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Most Influential JAMA Papers

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JAMA: The Journal of the American Medical Association is a peer-reviewed medical journal published 48 times a year by the American Medical Association. It publishes original research, reviews, and editorials covering all aspects of biomedicine. Paper Digest Team analyze all papers published on JAMA in the past years, and presents the 10 most influential papers for each year (based on when the paper became available online). This ranking list is automatically constructed based upon citations from both research papers and granted patents, and will be frequently updated to reflect the most recent changes. To find the most influential papers from other conferences/journals, visit Best Paper Digest page. Note: the most influential papers may or may not include the papers that won the best paper awards. (Last updated on: 2021-05-23)

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TABLE 1: Most Influential JAMA Papers

Year Rank Paper Author(s)
2020 1 Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China
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Abstract: In December 2019, novel coronavirus (2019-nCoV)-infected pneumonia (NCIP) occurred in Wuhan, China. The number of cases has increased rapidly but information on the clinical …		 DAWEI WANG et. al.
2020 2 Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in The New York City Area
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Abstract: There is limited information describing the presenting characteristics and outcomes of US patients requiring hospitalization for coronavirus disease 2019 (COVID-19). To describe …		 SAFIYA RICHARDSON et. al.
2020 3 Detection of SARS-CoV-2 in Different Types of Clinical Specimens
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 WENLING WANG et. al.
2020 4 Presumed Asymptomatic Carrier Transmission of COVID-19
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 YAN BAI et. al.
2020 5 Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Admitted to ICUs of The Lombardy Region, Italy
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Abstract: In December 2019, a novel coronavirus (severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]) emerged in China and has spread globally, creating a pandemic. Information …		 GIACOMO GRASSELLI et. al.
2020 6 Case-Fatality Rate And Characteristics Of Patients Dying In Relation To COVID-19 In Italy
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 Graziano Onder; Giovanni Rezza; Silvio Brusaferro;
2020 7 Treatment of 5 Critically Ill Patients With COVID-19 With Convalescent Plasma
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Abstract: Coronavirus disease 2019 (COVID-19) is a pandemic with no specific therapeutic agents and substantial mortality. It is critical to find new treatments. To determine whether …		 CHENGUANG SHEN et. al.
2020 8 Pharmacologic Treatments for Coronavirus Disease 2019 (COVID-19): A Review
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Abstract: The pandemic of coronavirus disease 2019 (COVID-19) caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) presents an unprecedented challenge to …		 James M Sanders; Marguerite L Monogue; Tomasz Z Jodlowski; James B Cutrell;
2020 9 Epidemiologic Features and Clinical Course of Patients Infected With SARS-CoV-2 in Singapore
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Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan, China, in December 2019 and has spread globally with sustained human-to-human transmission outside …		 BARNABY EDWARD YOUNG et. al.
2020 10 Characteristics and Outcomes of 21 Critically Ill Patients With COVID-19 in Washington State
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 MATT ARENTZ et. al.
2019 1 Mediation Analysis
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 Hopin Lee; Robert D Herbert; James H McAuley;
2019 2 Breast Cancer Treatment: A Review
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Abstract: Breast cancer will be diagnosed in 12% of women in the United States over the course of their lifetimes and more than 250 000 new cases of breast cancer were diagnosed in the …		 Adrienne G Waks; Eric P Winer;
2019 3 Preventing Maternal Deaths
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 Bridget Kuehn;
2019 4 Ending The HIV Epidemic: A Plan For The United States
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 Anthony S Fauci; Robert R Redfield; George Sigounas; Michael D Weahkee; Brett P Giroir;
2019 5 Effect Of Catheter Ablation Vs Antiarrhythmic Drug Therapy On Mortality, Stroke, Bleeding, And Cardiac Arrest Among Patients With Atrial Fibrillation: The CABANA Randomized Clinical Trial
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Abstract: Catheter ablation is effective in restoring sinus rhythm in atrial fibrillation (AF), but its effects on long-term mortality and stroke risk are uncertain. To determine whether …		 DOUGLAS L PACKER et. al.
2019 6 Effect of Intensive Vs Standard Blood Pressure Control on Probable Dementia: A Randomized Clinical Trial
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Abstract: There are currently no proven treatments to reduce the risk of mild cognitive impairment and dementia. To evaluate the effect of intensive blood pressure control on risk of …		 JEFF D WILLIAMSON et. al.
2019 7 N95 Respirators Vs Medical Masks for Preventing Influenza Among Health Care Personnel: A Randomized Clinical Trial
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Abstract: Clinical studies have been inconclusive about the effectiveness of N95 respirators and medical masks in preventing health care personnel (HCP) from acquiring workplace viral …		 LEWIS J RADONOVICH et. al.
2019 8 Management Of Patients With Atrial Fibrillation
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 Andrew D Beaser; Adam S Cifu;
2019 9 Derivation, Validation, And Potential Treatment Implications Of Novel Clinical Phenotypes For Sepsis
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Abstract: Sepsis is a heterogeneous syndrome. Identification of distinct clinical phenotypes may allow more precise therapy and improve care. To derive sepsis phenotypes from clinical data, …		 CHRISTOPHER W SEYMOUR et. al.
2019 10 Effect of Vitamin C Infusion on Organ Failure and Biomarkers of Inflammation and Vascular Injury in Patients With Sepsis and Severe Acute Respiratory Failure: The CITRIS-ALI Randomized Clinical Trial
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Abstract: Experimental data suggest that intravenous vitamin C may attenuate inflammation and vascular injury associated with sepsis and acute respiratory distress syndrome (ARDS). To …		 ALPHA A FOWLER et. al.
2018 1 The Physical Activity Guidelines For Americans
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Abstract: Approximately 80% of US adults and adolescents are insufficiently active. Physical activity fosters normal growth and development and can make people feel, function, and sleep …		 KATRINA L PIERCY et. al.
2018 2 Trends In Obesity And Severe Obesity Prevalence In US Youth And Adults By Sex And Age, 2007-2008 To 2015-2016
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 Craig M Hales; Cheryl D Fryar; Margaret D Carroll; David S Freedman; Cynthia L Ogden;
2018 3 Preferred Reporting Items for A Systematic Review and Meta-analysis of Diagnostic Test Accuracy Studies: The PRISMA-DTA Statement
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Abstract: Systematic reviews of diagnostic test accuracy synthesize data from primary diagnostic studies that have evaluated the accuracy of 1 or more index tests against a reference …		 MATTHEW D F MCINNES et. al.
2018 4 Health Care Spending In The United States And Other High-Income Countries
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Abstract: Health care spending in the United States is a major concern and is higher than in other high-income countries, but there is little evidence that efforts to reform US health care …		 Irene Papanicolas; Liana R Woskie; Ashish K Jha;
2018 5 Screening For Prostate Cancer: US Preventive Services Task Force Recommendation Statement
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Abstract: In the United States, the lifetime risk of being diagnosed with prostate cancer is approximately 13%, and the lifetime risk of dying of prostate cancer is 2.5%. The median age of …		 DAVID C GROSSMAN et. al.
2018 6 The State Of US Health, 1990-2016: Burden Of Diseases, Injuries, And Risk Factors Among US States
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Abstract: Several studies have measured health outcomes in the United States, but none have provided a comprehensive assessment of patterns of health by state. To use the results of the …		 ALI H MOKDAD et. al.
2018 7 Effect Of Linagliptin Vs Placebo On Major Cardiovascular Events In Adults With Type 2 Diabetes And High Cardiovascular And Renal Risk: The CARMELINA Randomized Clinical Trial
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Abstract: Type 2 diabetes is associated with increased cardiovascular (CV) risk. Prior trials have demonstrated CV safety of 3 dipeptidyl peptidase 4 (DPP-4) inhibitors but have included …		 JULIO ROSENSTOCK et. al.
2018 8 Big Data And Machine Learning In Health Care
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 Andrew L Beam; Isaac S Kohane;
2018 9 Effect Of Laparoscopic Sleeve Gastrectomy Vs Laparoscopic Roux-en-Y Gastric Bypass On Weight Loss In Patients With Morbid Obesity: The SM-BOSS Randomized Clinical Trial
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Abstract: Sleeve gastrectomy is increasingly used in the treatment of morbid obesity, but its long-term outcome vs the standard Roux-en-Y gastric bypass procedure is unknown. To determine …		 RALPH PETERLI et. al.
2018 10 Effect Of Opioid Vs Nonopioid Medications On Pain-Related Function In Patients With Chronic Back Pain Or Hip Or Knee Osteoarthritis Pain: The SPACE Randomized Clinical Trial
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Abstract: Limited evidence is available regarding long-term outcomes of opioids compared with nonopioid medications for chronic pain. To compare opioid vs nonopioid medications over 12 …		 ERIN E KREBS et. al.
2017 1 Antithrombotic Therapy For Venous Thromboembolic Disease
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 Atul Jain; Adam S Cifu;
2017 2 Diagnostic Assessment of Deep Learning Algorithms for Detection of Lymph Node Metastases in Women With Breast Cancer
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Abstract: Application of deep learning algorithms to whole-slide pathology images can potentially improve diagnostic accuracy and efficiency. Assess the performance of automated deep …		 BABAK EHTESHAMI BEJNORDI et. al.
2017 3 Risks Of Breast, Ovarian, And Contralateral Breast Cancer For BRCA1 And BRCA2 Mutation Carriers
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Abstract: The clinical management of BRCA1 and BRCA2 mutation carriers requires accurate, prospective cancer risk estimates. To estimate age-specific risks of breast, ovarian, and …		 KAROLINE B KUCHENBAECKER et. al.
2017 4 Global Burden Of Hypertension And Systolic Blood Pressure Of At Least 110 To 115 Mm Hg, 1990-2015
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Abstract: Elevated systolic blood (SBP) pressure is a leading global health risk. Quantifying the levels of SBP is important to guide prevention policies and interventions. To estimate the …		 MOHAMMAD H FOROUZANFAR et. al.
2017 5 Prevalence And Ethnic Pattern Of Diabetes And Prediabetes In China In 2013
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Abstract: Previous studies have shown increasing prevalence of diabetes in China, which now has the world’s largest diabetes epidemic. To estimate the recent prevalence and to investigate …		 LIMIN WANG et. al.
2017 6 Overall Survival Results Of A Trial Assessing Patient-Reported Outcomes For Symptom Monitoring During Routine Cancer Treatment
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 ETHAN BASCH et. al.
2017 7 Trends In Thyroid Cancer Incidence And Mortality In The United States, 1974-2013
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Abstract: Thyroid cancer incidence has increased substantially in the United States over the last 4 decades, driven largely by increases in papillary thyroid cancer. It is unclear whether …		 Hyeyeun Lim; Susan S Devesa; Julie A Sosa; David Check; Cari M Kitahara;
2017 8 Development And Validation Of A Deep Learning System For Diabetic Retinopathy And Related Eye Diseases Using Retinal Images From Multiethnic Populations With Diabetes
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Abstract: A deep learning system (DLS) is a machine learning technology with potential for screening diabetic retinopathy and related eye diseases. To evaluate the performance of a DLS in …		 DANIEL SHU WEI TING et. al.
2017 9 Effect Of Tumor-Treating Fields Plus Maintenance Temozolomide Vs Maintenance Temozolomide Alone On Survival In Patients With Glioblastoma: A Randomized Clinical Trial
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Abstract: Tumor-treating fields (TTFields) is an antimitotic treatment modality that interferes with glioblastoma cell division and organelle assembly by delivering low-intensity …		 ROGER STUPP et. al.
2017 10 Incidence And Trends Of Sepsis In US Hospitals Using Clinical Vs Claims Data, 2009-2014
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Abstract: Estimates from claims-based analyses suggest that the incidence of sepsis is increasing and mortality rates from sepsis are decreasing. However, estimates from claims data may …		 CHANU RHEE et. al.
2016 1 The Third International Consensus Definitions For Sepsis And Septic Shock (Sepsis-3)
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Abstract: Definitions of sepsis and septic shock were last revised in 2001. Considerable advances have since been made into the pathobiology (changes in organ function, morphology, cell …		 MERVYN SINGER et. al.
2016 2 CDC Guideline For Prescribing Opioids For Chronic Pain–United States, 2016
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Abstract: Primary care clinicians find managing chronic pain challenging. Evidence of long-term efficacy of opioids for chronic pain is limited. Opioid use is associated with serious risks, …		 Deborah Dowell; Tamara M Haegerich; Roger Chou;
2016 3 Development And Validation Of A Deep Learning Algorithm For Detection Of Diabetic Retinopathy In Retinal Fundus Photographs
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Abstract: Deep learning is a family of computational methods that allow an algorithm to program itself by learning from a large set of examples that demonstrate the desired behavior, …		 VARUN GULSHAN et. al.
2016 4 Trends In Obesity Among Adults In The United States, 2005 To 2014
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Abstract: Between 1980 and 2000, the prevalence of obesity increased significantly among adult men and women in the United States; further significant increases were observed through …		 Katherine M Flegal; Deanna Kruszon-Moran; Margaret D Carroll; Cheryl D Fryar; Cynthia L Ogden;
2016 5 Epidemiology, Patterns Of Care, And Mortality For Patients With Acute Respiratory Distress Syndrome In Intensive Care Units In 50 Countries
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Abstract: Limited information exists about the epidemiology, recognition, management, and outcomes of patients with the acute respiratory distress syndrome (ARDS). To evaluate intensive …		 GIACOMO BELLANI et. al.
2016 6 Assessment Of Clinical Criteria For Sepsis: For The Third International Consensus Definitions For Sepsis And Septic Shock (Sepsis-3)
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Abstract: The Third International Consensus Definitions Task Force defined sepsis as life-threatening organ dysfunction due to a dysregulated host response to infection. The performance …		 CHRISTOPHER W SEYMOUR et. al.
2016 7 Plastic And Reconstructive Surgery
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 John Staige Davis;
2016 8 Trends In Obesity Prevalence Among Children And Adolescents In The United States, 1988-1994 Through 2013-2014
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Abstract: Previous analyses of obesity trends among children and adolescents showed an increase between 1988-1994 and 1999-2000, but no change between 2003-2004 and 2011-2012, except for a …		 CYNTHIA L OGDEN et. al.
2016 9 Erectile Dysfunction
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 Bobby B Najari; James A Kashanian;
2016 10 Screening For Colorectal Cancer: US Preventive Services Task Force Recommendation Statement
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Abstract: Colorectal cancer is the second leading cause of cancer death in the United States. In 2016, an estimated 134,000 persons will be diagnosed with the disease, and about 49,000 will …		 KIRSTEN BIBBINS-DOMINGO et. al.
2015 1 Nonalcoholic Fatty Liver Disease: A Systematic Review
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Abstract: Nonalcoholic fatty liver disease and its subtype nonalcoholic steatohepatitis affect approximately 30% and 5%, respectively, of the US population. In patients with nonalcoholic …		 Mary E Rinella;
2015 2 Transfusion Of Plasma, Platelets, And Red Blood Cells In A 1:1:1 Vs A 1:1:2 Ratio And Mortality In Patients With Severe Trauma: The PROPPR Randomized Clinical Trial
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Abstract: Severely injured patients experiencing hemorrhagic shock often require massive transfusion. Earlier transfusion with higher blood product ratios (plasma, platelets, and red blood …		 JOHN B HOLCOMB et. al.
2015 3 Comparison Of MR/ultrasound Fusion-guided Biopsy With Ultrasound-guided Biopsy For The Diagnosis Of Prostate Cancer
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Abstract: Targeted magnetic resonance (MR)/ultrasound fusion prostate biopsy has been shown to detect prostate cancer. The implications of targeted biopsy alone vs standard extended-sextant …		 M MINHAJ SIDDIQUI et. al.
2015 4 Cannabinoids For Medical Use: A Systematic Review And Meta-analysis
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Abstract: Cannabis and cannabinoid drugs are widely used to treat disease or alleviate symptoms, but their efficacy for specific indications is not clear. To conduct a systematic review of …		 PENNY F WHITING et. al.
2015 5 Preferred Reporting Items for Systematic Review and Meta-Analyses of Individual Participant Data: The PRISMA-IPD Statement
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Abstract: Systematic reviews and meta-analyses of individual participant data (IPD) aim to collect, check, and reanalyze individual-level data from all studies addressing a particular …		 LESLEY A STEWART et. al.
2015 6 Prevalence Of Cerebral Amyloid Pathology In Persons Without Dementia: A Meta-analysis
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Abstract: Cerebral amyloid-β aggregation is an early pathological event in Alzheimer disease (AD), starting decades before dementia onset. Estimates of the prevalence of amyloid pathology …		 WILLEMIJN J JANSEN et. al.
2015 7 Prevalence Of The Metabolic Syndrome In The United States, 2003-2012
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 Maria Aguilar; Taft Bhuket; Sharon Torres; Benny Liu; Robert J Wong;
2015 8 Prevalence Of And Trends In Diabetes Among Adults In The United States, 1988-2012
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Abstract: Previous studies have shown increasing prevalence of diabetes in the United States. New US data are available to estimate prevalence of and trends in diabetes. To estimate the …		 Andy Menke; Sarah Casagrande; Linda Geiss; Catherine C Cowie;
2015 9 Trends In Care Practices, Morbidity, And Mortality Of Extremely Preterm Neonates, 1993-2012
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Abstract: Extremely preterm infants contribute disproportionately to neonatal morbidity and mortality. To review 20-year trends in maternal/neonatal care, complications, and mortality among …		 BARBARA J STOLL et. al.
2015 10 Breast Cancer Screening For Women At Average Risk: 2015 Guideline Update From The American Cancer Society
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Abstract: Breast cancer is a leading cause of premature mortality among US women. Early detection has been shown to be associated with reduced breast cancer morbidity and mortality. To …		 KEVIN C OEFFINGER et. al.
2014 1 Prevalence Of Childhood And Adult Obesity In The United States, 2011-2012
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Abstract: More than one-third of adults and 17% of youth in the United States are obese, although the prevalence remained stable between 2003-2004 and 2009-2010. To provide the most recent …		 Cynthia L Ogden; Margaret D Carroll; Brian K Kit; Katherine M Flegal;
2014 2 Multiple Comparison Procedures
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 Jing Cao; Song Zhang;
2014 3 The Pathophysiology And Treatment Of Glaucoma: A Review
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Abstract: Glaucoma is a worldwide leading cause of irreversible vision loss. Because it may be asymptomatic until a relatively late stage, diagnosis is frequently delayed. A general …		 Robert N Weinreb; Tin Aung; Felipe A Medeiros;
2014 4 Smoking Prevalence And Cigarette Consumption In 187 Countries, 1980-2012
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Abstract: Tobacco is a leading global disease risk factor. Understanding national trends in prevalence and consumption is critical for prioritizing action and evaluating tobacco control …		 MARIE NG et. al.
2014 5 Mortality Related To Severe Sepsis And Septic Shock Among Critically Ill Patients In Australia And New Zealand, 2000-2012
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Abstract: Severe sepsis and septic shock are major causes of mortality in intensive care unit (ICU) patients. It is unknown whether progress has been made in decreasing their mortality …		 Kirsi-Maija Kaukonen; Michael Bailey; Satoshi Suzuki; David Pilcher; Rinaldo Bellomo;
2014 6 Using Multiplexed Assays Of Oncogenic Drivers In Lung Cancers To Select Targeted Drugs
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Abstract: Targeting oncogenic drivers (genomic alterations critical to cancer development and maintenance) has transformed the care of patients with lung adenocarcinomas. The Lung Cancer …		 MARK G KRIS et. al.
2014 7 Molecular Findings Among Patients Referred For Clinical Whole-exome Sequencing
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Abstract: Clinical whole-exome sequencing is increasingly used for diagnostic evaluation of patients with suspected genetic disorders. To perform clinical whole-exome sequencing and report …		 YAPING YANG et. al.
2014 8 Prevalence Of Type 1 And Type 2 Diabetes Among Children And Adolescents From 2001 To 2009
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Abstract: Despite concern about an epidemic, there are limited data on trends in prevalence of either type 1 or type 2 diabetes across US race and ethnic groups. To estimate changes in …		 DANA DABELEA et. al.
2014 9 Prevalence Of Obesity In The United States
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 Lawrence J Appel;
2014 10 Caregiver Burden: A Clinical Review
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Abstract: Caregiver burden may result from providing care for patients with chronic illness. It can occur in any of the 43.5 million individuals providing support to midlife and older …		 Ronald D Adelman; Lyubov L Tmanova; Diana Delgado; Sarah Dion; Mark S Lachs;
2013 1 2014 Evidence-based Guideline For The Management Of High Blood Pressure In Adults: Report From The Panel Members Appointed To The Eighth Joint National Committee (JNC 8)
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Abstract: Hypertension is the most common condition seen in primary care and leads to myocardial infarction, stroke, renal failure, and death if not detected early and treated …		 PAUL A JAMES et. al.
2013 2 Association Of All-cause Mortality With Overweight And Obesity Using Standard Body Mass Index Categories: A Systematic Review And Meta-analysis
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Abstract: Estimates of the relative mortality risks associated with normal weight, overweight, and obesity may help to inform decision making in the clinical setting. To perform a …		 Katherine M Flegal; Brian K Kit; Heather Orpana; Barry I Graubard;
2013 3 Prevalence And Control Of Diabetes In Chinese Adults
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Abstract: Noncommunicable chronic diseases have become the leading causes of mortality and disease burden worldwide. To investigate the prevalence of diabetes and glycemic control in the …		 YU XU et. al.
2013 4 The State Of US Health, 1990-2010: Burden Of Diseases, Injuries, And Risk Factors
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Abstract: Understanding the major health problems in the United States and how they are changing over time is critical for informing national health policy. To measure the burden of …		 CHRISTOPHER J L MURRAY et. al.
2013 5 Glioblastoma And Other Malignant Gliomas: A Clinical Review
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Abstract: Glioblastomas and malignant gliomas are the most common primary malignant brain tumors, with an annual incidence of 5.26 per 100,000 population or 17,000 new diagnoses per year. …		 Antonio Omuro; Lisa M DeAngelis;
2013 6 The Inevitable Application Of Big Data To Health Care
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 Travis B Murdoch; Allan S Detsky;
2013 7 Prevalence, Awareness, Treatment, And Control Of Hypertension In Rural And Urban Communities In High-, Middle-, And Low-income Countries
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Abstract: Hypertension is the most important preventable cause of morbidity and mortality globally, yet there are relatively few data collected using standardized methods. To examine …		 CLARA K CHOW et. al.
2013 8 Adjuvant Chemotherapy With Gemcitabine And Long-term Outcomes Among Patients With Resected Pancreatic Cancer: The CONKO-001 Randomized Trial
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Abstract: The prognosis for patients with pancreatic cancer is poor, even after resection with curative intent. Gemcitabine-based chemotherapy is standard treatment for advanced pancreatic …		 HELMUT OETTLE et. al.
2013 9 Acute Skeletal Muscle Wasting In Critical Illness
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Abstract: Survivors of critical illness demonstrate skeletal muscle wasting with associated functional impairment. To perform a comprehensive prospective characterization of skeletal muscle …		 ZUDIN A PUTHUCHEARY et. al.
2013 10 Menopausal Hormone Therapy And Health Outcomes During The Intervention And Extended Poststopping Phases Of The Women’s Health Initiative Randomized Trials
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Abstract: Menopausal hormone therapy continues in clinical use but questions remain regarding its risks and benefits for chronic disease prevention. To report a comprehensive, integrated …		 JOANN E MANSON et. al.
2012 1 Acute Respiratory Distress Syndrome: The Berlin Definition
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Abstract: The acute respiratory distress syndrome (ARDS) was defined in 1994 by the American-European Consensus Conference (AECC); since then, issues regarding the reliability and validity …		 V MARCO RANIERI et. al.
2012 2 Prevalence Of Obesity And Trends In The Distribution Of Body Mass Index Among US Adults, 1999-2010
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Abstract: Between 1980 and 1999, the prevalence of adult obesity (body mass index [BMI] ≥30) increased in the United States and the distribution of BMI changed. More recent data suggested a …		 Katherine M Flegal; Margaret D Carroll; Brian K Kit; Cynthia L Ogden;
2012 3 Prevalence Of Obesity And Trends In Body Mass Index Among US Children And Adolescents, 1999-2010
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Abstract: The prevalence of childhood obesity increased in the 1980s and 1990s but there were no significant changes in prevalence between 1999-2000 and 2007-2008 in the United States. To …		 Cynthia L Ogden; Margaret D Carroll; Brian K Kit; Katherine M Flegal;
2012 4 Reporting Of Noninferiority And Equivalence Randomized Trials: Extension Of The CONSORT 2010 Statement
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Abstract: The CONSORT (Consolidated Standards of Reporting Trials) Statement, which includes a checklist and a flow diagram, is a guideline developed to help authors improve the reporting …		 GILDA PIAGGIO et. al.
2012 5 Association Between Sustained Virological Response And All-cause Mortality Among Patients With Chronic Hepatitis C And Advanced Hepatic Fibrosis
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Abstract: Chronic hepatitis C virus (HCV) infection outcomes include liver failure, hepatocellular carcinoma (HCC), and liver-related death. To assess the association between sustained …		 ADRIAAN J VAN DER MEER et. al.
2012 6 Eliminating Waste In US Health Care
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Abstract: The need is urgent to bring US health care costs into a sustainable range for both public and private payers. Commonly, programs to contain costs use cuts, such as reductions in …		 Donald M Berwick; Andrew D Hackbarth;
2012 7 Bariatric Surgery And Long-term Cardiovascular Events
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Abstract: Obesity is a risk factor for cardiovascular events. Weight loss might protect against cardiovascular events, but solid evidence is lacking. To study the association between …		 LARS SJÖSTRÖM et. al.
2012 8 Association Between Omega-3 Fatty Acid Supplementation And Risk Of Major Cardiovascular Disease Events: A Systematic Review And Meta-analysis
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Abstract: Considerable controversy exists regarding the association of omega-3 polyunsaturated fatty acids (PUFAs) and major cardiovascular end points. To assess the role of omega-3 …		 Evangelos C Rizos; Evangelia E Ntzani; Eftychia Bika; Michael S Kostapanos; Moses S Elisaf;
2012 9 Benefits And Harms Of CT Screening For Lung Cancer: A Systematic Review
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Abstract: Lung cancer is the leading cause of cancer death. Most patients are diagnosed with advanced disease, resulting in a very low 5-year survival. Screening may reduce the risk of …		 PETER B BACH et. al.
2012 10 Association Between A Chloride-liberal Vs Chloride-restrictive Intravenous Fluid Administration Strategy And Kidney Injury In Critically Ill Adults
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Abstract: Administration of traditional chloride-liberal intravenous fluids may precipitate acute kidney injury (AKI). To assess the association of a chloride-restrictive (vs …		 NOR’AZIM MOHD YUNOS et. al.
2011 1 Gait Speed And Survival In Older Adults
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Abstract: Survival estimates help individualize goals of care for geriatric patients, but life tables fail to account for the great variability in survival. Physical performance measures, …		 STEPHANIE STUDENSKI et. al.
2011 2 Axillary Dissection Vs No Axillary Dissection In Women With Invasive Breast Cancer And Sentinel Node Metastasis: A Randomized Clinical Trial
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Abstract: Sentinel lymph node dissection (SLND) accurately identifies nodal metastasis of early breast cancer, but it is not clear whether further nodal dissection affects survival. To …		 ARMANDO E GIULIANO et. al.
2011 3 Risk Prediction Models For Hospital Readmission: A Systematic Review
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Abstract: Predicting hospital readmission risk is of great interest to identify which patients would benefit most from care transition interventions, as well as to risk-adjust readmission …		 DEVAN KANSAGARA et. al.
2011 4 Risk Of Incident Diabetes With Intensive-dose Compared With Moderate-dose Statin Therapy: A Meta-analysis
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Abstract: A recent meta-analysis demonstrated that statin therapy is associated with excess risk of developing diabetes mellitus. To investigate whether intensive-dose statin therapy is …		 DAVID PREISS et. al.
2011 5 Fibroblast Growth Factor 23 And Risks Of Mortality And End-stage Renal Disease In Patients With Chronic Kidney Disease
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Abstract: A high level of the phosphate-regulating hormone fibroblast growth factor 23 (FGF-23) is associated with mortality in patients with end-stage renal disease, but little is known …		 TAMARA ISAKOVA et. al.
2011 6 Standard- Vs High-dose Clopidogrel Based On Platelet Function Testing After Percutaneous Coronary Intervention: The GRAVITAS Randomized Trial
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Abstract: High platelet reactivity while receiving clopidogrel has been linked to cardiovascular events after percutaneous coronary intervention (PCI), but a treatment strategy for this …		 MATTHEW J PRICE et. al.
2011 7 Vitamin E And The Risk Of Prostate Cancer: The Selenium And Vitamin E Cancer Prevention Trial (SELECT)
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Abstract: The initial report of the Selenium and Vitamin E Cancer Prevention Trial (SELECT) found no reduction in risk of prostate cancer with either selenium or vitamin E supplements but a …		 ERIC A KLEIN et. al.
2011 8 Use Of Florbetapir-PET For Imaging Beta-amyloid Pathology
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Abstract: The ability to identify and quantify brain β-amyloid could increase the accuracy of a clinical diagnosis of Alzheimer disease. To determine if florbetapir F 18 positron emission …		 CHRISTOPHER M CLARK et. al.
2011 9 Spectrum of Cancer Risk Among US Solid Organ Transplant Recipients
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Abstract: Solid organ transplant recipients have elevated cancer risk due to immunosuppression and oncogenic viral infections. Because most prior research has concerned kidney recipients, …		 ERIC A ENGELS et. al.
2011 10 Effect Of Screening On Ovarian Cancer Mortality: The Prostate, Lung, Colorectal And Ovarian (PLCO) Cancer Screening Randomized Controlled Trial
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Abstract: Screening for ovarian cancer with cancer antigen 125 (CA-125) and transvaginal ultrasound has an unknown effect on mortality. To evaluate the effect of screening for ovarian …		 SAUNDRA S BUYS et. al.
2010 1 Prevalence And Trends In Obesity Among US Adults, 1999-2008
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Abstract: The prevalence of obesity increased in the United States between 1976-1980 and 1988-1994 and again between 1988-1994 and 1999-2000. To examine trends in obesity from 1999 through …		 Katherine M Flegal; Margaret D Carroll; Cynthia L Ogden; Lester R Curtin;
2010 2 Prevalence Of High Body Mass Index In US Children And Adolescents, 2007-2008
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Abstract: The prevalence of high body mass index (BMI) among children and adolescents in the United States appeared to plateau between 1999 and 2006. To provide the most recent estimates of …		 Cynthia L Ogden; Margaret D Carroll; Lester R Curtin; Molly M Lamb; Katherine M Flegal;
2010 3 Antiretroviral Treatment Of Adult HIV Infection: 2010 Recommendations Of The International AIDS Society-USA Panel
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Abstract: Recent data regarding the consequences of untreated human immunodeficiency virus (HIV) infection and the expansion of treatment choices for antiretroviral-naive and …		 MELANIE A THOMPSON et. al.
2010 4 Stereotactic Body Radiation Therapy For Inoperable Early Stage Lung Cancer
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Abstract: Patients with early stage but medically inoperable lung cancer have a poor rate of primary tumor control (30%-40%) and a high rate of mortality (3-year survival, 20%-35%) with …		 ROBERT TIMMERMAN et. al.
2010 5 Gait Analysis: Normal and Pathological Function
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 Alfred D. Grant;
2010 6 US Trends In Prevalence, Awareness, Treatment, And Control Of Hypertension, 1988-2008
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Abstract: Hypertension is a major risk factor for cardiovascular disease and treatment and control of hypertension reduces risk. The Healthy People 2010 goal was to achieve blood pressure …		 Brent M Egan; Yumin Zhao; R Neal Axon;
2010 7 Antidepressant Drug Effects And Depression Severity: A Patient-level Meta-analysis
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Abstract: Antidepressant medications represent the best established treatment for major depressive disorder, but there is little evidence that they have a specific pharmacological effect …		 JAY C FOURNIER et. al.
2010 8 Delirium In Elderly Patients And The Risk Of Postdischarge Mortality, Institutionalization, And Dementia: A Meta-analysis
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Abstract: Delirium is a common and serious complication in elderly patients. Evidence suggests that delirium is associated with long-term poor outcome but delirium often occurs in …		 JOOST WITLOX et. al.
2010 9 Annual High-dose Oral Vitamin D And Falls And Fractures In Older Women: A Randomized Controlled Trial
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Abstract: Improving vitamin D status may be an important modifiable risk factor to reduce falls and fractures; however, adherence to daily supplementation is typically poor. To determine …		 KERRIE M SANDERS et. al.
2010 10 Genome-wide Analysis Of Genetic Loci Associated With Alzheimer Disease
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Abstract: Genome-wide association studies (GWAS) have recently identified CLU, PICALM, and CR1 as novel genes for late-onset Alzheimer disease (AD). To identify and strengthen additional …		 SUDHA SESHADRI et. al.