDI et. al.
2015	3	Weight Loss Through Lifestyle Modification Significantly Reduces Features Of Nonalcoholic Steatohepatitis IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: It is not clear how weight loss affects histologic features of liver in patients with nonalcoholic steatohepatitis (NASH). We examined the association between the magnitude of …	EDUARDO VILAR-GOMEZ et. al.
2015	4	Ledipasvir And Sofosbuvir Plus Ribavirin For Treatment Of HCV Infection In Patients With Advanced Liver Disease IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: There are no effective and safe treatments for chronic hepatitis C virus (HCV) infection of patients who have advanced liver disease. In this phase 2, open-label study, we …	MICHAEL CHARLTON et. al.
2015	5	Findings From A Randomized Controlled Trial Of Fecal Transplantation For Patients With Ulcerative Colitis IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Several case series have reported the effects of fecal microbiota transplantation (FMT) for ulcerative colitis (UC). We assessed the efficacy and safety of FMT for patients with …	NOORTJE G ROSSEN et. al.
2015	6	Trough Concentrations Of Infliximab Guide Dosing For Patients With Inflammatory Bowel Disease IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Infliximab, a tumor necrosis factor antagonist, is effective for treating patients with Crohn’s disease (CD) and ulcerative colitis (UC). We aimed to determine whether dosing …	NIELS VANDE CASTEELE et. al.
2015	7	Genetic Landscape And Biomarkers Of Hepatocellular Carcinoma IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Hepatocellular carcinoma (HCC) has emerged as a major cause of cancer-related death. Its mortality has increased in Western populations, with a minority of patients diagnosed at …	Jessica Zucman-Rossi; Augusto Villanueva; Jean-Charles Nault; Josep M Llovet;
2015	8	American Gastroenterological Association Institute Guideline On The Diagnosis And Management Of Asymptomatic Neoplastic Pancreatic Cysts IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details	SANTHI SWAROOP VEGE et. al.
2015	9	Burden Of Gastrointestinal, Liver, And Pancreatic Diseases In The United States IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Gastrointestinal (GI), liver, and pancreatic diseases are a source of substantial morbidity, mortality, and cost in the United States. Quantification and statistical analyses of …	ANNE F PEERY et. al.
2015	10	Bariatric Surgery Reduces Features Of Nonalcoholic Steatohepatitis In Morbidly Obese Patients IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The effects of bariatric surgery in patients with nonalcoholic fatty liver disease (NASH) are not well established. We performed a prospective study to determine the biological …	GUILLAUME LASSAILLY et. al.
2014	1	Nonalcoholic Steatohepatitis Is The Second Leading Etiology Of Liver Disease Among Adults Awaiting Liver Transplantation In The United States IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Nonalcoholic steatohepatitis (NASH) has been predicted to become the leading indication for liver transplantation (LT) in the United States. However, few studies have evaluated …	ROBERT J WONG et. al.
2014	2	The Microbiome In Inflammatory Bowel Disease: Current Status And The Future Ahead IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Studies of the roles of microbial communities in the development of inflammatory bowel disease (IBD) have reached an important milestone. A decade of genome-wide association …	Aleksandar D Kostic; Ramnik J Xavier; Dirk Gevers;
2014	3	Interactions Between The Intestinal Microbiome And Liver Diseases IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The human intestine harbors a diverse community of microbes that promote metabolism and digestion in their symbiotic relationship with the host. Disturbance of its homeostasis can …	Bernd Schnabl; David A Brenner;
2014	4	American Gastroenterological Association Institute Technical Review On Prevention And Treatment Of Hepatitis B Virus Reactivation During Immunosuppressive Drug Therapy IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details	Robert P Perrillo; Robert Gish; Yngve T Falck-Ytter;
2014	5	New Hepatitis C Therapies: The Toolbox, Strategies, And Challenges IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Therapy for hepatitis C is undergoing a revolution. Several new drugs against the hepatitis C virus (HCV) have reached the market and many others, including direct-acting …	Jean-Michel Pawlotsky;
2014	6	Effects Of Vedolizumab Induction Therapy For Patients With Crohn’s Disease In Whom Tumor Necrosis Factor Antagonist Treatment Failed IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: There is an increasing need for new treatments for patients with Crohn’s disease (CD) in whom previous therapy with tumor necrosis factor (TNF) antagonists has failed. We …	BRUCE E SANDS et. al.
2014	7	Roles For Chemokines In Liver Disease IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Sustained hepatic inflammation is an important factor in progression of chronic liver diseases, including hepatitis C or non-alcoholic steatohepatitis. Liver inflammation is …	Fabio Marra; Frank Tacke;
2014	8	Correlation Between Intraluminal Oxygen Gradient And Radial Partitioning Of Intestinal Microbiota IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The gut microbiota is a complex and densely populated community in a dynamic environment determined by host physiology. We investigated how intestinal oxygen levels affect the …	LINDSEY ALBENBERG et. al.
2014	9	Development Of Hong Kong Liver Cancer Staging System With Treatment Stratification For Patients With Hepatocellular Carcinoma IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: We aimed to develop a prognostic classification scheme with treatment guidance for Asian patients with hepatocellular carcinoma (HCC). We collected data from 3856 patients with …	THOMAS YAU et. al.
2014	10	Cell Death And Cell Death Responses In Liver Disease: Mechanisms And Clinical Relevance IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Hepatocellular death is present in almost all types of human liver disease and is used as a sensitive parameter for the detection of acute and chronic liver disease of viral, …	Tom Luedde; Neil Kaplowitz; Robert F Schwabe;
2013	1	Acute-on-chronic Liver Failure Is A Distinct Syndrome That Develops In Patients With Acute Decompensation Of Cirrhosis IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Patients with cirrhosis hospitalized for an acute decompensation (AD) and organ failure are at risk for imminent death and considered to have acute-on-chronic liver failure …	RICHARD MOREAU et. al.
2013	2	A Diet Low In FODMAPs Reduces Symptoms Of Irritable Bowel Syndrome IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: A diet low in fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAPs) often is used to manage functional gastrointestinal symptoms in patients with …	Emma P Halmos; Victoria A Power; Susan J Shepherd; Peter R Gibson; Jane G Muir;
2013	3	Consumption Of Fermented Milk Product With Probiotic Modulates Brain Activity IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Changes in gut microbiota have been reported to alter signaling mechanisms, emotional behavior, and visceral nociceptive reflexes in rodents. However, alteration of the intestinal …	KIRSTEN TILLISCH et. al.
2013	4	Pathogenesis, Diagnosis, And Management Of Cholangiocarcinoma IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Cholangiocarcinomas (CCAs) are hepatobiliary cancers with features of cholangiocyte differentiation; they can be classified anatomically as intrahepatic CCA (iCCA), perihilar CCA …	Sumera Rizvi; Gregory J Gores;
2013	5	Efficacy And Safety Of The Farnesoid X Receptor Agonist Obeticholic Acid In Patients With Type 2 Diabetes And Nonalcoholic Fatty Liver Disease IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Obeticholic acid (OCA; INT-747, 6α-ethyl-chenodeoxycholic acid) is a semisynthetic derivative of the primary human bile acid chenodeoxycholic acid, the natural agonist of the …	SUNDER MUDALIAR et. al.
2013	6	No Effects Of Gluten In Patients With Self-reported Non-celiac Gluten Sensitivity After Dietary Reduction Of Fermentable, Poorly Absorbed, Short-chain Carbohydrates IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Patients with non-celiac gluten sensitivity (NCGS) do not have celiac disease but their symptoms improve when they are placed on gluten-free diets. We investigated the specific …	JESSICA R BIESIEKIERSKI et. al.
2013	7	Subcutaneous Golimumab Induces Clinical Response And Remission In Patients With Moderate-to-severe Ulcerative Colitis IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Little is known about the efficacy of golimumab, a fully human monoclonal antibody to tumor necrosis factor (TNF) -α, for treatment of ulcerative colitis (UC). We evaluated …	WILLIAM J SANDBORN et. al.
2013	8	Combination Therapy With Infliximab And Azathioprine Is Superior To Monotherapy With Either Agent In Ulcerative Colitis IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The comparative efficacy and safety of infliximab and azathioprine therapy alone or in combination for ulcerative colitis (UC) have not been evaluated previously. This randomized, …	REMO PANACCIONE et. al.
2013	9	Incidence And Phenotype Of Inflammatory Bowel Disease Based On Results From The Asia-pacific Crohn’s And Colitis Epidemiology Study IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Inflammatory bowel diseases (IBD) are becoming more common in Asia, but epidemiologic data are lacking. The Asia-Pacific Crohn’s and Colitis Epidemiology Study aimed to determine …	SIEW C NG et. al.
2013	10	Subcutaneous Golimumab Maintains Clinical Response In Patients With Moderate-to-severe Ulcerative Colitis IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Subcutaneous golimumab, a fully human monoclonal antibody to tumor necrosis factor-α (TNFα), was evaluated as maintenance therapy in TNFα antagonist-naive adults with …	WILLIAM J SANDBORN et. al.
2012	1	Transfer Of Intestinal Microbiota From Lean Donors Increases Insulin Sensitivity In Individuals With Metabolic Syndrome IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Alterations in intestinal microbiota are associated with obesity and insulin resistance. We studied the effects of infusing intestinal microbiota from lean donors to male …	ANNE VRIEZE et. al.
2012	2	Burden Of Gastrointestinal Disease In The United States: 2012 Update IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Gastrointestinal (GI) diseases account for substantial morbidity, mortality, and cost. Statistical analyses of the most recent data are necessary to guide GI research, education, …	ANNE F PEERY et. al.
2012	3	Guidelines For Colonoscopy Surveillance After Screening And Polypectomy: A Consensus Update By The US Multi-Society Task Force On Colorectal Cancer IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details	DAVID A LIEBERMAN et. al.
2012	4	The Diagnosis And Management Of Non-alcoholic Fatty Liver Disease: Practice Guideline By The American Gastroenterological Association, American Association For The Study Of Liver Diseases, And American College Of Gastroenterology IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details	NAGA CHALASANI et. al.
2012	5	The Epidemiology Of Pancreatitis And Pancreatic Cancer IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Acute pancreatitis is one of the most frequent gastrointestinal causes of hospital admission in the United States. Chronic pancreatitis, although lower in incidence, significantly …	Dhiraj Yadav; Albert B Lowenfels;
2012	6	Role Of Obesity And Lipotoxicity In The Development Of Nonalcoholic Steatohepatitis: Pathophysiology And Clinical Implications IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: As obesity reaches epidemic proportions, nonalcoholic fatty liver disease (NAFLD) is becoming a frequent cause of patient referral to gastroenterologists. There is a close link …	Kenneth Cusi;
2012	7	Incomplete Polyp Resection During Colonoscopy-results Of The Complete Adenoma Resection (CARE) Study IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Although the adenoma detection rate is used as a measure of colonoscopy quality, there are limited data on the quality of endoscopic resection of detected adenomas. We determined …	HEIKO POHL et. al.
2012	8	Elimination Diet Effectively Treats Eosinophilic Esophagitis In Adults; Food Reintroduction Identifies Causative Factors IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Adults with eosinophilic esophagitis (EoE) typically present with dysphagia and food impaction. A 6-food elimination diet (SFED) is effective in children with EoE. We assessed the …	NIRMALA GONSALVES et. al.
2012	9	American Gastroenterological Association Technical Review On Constipation IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details	Adil E Bharucha; John H Pemberton; G Richard Locke;
2012	10	Enoxaparin Prevents Portal Vein Thrombosis And Liver Decompensation In Patients With Advanced Cirrhosis IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: We performed a randomized controlled trial to evaluate the safety and efficacy of enoxaparin, a low-molecular-weight heparin, in preventing portal vein thrombosis (PVT) in …	ERICA VILLA et. al.
2011	1	Increasing Incidence And Prevalence Of The Inflammatory Bowel Diseases With Time, Based On Systematic Review IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: We conducted a systematic review to determine changes in the worldwide incidence and prevalence of ulcerative colitis (UC) and Crohn’s disease (CD) in different regions and with …	NATALIE A MOLODECKY et. al.
2011	2	Long-term Expansion Of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, And Barrett’s Epithelium IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: We previously established long-term culture conditions under which single crypts or stem cells derived from mouse small intestine expand over long periods. The expanding crypts …	TOSHIRO SATO et. al.
2011	3	Epidemiology Of Viral Hepatitis And Hepatocellular Carcinoma IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Most cases of hepatocellular carcinoma (HCC) are associated with cirrhosis related to chronic hepatitis B virus (HBV) or hepatitis C virus (HCV) infection. Changes in the time …	Hashem B El-Serag;
2011	4	Alcoholic Liver Disease: Pathogenesis And New Therapeutic Targets IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Alcoholic liver disease (ALD) is a major cause of chronic liver disease worldwide and can lead to fibrosis and cirrhosis. The latest surveillance report published by the National …	Bin Gao; Ramon Bataller;
2011	5	The Intestinal Microbiota Affect Central Levels Of Brain-derived Neurotropic Factor And Behavior In Mice IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Alterations in the microbial composition of the gastrointestinal tract (dysbiosis) are believed to contribute to inflammatory and functional bowel disorders and psychiatric …	PREMYSL BERCIK et. al.
2011	6	Frequency And Outcomes Of Liver Transplantation For Nonalcoholic Steatohepatitis In The United States IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The relative frequency of nonalcoholic steatohepatitis (NASH) as an indication for liver transplantation and comparative outcomes following transplantation are poorly understood. …	MICHAEL R CHARLTON et. al.
2011	7	American Gastroenterological Association Medical Position Statement On The Management Of Barrett’s Esophagus IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details	STUART J SPECHLER et. al.
2011	8	American Gastroenterological Association Technical Review On The Management Of Barrett’s Esophagus IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details	STUART J SPECHLER et. al.
2011	9	Pancreatitis, Pancreatic, And Thyroid Cancer With Glucagon-like Peptide-1-based Therapies IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Glucagon-like peptide-1-based therapy is gaining widespread use for type 2 diabetes, although there are concerns about risks for pancreatitis and pancreatic and thyroid cancers. …	Michael Elashoff; Aleksey V Matveyenko; Belinda Gier; Robert Elashoff; Peter C Butler;
2011	10	Global And Deep Molecular Analysis Of Microbiota Signatures In Fecal Samples From Patients With Irritable Bowel Syndrome IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Irritable bowel syndrome (IBS) has been associated with disruptions to the intestinal microbiota, but studies have had limited power, coverage, and depth of analysis. We aimed to …	MIRJANA RAJILIĆ-STOJANOVIĆ et. al.
2010	1	Prevalence Of Nonalcoholic Fatty Liver Disease And Nonalcoholic Steatohepatitis Among A Largely Middle-aged Population Utilizing Ultrasound And Liver Biopsy: A Prospective Study IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Prevalence of nonalcoholic fatty liver disease (NAFLD) has not been well established. The purpose of this study was to prospectively define the prevalence of both NAFLD and …	CHRISTOPHER D WILLIAMS et. al.
2010	2	Epidemiology And Natural History Of Inflammatory Bowel Diseases IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: In the West, the incidence and prevalence of inflammatory bowel diseases has increased in the past 50 years, up to 8-14/100,000 and 120-200/100,000 persons, respectively, for …	Jacques Cosnes; Corinne Gower-Rousseau; Philippe Seksik; Antoine Cortot;
2010	3	Inflammation and Colon Cancer IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The connection between inflammation and tumorigenesis is well-established and in the last decade has received a great deal of supporting evidence from genetic, pharmacological, …	Janos Terzić; Sergei Grivennikov; Eliad Karin; Michael Karin;
2010	4	Genetic Variation In IL28B Is Associated With Chronic Hepatitis C And Treatment Failure: A Genome-wide Association Study IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Hepatitis C virus (HCV) induces chronic infection in 50% to 80% of infected persons; approximately 50% of these do not respond to therapy. We performed a genome-wide association …	ANDRI RAUCH et. al.
2010	5	Hereditary and Familial Colon Cancer IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Between 2% to 5% of all colon cancers arise in the setting of well-defined inherited syndromes, including Lynch syndrome, familial adenomatous polyposis, MUTYH-associated …	Kory W Jasperson; Thérèse M Tuohy; Deborah W Neklason; Randall W Burt;
2010	6	Proinflammatory Cytokines In The Pathogenesis Of Inflammatory Bowel Diseases IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The cytokine responses characterizing the inflammatory bowel diseases are the key pathophysiologic elements that govern the initiation, evolution, and, ultimately, the resolution …	Warren Strober; Ivan J Fuss;
2010	7	A Pyrosequencing Study In Twins Shows That Gastrointestinal Microbial Profiles Vary With Inflammatory Bowel Disease Phenotypes IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The composition of the gastrointestinal microbiota is thought to have an important role in the etiology of inflammatory bowel diseases (IBDs) such as Crohn’s disease (CD) and …	BEN P WILLING et. al.
2010	8	Intestinal Inflammation And Cancer IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Patients with ulcerative colitis and Crohn’s disease are at increased risk for developing colorectal cancer (CRC). Chronic inflammation is believed to promote carcinogenesis. The …	Thomas A Ullman; Steven H Itzkowitz;
2010	9	Radioembolization for Hepatocellular Carcinoma Using Yttrium-90 Microspheres: A Comprehensive Report of Long-term Outcomes IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: BACKGROUND & AIMS Hepatocellular carcinoma (HCC) has limited treatment options; long-term outcomes following intra-arterial radiation are unknown. We assessed clinical outcomes of …	RIAD SALEM et. al.
2010	10	Role of The Serrated Pathway in Colorectal Cancer Pathogenesis IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The serrated neoplastic pathway describes the progression of serrated polyps, including sessile serrated adenomas and traditional serrated adenomas, to colorectal cancer. The …	Barbara Leggett; Vicki Whitehall;