Most Influential CELL Papers (2022-02)
Cell is a peer-reviewed scientific journal publishing research papers across a broad range of disciplines within the life sciences. Areas covered include molecular biology, cell biology, systems biology, stem cells, developmental biology, genetics and genomics, proteomics, cancer research, immunology, neuroscience, structural biology, microbiology, virology, physiology, biophysics, and computational biology. Paper Digest Team analyze all papers published on CELL in the past years, and presents the 10 most influential papers for each year (based on when the paper became available online). This ranking list is automatically constructed based upon citations from both research papers and granted patents, and will be frequently updated to reflect the most recent changes. To find the most influential papers from other conferences/journals, visit Best Paper Digest page. Note: the most influential papers may or may not include the papers that won the best paper awards. (Last updated on: 2022-02-05)
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TABLE 1: Most Influential CELL Papers (2022-02)
| Year | Rank | Paper | Author(s) |
|---|---|---|---|
| 2021 | 1 | Evidence of Escape of SARS-CoV-2 Variant B.1.351 from Natural and Vaccine-induced Sera IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The race to produce vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) began when the first sequence was published, and this forms the basis for … |
DAMING ZHOU et. al. |
| 2021 | 2 | Adaptive Immunity to SARS-CoV-2 and COVID-19 IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The adaptive immune system is important for control of most viral infections. The three fundamental components of the adaptive immune system are B cells (the source of … |
Alessandro Sette; Shane Crotty; |
| 2021 | 3 | SARS-CoV-2 Variants B.1.351 and P.1 Escape from Neutralizing Antibodies IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The global spread of SARS-CoV-2/COVID-19 is devastating health systems and economies worldwide. Recombinant or vaccine-induced neutralizing antibodies are used to combat the … |
MARKUS HOFFMANN et. al. |
| 2021 | 4 | Integrated Analysis of Multimodal Single-cell Data IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The simultaneous measurement of multiple modalities represents an exciting frontier for single-cell genomics and necessitates computational methods that can define cellular states … |
YUHAN HAO et. al. |
| 2021 | 5 | Circulating SARS-CoV-2 Spike N439K Variants Maintain Fitness While Evading Antibody-mediated Immunity IF:5 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: SARS-CoV-2 can mutate and evade immunity, with consequences for efficacy of emerging vaccines and antibody therapeutics. Here, we demonstrate that the immunodominant SARS-CoV-2 … |
EMMA C THOMSON et. al. |
| 2021 | 6 | Antibody Evasion By The P.1 Strain of SARS-CoV-2 IF:5 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Terminating the SARS-CoV-2 pandemic relies upon pan-global vaccination. Current vaccines elicit neutralizing antibody responses to the virus spike derived from early isolates. … |
WANWISA DEJNIRATTISAI et. al. |
| 2021 | 7 | Reduced Neutralization of SARS-CoV-2 B.1.1.7 Variant By Convalescent and Vaccine Sera IF:5 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: SARS-CoV-2 has caused over 2 million deaths in little over a year. Vaccines are being deployed at scale, aiming to generate responses against the virus spike. The scale of the … |
PIYADA SUPASA et. al. |
| 2021 | 8 | Reduced Neutralization of SARS-CoV-2 B.1.617 By Vaccine and Convalescent Serum IF:5 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has undergone progressive change, with variants conferring advantage rapidly becoming dominant lineages, e.g., … |
CHANG LIU et. al. |
| 2021 | 9 | N-terminal Domain Antigenic Mapping Reveals A Site of Vulnerability for SARS-CoV-2 IF:4 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The SARS-CoV-2 spike (S) glycoprotein contains an immunodominant receptor-binding domain (RBD) targeted by most neutralizing antibodies (Abs) in COVID-19 patient plasma. Little is … |
MATTHEW MCCALLUM et. al. |
| 2020 | 1 | SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked By A Clinically Proven Protease Inhibitor IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The recent emergence of the novel, pathogenic SARS-coronavirus 2 (SARS-CoV-2) in China and its rapid national and international spread pose a global health emergency. Cell entry … |
MARKUS HOFFMANN et. al. |
| 2020 | 2 | Tracking Changes in SARS-CoV-2 Spike: Evidence That D614G Increases Infectivity of The COVID-19 Virus IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: A SARS-CoV-2 variant carrying the Spike protein amino acid change D614G has become the most prevalent form in the global pandemic. Dynamic tracking of variant frequencies revealed … |
BETTE KORBER et. al. |
| 2020 | 3 | Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19 IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Viral pandemics, such as the one caused by SARS-CoV-2, pose an imminent threat to humanity. Because of its recent emergence, there is a paucity of information regarding viral … |
DANIEL BLANCO-MELO et. al. |
| 2020 | 4 | Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Understanding adaptive immunity to SARS-CoV-2 is important for vaccine development, interpreting coronavirus disease 2019 (COVID-19) pathogenesis, and calibration of pandemic … |
ALBA GRIFONI et. al. |
| 2020 | 5 | Structural and Functional Basis of SARS-CoV-2 Entry By Using Human ACE2 IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The recent emergence of a novel coronavirus (SARS-CoV-2) in China has caused significant public health concerns. Recently, ACE2 was reported as an entry receptor for SARS-CoV-2. … |
QIHUI WANG et. al. |
| 2020 | 6 | SARS-CoV-2 Receptor ACE2 Is An Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets Across Tissues IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: There is pressing urgency to understand the pathogenesis of the severe acute respiratory syndrome coronavirus clade 2 (SARS-CoV-2), which causes the disease COVID-19. SARS-CoV-2 … |
CARLY G K ZIEGLER et. al. |
| 2020 | 7 | Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2 IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: We have previously provided the first genetic evidence that angiotensin converting enzyme 2 (ACE2) is the critical receptor for severe acute respiratory syndrome coronavirus … |
VANESSA MONTEIL et. al. |
| 2020 | 8 | The Impact of Mutations in SARS-CoV-2 Spike on Viral Infectivity and Antigenicity IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The spike protein of SARS-CoV-2 has been undergoing mutations and is highly glycosylated. It is critically important to investigate the biological significance of these mutations. … |
QIANQIAN LI et. al. |
| 2020 | 9 | The Architecture of SARS-CoV-2 Transcriptome IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: SARS-CoV-2 is a betacoronavirus responsible for the COVID-19 pandemic. Although the SARS-CoV-2 genome was reported recently, its transcriptomic architecture is unknown. Utilizing … |
DONGWAN KIM et. al. |
| 2020 | 10 | Robust T Cell Immunity in Convalescent Individuals with Asymptomatic Or Mild COVID-19 IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: SARS-CoV-2-specific memory T cells will likely prove critical for long-term immune protection against COVID-19. Here, we systematically mapped the functional and phenotypic … |
TAKUYA SEKINE et. al. |
| 2019 | 1 | Comprehensive Integration Of Single-Cell Data IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Single-cell transcriptomics has transformed our ability to characterize cell states, but deep biological understanding requires more than a taxonomic listing of clusters. As new … |
TIM STUART et. al. |
| 2019 | 2 | Extensive Unexplored Human Microbiome Diversity Revealed By Over 150,000 Genomes from Metagenomes Spanning Age, Geography, and Lifestyle IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The body-wide human microbiome plays a role in health, but its full diversity remains uncharacterized, particularly outside of the gut and in international populations. We … |
EDOARDO PASOLLI et. al. |
| 2019 | 3 | Alzheimer Disease: An Update On Pathobiology And Treatment Strategies IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Alzheimer disease (AD) is a heterogeneous disease with a complex pathobiology. The presence of extracellular β-amyloid deposition as neuritic plaques and intracellular … |
Justin M Long; David M Holtzman; |
| 2019 | 4 | An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Diverse genetic, epigenetic, and developmental programs drive glioblastoma, an incurable and poorly understood tumor, but their precise characterization remains challenging. Here, … |
CYRIL NEFTEL et. al. |
| 2019 | 5 | Cellular Senescence: Defining A Path Forward IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Cellular senescence is a cell state implicated in various physiological processes and a wide spectrum of age-related diseases. Recently, interest in therapeutically targeting … |
VASSILIS GORGOULIS et. al. |
| 2019 | 6 | Predicting Splicing From Primary Sequence With Deep Learning IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The splicing of pre-mRNAs into mature transcripts is remarkable for its precision, but the mechanisms by which the cellular machinery achieves such specificity are incompletely … |
KISHORE JAGANATHAN et. al. |
| 2019 | 7 | A Deep Learning Approach to Antibiotic Discovery IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Due to the rapid emergence of antibiotic-resistant bacteria, there is a growing need to discover new antibiotics. To address this challenge, we trained a deep neural network … |
JONATHAN M STOKES et. al. |
| 2019 | 8 | Unexpected Receptor Functional Mimicry Elucidates Activation Of Coronavirus Fusion IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Recent outbreaks of severe acute respiratory syndrome and Middle East respiratory syndrome, along with the threat of a future coronavirus-mediated pandemic, underscore the … |
ALEXANDRA C WALLS et. al. |
| 2019 | 9 | Single-Cell Multi-omic Integration Compares And Contrasts Features Of Brain Cell Identity IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Defining cell types requires integrating diverse single-cell measurements from multiple experiments and biological contexts. To flexibly model single-cell datasets, we developed … |
JOSHUA D WELCH et. al. |
| 2019 | 10 | The Role Of Non-coding RNAs In Oncology IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: For decades, research into cancer biology focused on the involvement of protein-coding genes. Only recently was it discovered that an entire class of molecules, termed non-coding … |
Frank J Slack; Arul M Chinnaiyan; |
| 2018 | 1 | Molecular Architecture of The Mouse Nervous System IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The mammalian nervous system executes complex behaviors controlled by specialized, precisely positioned, and interacting cell types. Here, we used RNA sequencing of half a million … |
AMIT ZEISEL et. al. |
| 2018 | 2 | Reassessment of Exosome Composition IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The heterogeneity of small extracellular vesicles and presence of non-vesicular extracellular matter have led to debate about contents and functional properties of exosomes. Here, … |
DENNIS K JEPPESEN et. al. |
| 2018 | 3 | Biological Functions Of Autophagy Genes: A Disease Perspective IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The lysosomal degradation pathway of autophagy plays a fundamental role in cellular, tissue, and organismal homeostasis and is mediated by evolutionarily conserved … |
Beth Levine; Guido Kroemer; |
| 2018 | 4 | Innate Lymphoid Cells: 10 Years On IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Innate lymphoid cells (ILCs) are lymphocytes that do not express the type of diversified antigen receptors expressed on T cells and B cells. ILCs are largely tissue-resident cells … |
ERIC VIVIER et. al. |
| 2018 | 5 | Single-Cell Map of Diverse Immune Phenotypes in The Breast Tumor Microenvironment IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Knowledge of immune cell phenotypes in the tumor microenvironment is essential for understanding mechanisms of cancer progression and immunotherapy response. We profiled 45,000 … |
ELHAM AZIZI et. al. |
| 2018 | 6 | Considerations And Challenges In Studying Liquid-Liquid Phase Separation And Biomolecular Condensates IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Evidence is now mounting that liquid-liquid phase separation (LLPS) underlies the formation of membraneless compartments in cells. This realization has motivated major efforts to … |
Simon Alberti; Amy Gladfelter; Tanja Mittag; |
| 2018 | 7 | Molecular Diversity and Specializations Among The Cells of The Adult Mouse Brain IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The mammalian brain is composed of diverse, specialized cell populations. To systematically ascertain and learn from these cellular specializations, we used Drop-seq to profile … |
ARPIAR SAUNDERS et. al. |
| 2018 | 8 | A Molecular Grammar Governing The Driving Forces for Phase Separation of Prion-like RNA Binding Proteins IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Proteins such as FUS phase separate to form liquid-like condensates that can harden into less dynamic structures. However, how these properties emerge from the collective … |
JIE WANG et. al. |
| 2018 | 9 | Recovering Gene Interactions from Single-Cell Data Using Data Diffusion IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Single-cell RNA sequencing technologies suffer from many sources of technical noise, including under-sampling of mRNA molecules, often termed dropout, which can severely obscure … |
DAVID VAN DIJK et. al. |
| 2018 | 10 | Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Treatment of cancer has been revolutionized by immune checkpoint blockade therapies. Despite the high rate of response in advanced melanoma, the majority of patients succumb to … |
MOSHE SADE-FELDMAN et. al. |
| 2017 | 1 | An Expanded View Of Complex Traits: From Polygenic To Omnigenic IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: A central goal of genetics is to understand the links between genetic variation and disease. Intuitively, one might expect disease-causing variants to cluster into key pathways … |
Evan A Boyle; Yang I Li; Jonathan K Pritchard; |
| 2017 | 2 | Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, And Disease IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Ferroptosis is a form of regulated cell death characterized by the iron-dependent accumulation of lipid hydroperoxides to lethal levels. Emerging evidence suggests that … |
BRENT R STOCKWELL et. al. |
| 2017 | 3 | Identifying Medical Diagnoses And Treatable Diseases By Image-Based Deep Learning IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The implementation of clinical-decision support algorithms for medical imaging faces challenges with reliability and interpretability. Here, we establish a diagnostic tool based … |
DANIEL S KERMANY et. al. |
| 2017 | 4 | AKT/PKB Signaling: Navigating The Network IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The Ser and Thr kinase AKT, also known as protein kinase B (PKB), was discovered 25 years ago and has been the focus of tens of thousands of studies in diverse fields of biology … |
Brendan D Manning; Alex Toker; |
| 2017 | 5 | Functional Classification and Experimental Dissection of Long Noncoding RNAs IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Over the last decade, it has been increasingly demonstrated that the genomes of many species are pervasively transcribed, resulting in the production of numerous long noncoding … |
Florian Kopp; Joshua T Mendell; |
| 2017 | 6 | Metazoan MicroRNAs IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: MicroRNAs (miRNAs) are ∼22 nt RNAs that direct posttranscriptional repression of mRNA targets in diverse eukaryotic lineages. In humans and other mammals, these small RNAs help … |
David P Bartel; |
| 2017 | 7 | Emerging Biological Principles Of Metastasis IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Metastases account for the great majority of cancer-associated deaths, yet this complex process remains the least understood aspect of cancer biology. As the body of research … |
Arthur W Lambert; Diwakar R Pattabiraman; Robert A Weinberg; |
| 2017 | 8 | A Next Generation Connectivity Map: L1000 Platform and The First 1,000,000 Profiles IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: We previously piloted the concept of a Connectivity Map (CMap), whereby genes, drugs, and disease states are connected by virtue of common gene-expression signatures. Here, we … |
ARAVIND SUBRAMANIAN et. al. |
| 2017 | 9 | Dynamic RNA Modifications In Gene Expression Regulation IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Over 100 types of chemical modifications have been identified in cellular RNAs. While the 5′ cap modification and the poly(A) tail of eukaryotic mRNA play key roles in regulation, … |
Ian A Roundtree; Molly E Evans; Tao Pan; Chuan He; |
| 2017 | 10 | Oncogenic Signaling Pathways in The Cancer Genome Atlas IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Genetic alterations in signaling pathways that control cell-cycle progression, apoptosis, and cell growth are common hallmarks of cancer, but the extent, mechanisms, and … |
FRANCISCO SANCHEZ-VEGA et. al. |
| 2016 | 1 | From Dietary Fiber To Host Physiology: Short-Chain Fatty Acids As Key Bacterial Metabolites IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: A compelling set of links between the composition of the gut microbiota, the host diet, and host physiology has emerged. Do these links reflect cause-and-effect relationships, and … |
Ara Koh; Filipe De Vadder; Petia Kovatcheva-Datchary; Fredrik Bäckhed; |
| 2016 | 2 | Primary, Adaptive, And Acquired Resistance To Cancer Immunotherapy IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Cancer immunotherapy can induce long lasting responses in patients with metastatic cancers of a wide range of histologies. Broadening the clinical applicability of these … |
Padmanee Sharma; Siwen Hu-Lieskovan; Jennifer A Wargo; Antoni Ribas; |
| 2016 | 3 | MTOR Signaling In Growth, Metabolism, And Disease IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The mechanistic target of rapamycin (mTOR) coordinates eukaryotic cell growth and metabolism with environmental inputs, including nutrients and growth factors. Extensive research … |
Robert A Saxton; David M Sabatini; |
| 2016 | 4 | Abiotic Stress Signaling And Responses In Plants IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: As sessile organisms, plants must cope with abiotic stress such as soil salinity, drought, and extreme temperatures. Core stress-signaling pathways involve protein kinases related … |
Jian-Kang Zhu; |
| 2016 | 5 | Mitochondria And Cancer IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Mitochondria are bioenergetic, biosynthetic, and signaling organelles that are integral in stress sensing to allow for cellular adaptation to the environment. Therefore, it is not … |
Sejal Vyas; Elma Zaganjor; Marcia C Haigis; |
| 2016 | 6 | Modeling Development And Disease With Organoids IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Recent advances in 3D culture technology allow embryonic and adult mammalian stem cells to exhibit their remarkable self-organizing properties, and the resulting organoids reflect … |
Hans Clevers; |
| 2016 | 7 | Clonal Heterogeneity And Tumor Evolution: Past, Present, And The Future IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Intratumor heterogeneity, which fosters tumor evolution, is a key challenge in cancer medicine. Here, we review data and technologies that have revealed intra-tumor heterogeneity … |
Nicholas McGranahan; Charles Swanton; |
| 2016 | 8 | Brain-Region-Specific Organoids Using Mini-bioreactors For Modeling ZIKV Exposure IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Cerebral organoids, three-dimensional cultures that model organogenesis, provide a new platform to investigate human brain development. High cost, variability, and tissue … |
XUYU QIAN et. al. |
| 2016 | 9 | A Dietary Fiber-Deprived Gut Microbiota Degrades The Colonic Mucus Barrier and Enhances Pathogen Susceptibility IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Despite the accepted health benefits of consuming dietary fiber, little is known about the mechanisms by which fiber deprivation impacts the gut microbiota and alters disease … |
MAHESH S DESAI et. al. |
| 2016 | 10 | A Landscape of Pharmacogenomic Interactions in Cancer IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Systematic studies of cancer genomes have provided unprecedented insights into the molecular nature of cancer. Using this information to guide the development and application of … |
FRANCESCO IORIO et. al. |
| 2015 | 1 | Cpf1 Is A Single RNA-guided Endonuclease Of A Class 2 CRISPR-Cas System IF:10 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The microbial adaptive immune system CRISPR mediates defense against foreign genetic elements through two classes of RNA-guided nuclease effectors. Class 1 effectors utilize … |
BERND ZETSCHE et. al. |
| 2015 | 2 | Integrative Clinical Genomics of Advanced Prostate Cancer IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Toward development of a precision medicine framework for metastatic, castration-resistant prostate cancer (mCRPC), we established a multi-institutional clinical sequencing … |
DAN ROBINSON et. al. |
| 2015 | 3 | EMT: 2016 IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The significant parallels between cell plasticity during embryonic development and carcinoma progression have helped us understand the importance of the epithelial-mesenchymal … |
M Angela Nieto; Ruby Yun-Ju Huang; Rebecca A Jackson; Jean Paul Thiery; |
| 2015 | 4 | Communication By Extracellular Vesicles: Where We Are And Where We Need To Go IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: In multicellular organisms, distant cells can exchange information by sending out signals composed of single molecules or, as increasingly exemplified in the literature, via … |
Mercedes Tkach; Clotilde Théry; |
| 2015 | 5 | Immune Checkpoint Targeting In Cancer Therapy: Toward Combination Strategies With Curative Potential IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Research in two fronts has enabled the development of therapies that provide significant benefit to cancer patients. One area stems from a detailed knowledge of mutations that … |
Padmanee Sharma; James P Allison; |
| 2015 | 6 | Metabolic Competition In The Tumor Microenvironment Is A Driver Of Cancer Progression IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Failure of T cells to protect against cancer is thought to result from lack of antigen recognition, chronic activation, and/or suppression by other cells. Using a mouse sarcoma … |
CHIH-HAO CHANG et. al. |
| 2015 | 7 | A Liquid-to-Solid Phase Transition Of The ALS Protein FUS Accelerated By Disease Mutation IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Many proteins contain disordered regions of low-sequence complexity, which cause aging-associated diseases because they are prone to aggregate. Here, we study FUS, a prion-like … |
AVINASH PATEL et. al. |
| 2015 | 8 | Phase Separation By Low Complexity Domains Promotes Stress Granule Assembly and Drives Pathological Fibrillization IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Stress granules are membrane-less organelles composed of RNA-binding proteins (RBPs) and RNA. Functional impairment of stress granules has been implicated in amyotrophic lateral … |
AMANDINE MOLLIEX et. al. |
| 2015 | 9 | N6-methyladenosine Modulates Messenger RNA Translation Efficiency IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: N(6)-methyladenosine (m(6)A) is the most abundant internal modification in mammalian mRNA. This modification is reversible and non-stoichiometric and adds another layer to the … |
XIAO WANG et. al. |
| 2015 | 10 | On The Dependency Of Cellular Protein Levels On MRNA Abundance IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The question of how genomic information is expressed to determine phenotypes is of central importance for basic and translational life science research and has been studied by … |
Yansheng Liu; Andreas Beyer; Ruedi Aebersold; |
| 2014 | 1 | Highly Parallel Genome-wide Expression Profiling Of Individual Cells Using Nanoliter Droplets IF:10 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Cells, the basic units of biological structure and function, vary broadly in type and state. Single-cell genomics can characterize cell identity and function, but limitations of … |
EVAN Z MACOSKO et. al. |
| 2014 | 2 | A 3D Map Of The Human Genome At Kilobase Resolution Reveals Principles Of Chromatin Looping IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: We use in situ Hi-C to probe the 3D architecture of genomes, constructing haploid and diploid maps of nine cell types. The densest, in human lymphoblastoid cells, contains 4.9 … |
SUHAS S P RAO et. al. |
| 2014 | 3 | Development and Applications of CRISPR-Cas9 for Genome Engineering IF:10 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Recent advances in genome engineering technologies based on the CRISPR-associated RNA-guided endonuclease Cas9 are enabling the systematic interrogation of mammalian genome … |
Patrick D Hsu; Eric S Lander; Feng Zhang; |
| 2014 | 4 | Droplet Barcoding For Single-cell Transcriptomics Applied To Embryonic Stem Cells IF:10 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: It has long been the dream of biologists to map gene expression at the single-cell level. With such data one might track heterogeneous cell sub-populations, and infer regulatory … |
ALLON M KLEIN et. al. |
| 2014 | 5 | Human Genetics Shape The Gut Microbiome IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Host genetics and the gut microbiome can both influence metabolic phenotypes. However, whether host genetic variation shapes the gut microbiome and interacts with it to affect … |
JULIA K GOODRICH et. al. |
| 2014 | 6 | Molecular And Genetic Properties Of Tumors Associated With Local Immune Cytolytic Activity IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: How the genomic landscape of a tumor shapes and is shaped by anti-tumor immunity has not been systematically explored. Using large-scale genomic data sets of solid tissue tumor … |
Michael S Rooney; Sachet A Shukla; Catherine J Wu; Gad Getz; Nir Hacohen; |
| 2014 | 7 | Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: While the catalog of mammalian transcripts and their expression levels in different cell types and disease states is rapidly expanding, our understanding of transcript function … |
LUKE A GILBERT et. al. |
| 2014 | 8 | Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA IF:10 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The CRISPR-associated endonuclease Cas9 can be targeted to specific genomic loci by single guide RNAs (sgRNAs). Here, we report the crystal structure of Streptococcus pyogenes … |
HIROSHI NISHIMASU et. al. |
| 2014 | 9 | Mechanisms And Functions Of Inflammasomes IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Recent studies have offered a glimpse into the sophisticated mechanisms by which inflammasomes respond to danger and promote secretion of interleukin (IL)-1β and IL-18. Activation … |
Mohamed Lamkanfi; Vishva M Dixit; |
| 2014 | 10 | Tissue-resident Macrophage Enhancer Landscapes Are Shaped By The Local Microenvironment IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Macrophages are critical for innate immune defense and also control organ homeostasis in a tissue-specific manner. They provide a fitting model to study the impact of ontogeny and … |
YONIT LAVIN et. al. |
| 2013 | 1 | The Somatic Genomic Landscape of Glioblastoma IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: We describe the landscape of somatic genomic alterations based on multidimensional and comprehensive characterization of more than 500 glioblastoma tumors (GBMs). We identify … |
CAMERON W BRENNAN et. al. |
| 2013 | 2 | One-step Generation of Mice Carrying Mutations in Multiple Genes By CRISPR/Cas-mediated Genome Engineering IF:10 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Mice carrying mutations in multiple genes are traditionally generated by sequential recombination in embryonic stem cells and/or time-consuming intercrossing of mice with a single … |
HAOYI WANG et. al. |
| 2013 | 3 | CRISPR-mediated Modular RNA-guided Regulation of Transcription in Eukaryotes IF:10 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The genetic interrogation and reprogramming of cells requires methods for robust and precise targeting of genes for expression or repression. The CRISPR-associated catalytically … |
LUKE A GILBERT et. al. |
| 2013 | 4 | Double Nicking By RNA-guided CRISPR Cas9 for Enhanced Genome Editing Specificity IF:10 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Targeted genome editing technologies have enabled a broad range of research and medical applications. The Cas9 nuclease from the microbial CRISPR-Cas system is targeted to … |
F ANN RAN et. al. |
| 2013 | 5 | Role of The Microbiota in Immunity and Inflammation IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The microbiota plays a fundamental role on the induction, training, and function of the host immune system. In return, the immune system has largely evolved as a means to maintain … |
Yasmine Belkaid; Timothy W Hand; |
| 2013 | 6 | Super-enhancers in The Control of Cell Identity and Disease IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Super-enhancers are large clusters of transcriptional enhancers that drive expression of genes that define cell identity. Improved understanding of the roles that super-enhancers … |
DENES HNISZ et. al. |
| 2013 | 7 | Microbiota Modulate Behavioral and Physiological Abnormalities Associated with Neurodevelopmental Disorders IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Neurodevelopmental disorders, including autism spectrum disorder (ASD), are defined by core behavioral impairments; however, subsets of individuals display a spectrum of … |
ELAINE Y HSIAO et. al. |
| 2013 | 8 | LincRNAs: Genomics, Evolution, and Mechanisms IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Long intervening noncoding RNAs (lincRNAs) are transcribed from thousands of loci in mammalian genomes and might play widespread roles in gene regulation and other cellular … |
Igor Ulitsky; David P Bartel; |
| 2013 | 9 | Regulation of Ferroptotic Cancer Cell Death By GPX4 IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Ferroptosis is a form of nonapoptotic cell death for which key regulators remain unknown. We sought a common mediator for the lethality of 12 ferroptosis-inducing small molecules. … |
WAN SEOK YANG et. al. |
| 2013 | 10 | Microglia Promote Learning-dependent Synapse Formation Through Brain-derived Neurotrophic Factor IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Microglia are the resident macrophages of the CNS, and their functions have been extensively studied in various brain pathologies. The physiological roles of microglia in brain … |
CHRISTOPHER N PARKHURST et. al. |
| 2012 | 1 | The Hallmarks of Aging IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Aging is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death. This deterioration is the primary risk … |
Carlos López-Otín; Maria A Blasco; Linda Partridge; Manuel Serrano; Guido Kroemer; |
| 2012 | 2 | Repurposing CRISPR As An RNA-guided Platform for Sequence-specific Control of Gene Expression IF:10 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Targeted gene regulation on a genome-wide scale is a powerful strategy for interrogating, perturbing, and engineering cellular systems. Here, we develop a method for controlling … |
LEI S QI et. al. |
| 2012 | 3 | Ferroptosis: An Iron-dependent Form of Nonapoptotic Cell Death IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Nonapoptotic forms of cell death may facilitate the selective elimination of some tumor cells or be activated in specific pathological states. The oncogenic RAS-selective lethal … |
SCOTT J DIXON et. al. |
| 2012 | 4 | Master Transcription Factors and Mediator Establish Super-enhancers at Key Cell Identity Genes IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Master transcription factors Oct4, Sox2, and Nanog bind enhancer elements and recruit Mediator to activate much of the gene expression program of pluripotent embryonic stem cells … |
WARREN A WHYTE et. al. |
| 2012 | 5 | Beige Adipocytes Are A Distinct Type of Thermogenic Fat Cell in Mouse and Human IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Brown fat generates heat via the mitochondrial uncoupling protein UCP1, defending against hypothermia and obesity. Recent data suggest that there are two distinct types of brown … |
JUN WU et. al. |
| 2012 | 6 | Cancer Epigenetics: from Mechanism to Therapy IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The epigenetic regulation of DNA-templated processes has been intensely studied over the last 15 years. DNA methylation, histone modification, nucleosome remodeling, and … |
Mark A Dawson; Tony Kouzarides; |
| 2012 | 7 | A Landscape of Driver Mutations in Melanoma IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Despite recent insights into melanoma genetics, systematic surveys for driver mutations are challenged by an abundance of passenger mutations caused by carcinogenic UV light … |
ERAN HODIS et. al. |
| 2012 | 8 | Selective Inhibition of Tumor Oncogenes By Disruption of Super-enhancers IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Chromatin regulators have become attractive targets for cancer therapy, but it is unclear why inhibition of these ubiquitous regulators should have gene-specific effects in tumor … |
JAKOB LOVÉN et. al. |
| 2012 | 9 | Long Noncoding RNAs: Cellular Address Codes in Development and Disease IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: In biology as in real estate, location is a cardinal organizational principle that dictates the accessibility and flow of informational traffic. An essential question in nuclear … |
Pedro J Batista; Howard Y Chang; |
| 2012 | 10 | Three-dimensional Folding and Functional Organization Principles of The Drosophila Genome IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Chromosomes are the physical realization of genetic information and thus form the basis for its readout and propagation. Here we present a high-resolution chromosomal contact map … |
TOM SEXTON et. al. |
| 2011 | 1 | MTOR Signaling in Growth Control and Disease IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The mechanistic target of rapamycin (mTOR) signaling pathway senses and integrates a variety of environmental cues to regulate organismal growth and homeostasis. The pathway … |
Mathieu Laplante; David M Sabatini; |
| 2011 | 2 | A CeRNA Hypothesis: The Rosetta Stone Of A Hidden RNA Language? IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Here, we present a unifying hypothesis about how messenger RNAs, transcribed pseudogenes, and long noncoding RNAs talk to each other using microRNA response elements (MREs) as … |
Leonardo Salmena; Laura Poliseno; Yvonne Tay; Lev Kats; Pier Paolo Pandolfi; |
| 2011 | 3 | Autophagy: Renovation Of Cells And Tissues IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Autophagy is the major intracellular degradation system by which cytoplasmic materials are delivered to and degraded in the lysosome. However, the purpose of autophagy is not the … |
Noboru Mizushima; Masaaki Komatsu; |
| 2011 | 4 | Tumor Metastasis: Molecular Insights And Evolving Paradigms IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Metastases represent the end products of a multistep cell-biological process termed the invasion-metastasis cascade, which involves dissemination of cancer cells to anatomically … |
Scott Valastyan; Robert A Weinberg; |
| 2011 | 5 | The Impact Of The Gut Microbiota On Human Health: An Integrative View IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The human gut harbors diverse microbes that play a fundamental role in the well-being of their host. The constituents of the microbiota–bacteria, viruses, and eukaryotes–have … |
Jose C Clemente; Luke K Ursell; Laura Wegener Parfrey; Rob Knight; |
| 2011 | 6 | BET Bromodomain Inhibition As A Therapeutic Strategy To Target C-Myc IF:10 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: MYC contributes to the pathogenesis of a majority of human cancers, yet strategies to modulate the function of the c-Myc oncoprotein do not exist. Toward this objective, we have … |
JAKE E DELMORE et. al. |
| 2011 | 7 | BET Bromodomain Inhibition As a Therapeutic Strategy to Target C-Myc IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: MYC contributes to the pathogenesis of a majority of human cancers, yet strategies to modulate the function of the c-Myc oncoprotein do not exist. Toward this objective, we have … |
JAKE E. DELMORE et. al. |
| 2011 | 8 | MYC on The Path to Cancer IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The MYC oncogene contributes to the genesis of many human cancers. Recent insights into its expression and function have led to therapeutic opportunities. MYC’s activation by … |
Chi V Dang; |
| 2011 | 9 | Hypoxia-inducible Factors In Physiology And Medicine IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Oxygen homeostasis represents an organizing principle for understanding metazoan evolution, development, physiology, and pathobiology. The hypoxia-inducible factors (HIFs) are … |
Gregg L Semenza; |
| 2011 | 10 | Basic And Therapeutic Aspects Of Angiogenesis IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Blood vessels form extensive networks that nurture all tissues in the body. Abnormal vessel growth and function are hallmarks of cancer and ischemic and inflammatory diseases, and … |
Michael Potente; Holger Gerhardt; Peter Carmeliet; |
| 2010 | 1 | Hallmarks Of Cancer: The Next Generation IF:10 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The hallmarks of cancer comprise six biological capabilities acquired during the multistep development of human tumors. The hallmarks constitute an organizing principle for … |
Douglas Hanahan; Robert A Weinberg; |
| 2010 | 2 | Immunity, Inflammation, and Cancer IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Inflammatory responses play decisive roles at different stages of tumor development, including initiation, promotion, malignant conversion, invasion, and metastasis. Inflammation … |
Sergei I. Grivennikov; Florian R. Greten; Michael Karin; |
| 2010 | 3 | Pattern Recognition Receptors and Inflammation IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Infection of cells by microorganisms activates the inflammatory response. The initial sensing of infection is mediated by innate pattern recognition receptors (PRRs), which … |
Osamu Takeuchi; Shizuo Akira; |
| 2010 | 4 | Cell Signaling By Receptor Tyrosine Kinases IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Recent structural studies of receptor tyrosine kinases (RTKs) have revealed unexpected diversity in the mechanisms of their activation by growth factor ligands. Strategies for … |
Mark A Lemmon; Joseph Schlessinger; |
| 2010 | 5 | Matrix Metalloproteinases: Regulators Of The Tumor Microenvironment IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Extracellular proteolysis mediates tissue homeostasis. In cancer, altered proteolysis leads to unregulated tumor growth, tissue remodeling, inflammation, tissue invasion, and … |
Kai Kessenbrock; Vicki Plaks; Zena Werb; |
| 2010 | 6 | Methods In Mammalian Autophagy Research IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Autophagy has been implicated in many physiological and pathological processes. Accordingly, there is a growing scientific need to accurately identify, quantify, and manipulate … |
Noboru Mizushima; Tamotsu Yoshimori; Beth Levine; |
| 2010 | 7 | Macrophage Diversity Enhances Tumor Progression and Metastasis IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: There is persuasive clinical and experimental evidence that macrophages promote cancer initiation and malignant progression. During tumor initiation, they create an inflammatory … |
Bin-Zhi Qian; Jeffrey W. Pollard; |
| 2010 | 8 | The Inflammasomes IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Inflammasomes are molecular platforms activated upon cellular infection or stress that trigger the maturation of proinflammatory cytokines such as interleukin-1beta to engage … |
Kate Schroder; Jurg Tschopp; |
| 2010 | 9 | Transcriptome-wide Identification of RNA-Binding Protein and MicroRNA Target Sites By PAR-CLIP IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) … |
MARKUS HAFNER et. al. |
| 2010 | 10 | Mechanisms Underlying Inflammation in Neurodegeneration IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Inflammation is associated with many neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, and multiple sclerosis. In this … |
Christopher K. Glass; Kaoru Saijo; Beate Winner; Maria Carolina Marchetto; Fred H. Gage; |