Most Influential NATURE Papers (2021-08)
Nature is a British weekly scientific journal founded and based in London, England. As a multidisciplinary publication, Nature features peer-reviewed research from a variety of academic disciplines, mainly in science, technology, and the natural sciences. Paper Digest Team analyze all papers published on NATURE in the past years, and presents the 10 most influential papers for each year (based on when the paper became available online). This ranking list is automatically constructed based upon citations from both research papers and granted patents, and will be frequently updated to reflect the most recent changes. To find the most influential papers from other conferences/journals, visit Best Paper Digest page. Note: the most influential papers may or may not include the papers that won the best paper awards. (Last updated on: 2021-09-01)
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TABLE 1: Most Influential NATURE Papers (2021-08)
| Year | Rank | Paper | Author(s) |
|---|---|---|---|
| 2020 | 1 | A Pneumonia Outbreak Associated with A New Coronavirus of Probable Bat Origin IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Since the outbreak of severe acute respiratory syndrome (SARS) 18 years ago, a large number of SARS-related coronaviruses (SARSr-CoVs) have been discovered in their natural … |
PENG ZHOU et. al. |
| 2020 | 2 | A New Coronavirus Associated with Human Respiratory Disease in China IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Emerging infectious diseases, such as severe acute respiratory syndrome (SARS) and Zika virus disease, present a major threat to public health . Despite intense research efforts, … |
FAN WU et. al. |
| 2020 | 3 | Virological Assessment of Hospitalized Patients with COVID-2019 IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Coronavirus disease 2019 (COVID-19) is an acute infection of the respiratory tract that emerged in late 2019 . Initial outbreaks in China involved 13.8% of cases with severe … |
ROMAN WÖLFEL et. al. |
| 2020 | 4 | Structure of The SARS-CoV-2 Spike Receptor-binding Domain Bound to The ACE2 Receptor IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: A new and highly pathogenic coronavirus (severe acute respiratory syndrome coronavirus-2, SARS-CoV-2) caused an outbreak in Wuhan city, Hubei province, China, starting from … |
JUN LAN et. al. |
| 2020 | 5 | Structural Basis of Receptor Recognition By SARS-CoV-2 IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: A novel severe acute respiratory syndrome (SARS)-like coronavirus (SARS-CoV-2) recently emerged and is rapidly spreading in humans, causing COVID-19 . A key to tackling this … |
JIAN SHANG et. al. |
| 2020 | 6 | A SARS-CoV-2 Protein Interaction Map Reveals Targets for Drug-Repurposing IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: A newly described coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is the causative agent of coronavirus disease 2019 (COVID-19), has infected … |
DAVID E. GORDON et. al. |
| 2020 | 7 | Factors Associated with COVID-19-related Death Using OpenSAFELY IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Coronavirus disease 2019 (COVID-19) has rapidly affected mortality worldwide . There is unprecedented urgency to understand who is most at risk of severe outcomes, and this … |
ELIZABETH J WILLIAMSON et. al. |
| 2020 | 8 | Estimating The Effects of Non-pharmaceutical Interventions on COVID-19 in Europe IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Following the detection of the new coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its spread outside of China, Europe has experienced large epidemics … |
SETH FLAXMAN et. al. |
| 2020 | 9 | The Mutational Constraint Spectrum Quantified from Variation in 141,456 Humans IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Genetic variants that inactivate protein-coding genes are a powerful source of information about the phenotypic consequences of gene disruption: genes that are crucial for the … |
KONRAD J KARCZEWSKI et. al. |
| 2020 | 10 | Structure of Mpro from SARS-CoV-2 and Discovery of Its Inhibitors IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: A new coronavirus, known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is the aetiological agent responsible for the 2019–2020 viral pneumonia outbreak of … |
ZHENMING JIN et. al. |
| 2019 | 1 | Quantum Supremacy Using A Programmable Superconducting Processor IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The promise of quantum computers is that certain computational tasks might be executed exponentially faster on a quantum processor than on a classical processor . A fundamental … |
FRANK ARUTE et. al. |
| 2019 | 2 | The Structure of DNA IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details |
Georgina Ferry; |
| 2019 | 3 | Scientists Rise Up Against Statistical Significance IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details |
Valentin Amrhein; Sander Greenland; Blake McShane; |
| 2019 | 4 | Grandmaster Level In StarCraft II Using Multi-agent Reinforcement Learning IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Many real-world applications require artificial agents to compete and coordinate with other agents in complex environments. As a stepping stone to this goal, the domain of … |
ORIOL VINYALS et. al. |
| 2019 | 5 | Efficient, Stable And Scalable Perovskite Solar Cells Using Poly(3-hexylthiophene) IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Perovskite solar cells typically comprise electron- and hole-transport materials deposited on each side of a perovskite active layer. So far, only two organic hole-transport … |
EUI HYUK JUNG et. al. |
| 2019 | 6 | Search-and-replace Genome Editing Without Double-strand Breaks or Donor DNA IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Most genetic variants that contribute to disease are challenging to correct efficiently and without excess byproducts . Here we describe prime editing, a versatile and precise … |
ANDREW V ANZALONE et. al. |
| 2019 | 7 | Deep Learning And Process Understanding For Data-driven Earth System Science IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Machine learning approaches are increasingly used to extract patterns and insights from the ever-increasing stream of geospatial data, but current approaches may not be optimal … |
MARKUS REICHSTEIN et. al. |
| 2019 | 8 | Next-generation Characterization of The Cancer Cell Line Encyclopedia IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Large panels of comprehensively characterized human cancer models, including the Cancer Cell Line Encyclopedia (CCLE), have provided a rigorous framework with which to study … |
MAHMOUD GHANDI et. al. |
| 2019 | 9 | The Single Cell Transcriptional Landscape of Mammalian Organogenesis IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Mammalian organogenesis is a remarkable process. Within a short timeframe, the cells of the three germ layers transform into an embryo that includes most of the major internal and … |
JUNYUE CAO et. al. |
| 2019 | 10 | The Eye IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details |
Sujata Gupta; |
| 2018 | 1 | Unconventional Superconductivity In Magic-angle Graphene Superlattices IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The behaviour of strongly correlated materials, and in particular unconventional superconductors, has been studied extensively for decades, but is still not well understood. This … |
YUAN CAO et. al. |
| 2018 | 2 | The UK Biobank Resource With Deep Phenotyping And Genomic Data IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The UK Biobank project is a prospective cohort study with deep genetic and phenotypic data collected on approximately 500,000 individuals from across the United Kingdom, aged … |
CLARE BYCROFT et. al. |
| 2018 | 3 | Correlated Insulator Behaviour At Half-filling In Magic-angle Graphene Superlattices IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: A van der Waals heterostructure is a type of metamaterial that consists of vertically stacked two-dimensional building blocks held together by the van der Waals forces between the … |
YUAN CAO et. al. |
| 2018 | 4 | Perovskite Light-emitting Diodes With External Quantum Efficiency Exceeding 20 Per Cent IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Metal halide perovskite materials are an emerging class of solution-processable semiconductors with considerable potential for use in optoelectronic devices . For example, … |
KEBIN LIN et. al. |
| 2018 | 5 | RNA Velocity Of Single Cells IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: RNA abundance is a powerful indicator of the state of individual cells. Single-cell RNA sequencing can reveal RNA abundance with high quantitative accuracy, sensitivity and … |
GIOELE LA MANNO et. al. |
| 2018 | 6 | Environment Dominates Over Host Genetics In Shaping Human Gut Microbiota IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Human gut microbiome composition is shaped by multiple factors but the relative contribution of host genetics remains elusive. Here we examine genotype and microbiome data from … |
DAPHNA ROTHSCHILD et. al. |
| 2018 | 7 | Machine Learning For Molecular And Materials Science IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Here we summarize recent progress in machine learning for the chemical sciences. We outline machine-learning techniques that are suitable for addressing research questions in this … |
Keith T Butler; Daniel W Davies; Hugh Cartwright; Olexandr Isayev; Aron Walsh; |
| 2018 | 8 | DNA Methylation-based Classification of Central Nervous System Tumours IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Accurate pathological diagnosis is crucial for optimal management of patients with cancer. For the approximately 100 known tumour types of the central nervous system, … |
DAVID CAPPER et. al. |
| 2018 | 9 | Exosomal PD-L1 Contributes To Immunosuppression And Is Associated With Anti-PD-1 Response IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Tumour cells evade immune surveillance by upregulating the surface expression of programmed death-ligand 1 (PD-L1), which interacts with programmed death-1 (PD-1) receptor on T … |
GANG CHEN et. al. |
| 2018 | 10 | Options for Keeping The Food System Within Environmental Limits IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The food system is a major driver of climate change, changes in land use, depletion of freshwater resources, and pollution of aquatic and terrestrial ecosystems through excessive … |
MARCO SPRINGMANN et. al. |
| 2017 | 1 | Dermatologist-level Classification of Skin Cancer with Deep Neural Networks IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Skin cancer, the most common human malignancy, is primarily diagnosed visually, beginning with an initial clinical screening and followed potentially by dermoscopic analysis, a … |
ANDRE ESTEVA et. al. |
| 2017 | 2 | Mastering The Game Of Go Without Human Knowledge IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: A long-standing goal of artificial intelligence is an algorithm that learns, tabula rasa, superhuman proficiency in challenging domains. Recently, AlphaGo became the first program … |
DAVID SILVER et. al. |
| 2017 | 3 | Neurotoxic Reactive Astrocytes Are Induced By Activated Microglia IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Reactive astrocytes are strongly induced by central nervous system (CNS) injury and disease, but their role is poorly understood. Here we show that a subtype of reactive … |
SHANE A LIDDELOW et. al. |
| 2017 | 4 | Layer-dependent Ferromagnetism In A Van Der Waals Crystal Down To The Monolayer Limit IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Since the discovery of graphene, the family of two-dimensional materials has grown, displaying a broad range of electronic properties. Recent additions include semiconductors with … |
BEVIN HUANG et. al. |
| 2017 | 5 | Discovery Of Intrinsic Ferromagnetism In Two-dimensional Van Der Waals Crystals IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The realization of long-range ferromagnetic order in two-dimensional van der Waals crystals, combined with their rich electronic and optical properties, could lead to new … |
CHENG GONG et. al. |
| 2017 | 6 | An Immunogenic Personal Neoantigen Vaccine For Patients With Melanoma IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Effective anti-tumour immunity in humans has been associated with the presence of T cells directed at cancer neoantigens, a class of HLA-bound peptides that arise from … |
PATRICK A OTT et. al. |
| 2017 | 7 | Personalized RNA Mutanome Vaccines Mobilize Poly-specific Therapeutic Immunity Against Cancer IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: T cells directed against mutant neo-epitopes drive cancer immunity. However, spontaneous immune recognition of mutations is inefficient. We recently introduced the concept of … |
UGUR SAHIN et. al. |
| 2017 | 8 | Probing Many-body Dynamics On A 51-atom Quantum Simulator IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Controllable, coherent many-body systems can provide insights into the fundamental properties of quantum matter, enable the realization of new quantum phases and could ultimately … |
HANNES BERNIEN et. al. |
| 2017 | 9 | Hardware-efficient Variational Quantum Eigensolver For Small Molecules And Quantum Magnets IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Quantum computers can be used to address electronic-structure problems and problems in materials science and condensed matter physics that can be formulated as interacting … |
ABHINAV KANDALA et. al. |
| 2017 | 10 | The Biology And Management Of Non-small Cell Lung Cancer IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Important advancements in the treatment of non-small cell lung cancer (NSCLC) have been achieved over the past two decades, increasing our understanding of the disease biology and … |
Roy S Herbst; Daniel Morgensztern; Chris Boshoff; |
| 2016 | 1 | Genetic Effects On Gene Expression Across Human Tissues IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Characterization of the molecular function of the human genome and its variation across individuals is essential for identifying the cellular mechanisms that underlie human … |
ALEXIS BATTLE et. al. |
| 2016 | 2 | A Multi-modal Parcellation Of Human Cerebral Cortex IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Understanding the amazingly complex human cerebral cortex requires a map (or parcellation) of its major subdivisions, known as cortical areas. Making an accurate areal map has … |
MATTHEW F GLASSER et. al. |
| 2016 | 3 | Programmable Editing Of A Target Base In Genomic DNA Without Double-stranded DNA Cleavage IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Current genome-editing technologies introduce double-stranded (ds) DNA breaks at a target locus as the first step to gene correction. Although most genetic diseases arise from … |
Alexis C Komor; Yongjoo B Kim; Michael S Packer; John A Zuris; David R Liu; |
| 2016 | 4 | 1,500 Scientists Lift The Lid On Reproducibility IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details |
Monya Baker; |
| 2016 | 5 | Genomic Analyses Identify Molecular Subtypes of Pancreatic Cancer IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Integrated genomic analysis of 456 pancreatic ductal adenocarcinomas identified 32 recurrently mutated genes that aggregate into 10 pathways: KRAS, TGF-β, WNT, NOTCH, ROBO/SLIT … |
PETER BAILEY et. al. |
| 2016 | 6 | Global Warming And Recurrent Mass Bleaching Of Corals IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: During 2015-2016, record temperatures triggered a pan-tropical episode of coral bleaching, the third global-scale event since mass bleaching was first documented in the 1980s. … |
TERRY P HUGHES et. al. |
| 2016 | 7 | High-resolution Mapping Of Global Surface Water And Its Long-term Changes IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The location and persistence of surface water (inland and coastal) is both affected by climate and human activity and affects climate, biological diversity and human wellbeing. … |
Jean-François Pekel; Andrew Cottam; Noel Gorelick; Alan S Belward; |
| 2016 | 8 | Metastable High-entropy Dual-phase Alloys Overcome The Strength-ductility Trade-off IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Metals have been mankind’s most essential materials for thousands of years; however, their use is affected by ecological and economical concerns. Alloys with higher strength and … |
Zhiming Li; Konda Gokuldoss Pradeep; Yun Deng; Dierk Raabe; Cemal Cem Tasan; |
| 2016 | 9 | Naturally Occurring P16Ink4a-positive Cells Shorten Healthy Lifespan IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Cellular senescence, a stress-induced irreversible growth arrest often characterized by expression of p16Ink4a (encoded by the Ink4a/Arf locus, also known as Cdkn2a) and a … |
DARREN J. BAKER et. al. |
| 2016 | 10 | Schizophrenia Risk from Complex Variation of Complement Component 4 IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Schizophrenia is a heritable brain illness with unknown pathogenic mechanisms. Schizophrenia’s strongest genetic association at a population level involves variation in the major … |
ASWIN SEKAR et. al. |
| 2015 | 1 | Mastering The Game Of Go With Deep Neural Networks And Tree Search IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The game of Go has long been viewed as the most challenging of classic games for artificial intelligence owing to its enormous search space and the difficulty of evaluating board … |
DAVID SILVER et. al. |
| 2015 | 2 | A Global Reference for Human Genetic Variation IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The 1000 Genomes Project set out to provide a comprehensive description of common human genetic variation by applying whole-genome sequencing to a diverse set of individuals from … |
ADAM AUTON et. al. |
| 2015 | 3 | Compositional Engineering Of Perovskite Materials For High-performance Solar Cells IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Of the many materials and methodologies aimed at producing low-cost, efficient photovoltaic cells, inorganic-organic lead halide perovskite materials appear particularly promising … |
NAM JOONG JEON et. al. |
| 2015 | 4 | Biomaterials IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details |
Herb Brody; |
| 2015 | 5 | Tumour Exosome Integrins Determine Organotropic Metastasis IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Ever since Stephen Paget’s 1889 hypothesis, metastatic organotropism has remained one of cancer’s greatest mysteries. Here we demonstrate that exosomes from mouse and human lung-, … |
AYUKO HOSHINO et. al. |
| 2015 | 6 | In Vivo Genome Editing Using Staphylococcus Aureus Cas9 IF:10 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The RNA-guided endonuclease Cas9 has emerged as a versatile genome-editing platform. However, the size of the commonly used Cas9 from Streptococcus pyogenes (SpCas9) limits its … |
F ANN RAN et. al. |
| 2015 | 7 | Fully Integrated Wearable Sensor Arrays For Multiplexed In Situ Perspiration Analysis IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Wearable sensor technologies are essential to the realization of personalized medicine through continuously monitoring an individual’s state of health. Sampling human sweat, which … |
WEI GAO et. al. |
| 2015 | 8 | Cleavage of GSDMD By Inflammatory Caspases Determines Pyroptotic Cell Death IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Inflammatory caspases (caspase-1, -4, -5 and -11) are critical for innate defences. Caspase-1 is activated by ligands of various canonical inflammasomes, and caspase-4, -5 and -11 … |
JIANJIN SHI et. al. |
| 2015 | 9 | The Effect Of Malaria Control On Plasmodium Falciparum In Africa Between 2000 And 2015 IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Since the year 2000, a concerted campaign against malaria has led to unprecedented levels of intervention coverage across sub-Saharan Africa. Understanding the effect of this … |
S BHATT et. al. |
| 2015 | 10 | A New Antibiotic Kills Pathogens Without Detectable Resistance IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Antibiotic resistance is spreading faster than the introduction of new compounds into clinical practice, causing a public health crisis. Most antibiotics were produced by … |
LOSEE L LING et. al. |
| 2014 | 1 | Human-level Control Through Deep Reinforcement Learning IF:10 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The theory of reinforcement learning provides a normative account, deeply rooted in psychological and neuroscientific perspectives on animal behaviour, of how agents may optimize … |
VOLODYMYR MNIH et. al. |
| 2014 | 2 | Integrative Analysis Of 111 Reference Human Epigenomes IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The reference human genome sequence set the stage for studies of genetic variation and its association with human disease, but epigenomic studies lack a similar reference. To … |
ANSHUL KUNDAJE et. al. |
| 2014 | 3 | PD-1 Blockade Induces Responses By Inhibiting Adaptive Immune Resistance IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Therapies that target the programmed death-1 (PD-1) receptor have shown unprecedented rates of durable clinical responses in patients with various cancer types. One mechanism by … |
PAUL C TUMEH et. al. |
| 2014 | 4 | Predictive Correlates Of Response To The Anti-PD-L1 Antibody MPDL3280A In Cancer Patients IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The development of human cancer is a multistep process characterized by the accumulation of genetic and epigenetic alterations that drive or reflect tumour progression. These … |
ROY S HERBST et. al. |
| 2014 | 5 | The Contribution Of Outdoor Air Pollution Sources To Premature Mortality On A Global Scale IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Assessment of the global burden of disease is based on epidemiological cohort studies that connect premature mortality to a wide range of causes, including the long-term health … |
J Lelieveld; J S Evans; M Fnais; D Giannadaki; A Pozzer; |
| 2014 | 6 | High Secondary Aerosol Contribution To Particulate Pollution During Haze Events In China IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Rapid industrialization and urbanization in developing countries has led to an increase in air pollution, along a similar trajectory to that previously experienced by the … |
RU-JIN HUANG et. al. |
| 2014 | 7 | Discovery and Saturation Analysis of Cancer Genes Across 21 Tumor Types IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Although a few cancer genes are mutated in a high proportion of tumours of a given type (>20%), most are mutated at intermediate frequencies (2–20%). To explore the feasibility of … |
MICHAEL S. LAWRENCE et. al. |
| 2014 | 8 | Design, Fabrication And Control Of Soft Robots IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Conventionally, engineers have employed rigid materials to fabricate precise, predictable robotic systems, which are easily modelled as rigid members connected at discrete joints. … |
Daniela Rus; Michael T Tolley; |
| 2014 | 9 | MPDL3280A (anti-PD-L1) Treatment Leads To Clinical Activity In Metastatic Bladder Cancer IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: There have been no major advances for the treatment of metastatic urothelial bladder cancer (UBC) in the last 30 years. Chemotherapy is still the standard of care. Patient … |
THOMAS POWLES et. al. |
| 2014 | 10 | An Overview Of N-heterocyclic Carbenes IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The successful isolation and characterization of an N-heterocyclic carbene in 1991 opened up a new class of organic compounds for investigation. From these beginnings as academic … |
Matthew N Hopkinson; Christian Richter; Michael Schedler; Frank Glorius; |
| 2013 | 1 | Sequential Deposition As A Route To High-performance Perovskite-sensitized Solar Cells IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Following pioneering work, solution-processable organic-inorganic hybrid perovskites-such as CH3NH3PbX3 (X = Cl, Br, I)-have attracted attention as light-harvesting materials for … |
JULIAN BURSCHKA et. al. |
| 2013 | 2 | Signatures Of Mutational Processes In Human Cancer IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: All cancers are caused by somatic mutations; however, understanding of the biological processes generating these mutations is limited. The catalogue of somatic mutations from a … |
LUDMIL B ALEXANDROV et. al. |
| 2013 | 3 | Efficient Planar Heterojunction Perovskite Solar Cells By Vapour Deposition IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Many different photovoltaic technologies are being developed for large-scale solar energy conversion. The wafer-based first-generation photovoltaic devices have been followed by … |
Mingzhen Liu; Michael B Johnston; Henry J Snaith; |
| 2013 | 4 | The Global Distribution And Burden Of Dengue IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Dengue is a systemic viral infection transmitted between humans by Aedes mosquitoes. For some patients, dengue is a life-threatening illness. There are currently no licensed … |
SAMIR BHATT et. al. |
| 2013 | 5 | Diet Rapidly And Reproducibly Alters The Human Gut Microbiome IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Long-term dietary intake influences the structure and activity of the trillions of microorganisms residing in the human gut, but it remains unclear how rapidly and reproducibly … |
LAWRENCE A DAVID et. al. |
| 2013 | 6 | Van Der Waals Heterostructures IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Research on graphene and other two-dimensional atomic crystals is intense and is likely to remain one of the leading topics in condensed matter physics and materials science for … |
A K Geim; I V Grigorieva; |
| 2013 | 7 | Circular RNAs Are A Large Class Of Animal RNAs With Regulatory Potency IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse … |
SEBASTIAN MEMCZAK et. al. |
| 2013 | 8 | Natural RNA Circles Function As Efficient MicroRNA Sponges IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: MicroRNAs (miRNAs) are important post-transcriptional regulators of gene expression that act by direct base pairing to target sites within untranslated regions of messenger RNAs. … |
THOMAS B HANSEN et. al. |
| 2013 | 9 | Ultra-sensitive Fluorescent Proteins for Imaging Neuronal Activity IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Fluorescent calcium sensors are widely used to image neural activity. Using structure-based mutagenesis and neuron-based screening, we developed a family of ultrasensitive protein … |
TSAI-WEN CHEN et. al. |
| 2013 | 10 | Mutational Landscape And Significance Across 12 Major Cancer Types IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The Cancer Genome Atlas (TCGA) has used the latest sequencing and analysis methods to identify somatic variants across thousands of tumours. Here we present data and analytical … |
CYRIAC KANDOTH et. al. |
| 2012 | 1 | An Integrated Map of Genetic Variation from 1,092 Human Genomes IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: By characterizing the geographic and functional spectrum of human genetic variation, the 1000 Genomes Project aims to build a resource to help to understand the genetic … |
GONCALO R ABECASIS et. al. |
| 2012 | 2 | Comprehensive Molecular Portraits of Human Breast Tumors IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: We analysed primary breast cancers by genomic DNA copy number arrays, DNA methylation, exome sequencing, messenger RNA arrays, microRNA sequencing and reverse-phase protein … |
DANIEL C. KOBOLDT et. al. |
| 2012 | 3 | A Roadmap For Graphene IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Recent years have witnessed many breakthroughs in research on graphene (the first two-dimensional atomic crystal) as well as a significant advance in the mass production of this … |
K S NOVOSELOV et. al. |
| 2012 | 4 | Human Gut Microbiome Viewed Across Age And Geography IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Gut microbial communities represent one source of human genetic and metabolic diversity. To examine how gut microbiomes differ among human populations, here we characterize … |
TANYA YATSUNENKO et. al. |
| 2012 | 5 | The Cancer Cell Line Encyclopedia Enables Predictive Modeling of Anticancer Drug Sensitivity IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The systematic translation of cancer genomic data into knowledge of tumour biology and therapeutic possibilities remains challenging. Such efforts should be greatly aided by … |
JORDI BARRETINA et. al. |
| 2012 | 6 | Topological Domains In Mammalian Genomes Identified By Analysis Of Chromatin Interactions IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The spatial organization of the genome is intimately linked to its biological function, yet our understanding of higher order genomic structure is coarse, fragmented and … |
JESSE R DIXON et. al. |
| 2012 | 7 | Opportunities And Challenges For A Sustainable Energy Future IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Access to clean, affordable and reliable energy has been a cornerstone of the world’s increasing prosperity and economic growth since the beginning of the industrial revolution. … |
Steven Chu; Arun Majumdar; |
| 2012 | 8 | Biodiversity Loss And Its Impact On Humanity IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The most unique feature of Earth is the existence of life, and the most extraordinary feature of life is its diversity. Approximately 9 million types of plants, animals, protists … |
BRADLEY J CARDINALE et. al. |
| 2012 | 9 | The Genomic and Transcriptomic Architecture of 2,000 Breast Tumours Reveals Novel Subgroups IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The elucidation of breast cancer subgroups and their molecular drivers requires integrated views of the genome and transcriptome from representative numbers of patients. We … |
CHRISTINA CURTIS et. al. |
| 2012 | 10 | A Metagenome-wide Association Study Of Gut Microbiota In Type 2 Diabetes IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Assessment and characterization of gut microbiota has become a major research area in human disease, including type 2 diabetes, the most prevalent endocrine disease worldwide. To … |
JUNJIE QIN et. al. |
| 2011 | 1 | Solutions For A Cultivated Planet IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Increasing population and consumption are placing unprecedented demands on agriculture and natural resources. Today, approximately a billion people are chronically malnourished … |
JONATHAN A FOLEY et. al. |
| 2011 | 2 | Landscape Of Transcription In Human Cells IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Eukaryotic cells make many types of primary and processed RNAs that are found either in specific subcellular compartments or throughout the cells. A complete catalogue of these … |
SARAH DJEBALI et. al. |
| 2011 | 3 | Molecular Mechanisms And Clinical Applications Of Angiogenesis IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Blood vessels deliver oxygen and nutrients to every part of the body, but also nourish diseases such as cancer. Over the past decade, our understanding of the molecular mechanisms … |
Peter Carmeliet; Rakesh K Jain; |
| 2011 | 4 | Enterotypes Of The Human Gut Microbiome IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Our knowledge of species and functional composition of the human gut microbiome is rapidly increasing, but it is still based on very few cohorts and little is known about … |
MANIMOZHIYAN ARUMUGAM et. al. |
| 2011 | 5 | Persistence Of Soil Organic Matter As An Ecosystem Property IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Globally, soil organic matter (SOM) contains more than three times as much carbon as either the atmosphere or terrestrial vegetation. Yet it remains largely unknown why some SOM … |
MICHAEL W I SCHMIDT et. al. |
| 2011 | 6 | Gut Flora Metabolism of Phosphatidylcholine Promotes Cardiovascular Disease IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Metabolomics studies hold promise for the discovery of pathways linked to disease processes. Cardiovascular disease (CVD) represents the leading cause of death and morbidity … |
ZENENG WANG et. al. |
| 2011 | 7 | Progress And Challenges In Translating The Biology Of Atherosclerosis IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Atherosclerosis is a chronic disease of the arterial wall, and a leading cause of death and loss of productive life years worldwide. Research into the disease has led to many … |
Peter Libby; Paul M Ridker; Göran K Hansson; |
| 2011 | 8 | Cancer Immunotherapy Comes Of Age IF:10 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Activating the immune system for therapeutic benefit in cancer has long been a goal in immunology and oncology. After decades of disappointment, the tide has finally changed due … |
Ira Mellman; George Coukos; Glenn Dranoff; |
| 2011 | 9 | A Graphene-based Broadband Optical Modulator IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Integrated optical modulators with high modulation speed, small footprint and large optical bandwidth are poised to be the enabling devices for on-chip optical interconnects. … |
MING LIU et. al. |
| 2011 | 10 | Autophagy In Immunity And Inflammation IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Autophagy is an essential, homeostatic process by which cells break down their own components. Perhaps the most primordial function of this lysosomal degradation pathway is … |
Beth Levine; Noboru Mizushima; Herbert W Virgin; |
| 2010 | 1 | A Human Gut Microbial Gene Catalogue Established By Metagenomic Sequencing IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: To understand the impact of gut microbes on human health and well-being it is crucial to assess their genetic potential. Here we describe the Illumina-based metagenomic … |
JUNJIE QIN et. al. |
| 2010 | 2 | A Map Of Human Genome Variation From Population-scale Sequencing IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The 1000 Genomes Project aims to provide a deep characterization of human genome sequence variation as a foundation for investigating the relationship between genotype and … |
GONÇALO R ABECASIS et. al. |
| 2010 | 3 | The Next Generation Of Scenarios For Climate Change Research And Assessment IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Advances in the science and observation of climate change are providing a clearer understanding of the inherent variability of Earth’s climate system and its likely response to … |
RICHARD H MOSS et. al. |
| 2010 | 4 | Global Quantification Of Mammalian Gene Expression Control IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Gene expression is a multistep process that involves the transcription, translation and turnover of messenger RNAs and proteins. Although it is one of the most fundamental … |
BJÖRN SCHWANHÄUSSER et. al. |
| 2010 | 5 | Long Noncoding RNA HOTAIR Reprograms Chromatin State to Promote Cancer Metastasis IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Large intervening non-coding RNAs (lincRNAs) are pervasively transcribed in the genome yet their potential involvement in human disease is not well understood. Recent studies of … |
RAJNISH A. GUPTA et. al. |
| 2010 | 6 | Mammalian MicroRNAs Predominantly Act To Decrease Target MRNA Levels IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: MicroRNAs (miRNAs) are endogenous approximately 22-nucleotide RNAs that mediate important gene-regulatory events by pairing to the mRNAs of protein-coding genes to direct their … |
Huili Guo; Nicholas T Ingolia; Jonathan S Weissman; David P Bartel; |
| 2010 | 7 | Biological, Clinical And Population Relevance Of 95 Loci For Blood Lipids IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Plasma concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and triglycerides are among the most important risk factors … |
TANYA M TESLOVICH et. al. |
| 2010 | 8 | Genome Sequence of The Palaeopolyploid Soybean IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Soybean (Glycine max) is one of the most important crop plants for seed protein and oil content, and for its capacity to fix atmospheric nitrogen through symbioses with soil-borne … |
JEREMY SCHMUTZ et. al. |
| 2010 | 9 | Global Threats To Human Water Security And River Biodiversity IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Protecting the world’s freshwater resources requires diagnosing threats over a broad range of scales, from global to local. Here we present the first worldwide synthesis to … |
C J VÖRÖSMARTY et. al. |
| 2010 | 10 | Cancer-associated IDH1 Mutations Produce 2-hydroxyglutarate IF:10 Related Papers Related Patents Related Grants Related Orgs Related Experts Details |
LENNY DANG et. al. |