Most Influential NATURE MEDICINE Papers (2022-02)
Nature Medicine is a monthly peer-reviewed medical journal publishing research articles, reviews, news and commentaries in the biomedical area, including both basic research and early-phase clinical research covering all aspects of medicine. Paper Digest Team analyze all papers published on NATURE MEDICINE in the past years, and presents the 10 most influential papers for each year (based on when the paper became available online). This ranking list is automatically constructed based upon citations from both research papers and granted patents, and will be frequently updated to reflect the most recent changes. To find the most influential papers from other conferences/journals, visit Best Paper Digest page. Note: the most influential papers may or may not include the papers that won the best paper awards. (Last updated on: 2022-02-05)
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TABLE 1: Most Influential NATURE MEDICINE Papers (2022-02)
| Year | Rank | Paper | Author(s) |
|---|---|---|---|
| 2021 | 1 | Neutralizing Antibody Levels Are Highly Predictive of Immune Protection from Symptomatic SARS-CoV-2 Infection IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Predictive models of immune protection from COVID-19 are urgently needed to identify correlates of protection to assist in the future deployment of vaccines. To address this, we … |
DAVID S KHOURY et. al. |
| 2021 | 2 | Post-acute COVID-19 Syndrome IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the pathogen responsible for the coronavirus disease 2019 (COVID-19) pandemic, which has resulted in global … |
ANI NALBANDIAN et. al. |
| 2021 | 3 | SARS-CoV-2 501Y.V2 Escapes Neutralization By South African COVID-19 Donor Plasma IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: SARS-CoV-2 501Y.V2 (B.1.351), a novel lineage of coronavirus causing COVID-19, contains substitutions in two immunodominant domains of the spike protein. Here, we show that … |
CONSTANTINOS KURT WIBMER et. al. |
| 2021 | 4 | Resistance of SARS-CoV-2 Variants to Neutralization By Monoclonal and Serum-derived Polyclonal Antibodies IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the global COVID-19 pandemic. Rapidly spreading SARS-CoV-2 variants may jeopardize newly introduced … |
RITA E CHEN et. al. |
| 2021 | 5 | Attributes and Predictors of Long COVID IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Reports of long-lasting coronavirus disease 2019 (COVID-19) symptoms, the so-called ‘long COVID’, are rising but little is known about prevalence, risk factors or whether it is … |
CAROLE H SUDRE et. al. |
| 2021 | 6 | Neutralization of SARS-CoV-2 Spike 69/70 Deletion, E484K and N501Y Variants By BNT162b2 Vaccine-elicited Sera IF:5 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: We engineered three severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viruses containing key spike mutations from the newly emerged United Kingdom (UK) and South … |
XUPING XIE et. al. |
| 2021 | 7 | Sensitivity of Infectious SARS-CoV-2 B.1.1.7 and B.1.351 Variants to Neutralizing Antibodies IF:5 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) B.1.1.7 and B.1.351 variants were first identified in the United Kingdom and South Africa, respectively, and have … |
DELPHINE PLANAS et. al. |
| 2021 | 8 | Antibody Responses to The BNT162b2 MRNA Vaccine in Individuals Previously Infected with SARS-CoV-2 IF:5 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: In a cohort of BNT162b2 (Pfizer-BioNTech) mRNA vaccine recipients (n = 1,090), we observed that spike-specific IgG antibody levels and ACE2 antibody binding inhibition responses … |
JOSEPH E EBINGER et. al. |
| 2021 | 9 | Looking Beyond COVID-19 Vaccine Phase 3 Trials IF:5 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: After the recent announcement of COVID-19 vaccine efficacy in clinical trials by several manufacturers for protection against severe disease, a comprehensive post-efficacy … |
Jerome H Kim; Florian Marks; John D Clemens; |
| 2021 | 10 | Initial Report of Decreased SARS-CoV-2 Viral Load After Inoculation with The BNT162b2 Vaccine IF:5 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Beyond their substantial protection of individual vaccinees, coronavirus disease 2019 (COVID-19) vaccines might reduce viral load in breakthrough infection and thereby further … |
MATAN LEVINE-TIEFENBRUN et. al. |
| 2020 | 1 | The Proximal Origin of SARS-CoV-2 IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details |
Kristian G Andersen; Andrew Rambaut; W Ian Lipkin; Edward C Holmes; Robert F Garry; |
| 2020 | 2 | Temporal Dynamics in Viral Shedding and Transmissibility of COVID-19 IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: We report temporal patterns of viral shedding in 94 patients with laboratory-confirmed COVID-19 and modeled COVID-19 infectiousness profiles from a separate sample of 77 … |
XI HE et. al. |
| 2020 | 3 | Antibody Responses to SARS-CoV-2 in Patients with COVID-19 IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: We report acute antibody responses to SARS-CoV-2 in 285 patients with COVID-19. Within 19 days after symptom onset, 100% of patients tested positive for antiviral immunoglobulin-G … |
QUAN-XIN LONG et. al. |
| 2020 | 4 | Clinical and Immunological Assessment of Asymptomatic SARS-CoV-2 Infections IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The clinical features and immune responses of asymptomatic individuals infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have not been well described. We … |
QUAN-XIN LONG et. al. |
| 2020 | 5 | SARS-CoV-2 Entry Factors Are Highly Expressed in Nasal Epithelial Cells Together with Innate Immune Genes IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: We investigated SARS-CoV-2 potential tropism by surveying expression of viral entry-associated genes in single-cell RNA-sequencing data from multiple tissues from healthy human … |
WARADON SUNGNAK et. al. |
| 2020 | 6 | Respiratory Virus Shedding in Exhaled Breath and Efficacy of Face Masks IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: We identified seasonal human coronaviruses, influenza viruses and rhinoviruses in exhaled breath and coughs of children and adults with acute respiratory illness. Surgical face … |
NANCY H L LEUNG et. al. |
| 2020 | 7 | Single-cell Landscape of Bronchoalveolar Immune Cells in Patients with COVID-19 IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Respiratory immune characteristics associated with Coronavirus Disease 2019 (COVID-19) severity are currently unclear. We characterized bronchoalveolar lavage fluid immune cells … |
MINGFENG LIAO et. al. |
| 2020 | 8 | Extrapulmonary Manifestations of COVID-19 IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Although COVID-19 is most well known for causing substantial respiratory pathology, it can also result in several extrapulmonary manifestations. These conditions include … |
AAKRITI GUPTA et. al. |
| 2020 | 9 | Modelling The COVID-19 Epidemic and Implementation of Population-wide Interventions in Italy IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: In Italy, 128,948 confirmed cases and 15,887 deaths of people who tested positive for SARS-CoV-2 were registered as of 5 April 2020. Ending the global SARS-CoV-2 pandemic requires … |
GIULIA GIORDANO et. al. |
| 2020 | 10 | Characteristics of Pediatric SARS-CoV-2 Infection and Potential Evidence for Persistent Fecal Viral Shedding IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: We report epidemiological and clinical investigations on ten pediatric SARS-CoV-2 infection cases confirmed by real-time reverse transcription PCR assay of SARS-CoV-2 RNA. … |
YI XU et. al. |
| 2019 | 1 | High-performance Medicine: The Convergence Of Human And Artificial Intelligence IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The use of artificial intelligence, and the deep-learning subtype in particular, has been enabled by the use of labeled big data, along with markedly enhanced computing power and … |
Eric J Topol; |
| 2019 | 2 | A Guide To Deep Learning In Healthcare IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Here we present deep-learning techniques for healthcare, centering our discussion on deep learning in computer vision, natural language processing, reinforcement learning, and … |
ANDRE ESTEVA et. al. |
| 2019 | 3 | Cardiologist-level Arrhythmia Detection And Classification In Ambulatory Electrocardiograms Using A Deep Neural Network IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Computerized electrocardiogram (ECG) interpretation plays a critical role in the clinical ECG workflow . Widely available digital ECG data and the algorithmic paradigm of deep … |
AWNI Y HANNUN et. al. |
| 2019 | 4 | Chronic Inflammation in The Etiology of Disease Across The Life Span IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Although intermittent increases in inflammation are critical for survival during physical injury and infection, recent research has revealed that certain social, environmental and … |
DAVID FURMAN et. al. |
| 2019 | 5 | End-to-end Lung Cancer Screening With Three-dimensional Deep Learning On Low-dose Chest Computed Tomography IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: With an estimated 160,000 deaths in 2018, lung cancer is the most common cause of cancer death in the United States . Lung cancer screening using low-dose computed tomography has … |
DIEGO ARDILA et. al. |
| 2019 | 6 | Clinical-grade Computational Pathology Using Weakly Supervised Deep Learning On Whole Slide Images IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The development of decision support systems for pathology and their deployment in clinical practice have been hindered by the need for large manually annotated datasets. To … |
GABRIELE CAMPANELLA et. al. |
| 2019 | 7 | Supplementation with Akkermansia Muciniphila in Overweight and Obese Human Volunteers: A Proof-of-concept Exploratory Study IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Metabolic syndrome is characterized by a constellation of comorbidities that predispose individuals to an increased risk of developing cardiovascular pathologies as well as type 2 … |
CLARA DEPOMMIER et. al. |
| 2019 | 8 | Blood-brain Barrier Breakdown Is An Early Biomarker of Human Cognitive Dysfunction IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Vascular contributions to cognitive impairment are increasingly recognized as shown by neuropathological , neuroimaging , and cerebrospinal fluid biomarker studies. Moreover, … |
DANIEL A NATION et. al. |
| 2019 | 9 | The Practical Implementation Of Artificial Intelligence Technologies In Medicine IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The development of artificial intelligence (AI)-based technologies in medicine is advancing rapidly, but real-world clinical implementation has not yet become a reality. Here we … |
JIANXING HE et. al. |
| 2019 | 10 | Engineered Bacteriophages for Treatment of A Patient with A Disseminated Drug Resistant Mycobacterium Abscessus IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: A 15-year-old patient with cystic fibrosis with a disseminated Mycobacterium abscessus infection was treated with a three-phage cocktail following bilateral lung transplantation. … |
REBEKAH M DEDRICK et. al. |
| 2018 | 1 | Understanding The Tumor Immune Microenvironment (TIME) for Effective Therapy IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The clinical successes in immunotherapy have been both astounding and at the same time unsatisfactory. Countless patients with varied tumor types have seen pronounced clinical … |
MIKHAIL BINNEWIES et. al. |
| 2018 | 2 | Clinically Applicable Deep Learning for Diagnosis and Referral in Retinal Disease IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The volume and complexity of diagnostic imaging is increasing at a pace faster than the availability of human expertise to interpret it. Artificial intelligence has shown great … |
JEFFREY DE FAUW et. al. |
| 2018 | 3 | Mechanisms Of NAFLD Development And Therapeutic Strategies IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: There has been a rise in the prevalence of nonalcoholic fatty liver disease (NAFLD), paralleling a worldwide increase in diabetes and metabolic syndrome. NAFLD, a continuum of … |
Scott L Friedman; Brent A Neuschwander-Tetri; Mary Rinella; Arun J Sanyal; |
| 2018 | 4 | Senolytics Improve Physical Function and Increase Lifespan in Old Age IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Physical function declines in old age, portending disability, increased health expenditures, and mortality. Cellular senescence, leading to tissue dysfunction, may contribute to … |
MING XU et. al. |
| 2018 | 5 | Molecular Subtypes of Diffuse Large B Cell Lymphoma Are Associated with Distinct Pathogenic Mechanisms and Outcomes IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Diffuse large B cell lymphoma (DLBCL), the most common lymphoid malignancy in adults, is a clinically and genetically heterogeneous disease that is further classified into … |
BJOERN CHAPUY et. al. |
| 2018 | 6 | Signatures Of T Cell Dysfunction And Exclusion Predict Cancer Immunotherapy Response IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Cancer treatment by immune checkpoint blockade (ICB) can bring long-lasting clinical benefits, but only a fraction of patients respond to treatment. To predict ICB response, we … |
PENG JIANG et. al. |
| 2018 | 7 | Determinants of Response and Resistance to CD19 Chimeric Antigen Receptor (CAR) T Cell Therapy of Chronic Lymphocytic Leukemia IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Tolerance to self-antigens prevents the elimination of cancer by the immune system . We used synthetic chimeric antigen receptors (CARs) to overcome immunological tolerance and … |
JOSEPH A FRAIETTA et. al. |
| 2018 | 8 | Monocyte-derived IL-1 And IL-6 Are Differentially Required For Cytokine-release Syndrome And Neurotoxicity Due To CAR T Cells IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: In the clinic, chimeric antigen receptor-modified T (CAR T) cell therapy is frequently associated with life-threatening cytokine-release syndrome (CRS) and neurotoxicity. … |
MARGHERITA NORELLI et. al. |
| 2018 | 9 | Phenotype Molding Of Stromal Cells In The Lung Tumor Microenvironment IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Cancer cells are embedded in the tumor microenvironment (TME), a complex ecosystem of stromal cells. Here, we present a 52,698-cell catalog of the TME transcriptome in human lung … |
DIETHER LAMBRECHTS et. al. |
| 2018 | 10 | Blood-based Tumor Mutational Burden As A Predictor Of Clinical Benefit In Non-small-cell Lung Cancer Patients Treated With Atezolizumab IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Although programmed death-ligand 1-programmed death 1 (PD-L1-PD-1) inhibitors are broadly efficacious, improved outcomes have been observed in patients with high PD-L1 expression … |
DAVID R GANDARA et. al. |
| 2017 | 1 | Mutational Landscape Of Metastatic Cancer Revealed From Prospective Clinical Sequencing Of 10,000 Patients IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Tumor molecular profiling is a fundamental component of precision oncology, enabling the identification of genomic alterations in genes and pathways that can be targeted … |
AHMET ZEHIR et. al. |
| 2017 | 2 | Cancer Stem Cells Revisited IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The cancer stem cell (CSC) concept was proposed four decades ago, and states that tumor growth, analogous to the renewal of healthy tissues, is fueled by small numbers of … |
Eduard Batlle; Hans Clevers; |
| 2017 | 3 | Metformin Alters The Gut Microbiome Of Individuals With Treatment-naive Type 2 Diabetes, Contributing To The Therapeutic Effects Of The Drug IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Metformin is widely used in the treatment of type 2 diabetes (T2D), but its mechanism of action is poorly defined. Recent evidence implicates the gut microbiota as a site of … |
HAO WU et. al. |
| 2017 | 4 | CD22-targeted CAR T Cells Induce Remission In B-ALL That Is Naive Or Resistant To CD19-targeted CAR Immunotherapy IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Chimeric antigen receptor (CAR) T cells targeting CD19 mediate potent effects in relapsed and/or refractory pre-B cell acute lymphoblastic leukemia (B-ALL), but antigen loss is a … |
TERRY J FRY et. al. |
| 2017 | 5 | CD22-CAR T Cells Induce Remissions in CD19-CAR Naïve and Resistant B-ALL IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Chimeric antigen receptor (CAR) T-cells targeting CD19 mediate potent effects in relapsed/refractory pre-B cell acute lymphoblastic leukemia (B-ALL) but antigen loss is a frequent … |
TERRY J. FRY et. al. |
| 2017 | 6 | Local Clearance Of Senescent Cells Attenuates The Development Of Post-traumatic Osteoarthritis And Creates A Pro-regenerative Environment IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Senescent cells (SnCs) accumulate in many vertebrate tissues with age and contribute to age-related pathologies, presumably through their secretion of factors contributing to the … |
OK HEE JEON et. al. |
| 2017 | 7 | Gut Microbiome And Serum Metabolome Alterations In Obesity And After Weight-loss Intervention IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Emerging evidence has linked the gut microbiome to human obesity. We performed a metagenome-wide association study and serum metabolomics profiling in a cohort of lean and obese, … |
RUIXIN LIU et. al. |
| 2017 | 8 | Human Primary Liver Cancer -derived Organoid Cultures for Disease Modelling and Drug Screening IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Human liver cancer research currently lacks in vitro models that can faithfully recapitulate the pathophysiology of the original tumor. We recently described a novel, … |
LAURA BROUTIER et. al. |
| 2017 | 9 | Maturation Of The Infant Microbiome Community Structure And Function Across Multiple Body Sites And In Relation To Mode Of Delivery IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Human microbial communities are characterized by their taxonomic, metagenomic and metabolic diversity, which varies by distinct body sites and influences human physiology. … |
DERRICK M CHU et. al. |
| 2017 | 10 | HRDetect Is A Predictor Of BRCA1 And BRCA2 Deficiency Based On Mutational Signatures IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Approximately 1-5% of breast cancers are attributed to inherited mutations in BRCA1 or BRCA2 and are selectively sensitive to poly(ADP-ribose) polymerase (PARP) inhibitors. In … |
HELEN DAVIES et. al. |
| 2016 | 1 | Resting-state Connectivity Biomarkers Define Neurophysiological Subtypes Of Depression IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Biomarkers have transformed modern medicine but remain largely elusive in psychiatry, partly because there is a weak correspondence between diagnostic labels and their … |
ANDREW T DRYSDALE et. al. |
| 2016 | 2 | Divergent Clonal Evolution of Castration Resistant Neuroendocrine Prostate Cancer IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: An increasingly recognized resistance mechanism to androgen receptor (AR)-directed therapy in prostate cancer involves epithelial plasticity, in which tumor cells demonstrate low … |
HIMISHA BELTRAN et. al. |
| 2016 | 3 | A Purified Membrane Protein From Akkermansia Muciniphila Or The Pasteurized Bacterium Improves Metabolism In Obese And Diabetic Mice IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Obesity and type 2 diabetes are associated with low-grade inflammation and specific changes in gut microbiota composition. We previously demonstrated that administration of … |
HUBERT PLOVIER et. al. |
| 2016 | 4 | Current Understanding Of The Human Microbiome IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Our understanding of the link between the human microbiome and disease, including obesity, inflammatory bowel disease, arthritis and autism, is rapidly expanding. Improvements in … |
JACK A GILBERT et. al. |
| 2016 | 5 | Microglia Emerge As Central Players In Brain Disease IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: There has been an explosion of new findings recently giving us insights into the involvement of microglia in central nervous system (CNS) disorders. A host of new molecular tools … |
Michael W Salter; Beth Stevens; |
| 2016 | 6 | Neutrophil Extracellular Traps Enriched In Oxidized Mitochondrial DNA Are Interferogenic And Contribute To Lupus-like Disease IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Neutrophil extracellular traps (NETs) are implicated in autoimmunity, but how they are generated and their roles in sterile inflammation remain unclear. Ribonucleoprotein immune … |
CHRISTIAN LOOD et. al. |
| 2016 | 7 | CARD9 Impacts Colitis By Altering Gut Microbiota Metabolism Of Tryptophan Into Aryl Hydrocarbon Receptor Ligands IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Complex interactions between the host and the gut microbiota govern intestinal homeostasis but remain poorly understood. Here we reveal a relationship between gut microbiota and … |
BRUNO LAMAS et. al. |
| 2016 | 8 | Signals From The Gut Microbiota To Distant Organs In Physiology And Disease IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The ecosystem of the human gut consists of trillions of bacteria forming a bioreactor that is fueled by dietary macronutrients to produce bioactive compounds. These … |
Bjoern O Schroeder; Fredrik Bäckhed; |
| 2016 | 9 | Partial Restoration Of The Microbiota Of Cesarean-born Infants Via Vaginal Microbial Transfer IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Exposure of newborns to the maternal vaginal microbiota is interrupted with cesarean birthing. Babies delivered by cesarean section (C-section) acquire a microbiota that differs … |
MARIA G DOMINGUEZ-BELLO et. al. |
| 2016 | 10 | Tumor Cells Can Follow Distinct Evolutionary Paths To Become Resistant To Epidermal Growth Factor Receptor Inhibition IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Although mechanisms of acquired resistance of epidermal growth factor receptor (EGFR)-mutant non-small-cell lung cancers to EGFR inhibitors have been identified, little is known … |
AARON N HATA et. al. |
| 2015 | 1 | The Consensus Molecular Subtypes Of Colorectal Cancer IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Colorectal cancer (CRC) is a frequently lethal disease with heterogeneous outcomes and drug responses. To resolve inconsistencies among the reported gene expression-based CRC … |
JUSTIN GUINNEY et. al. |
| 2015 | 2 | Inflammasomes: Mechanism Of Action, Role In Disease, And Therapeutics IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The inflammasomes are innate immune system receptors and sensors that regulate the activation of caspase-1 and induce inflammation in response to infectious microbes and molecules … |
Haitao Guo; Justin B Callaway; Jenny P-Y Ting; |
| 2015 | 3 | The Emerging Role Of LncRNAs In Cancer IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: It is increasingly evident that many of the genomic mutations in cancer reside inside regions that do not encode proteins. However, these regions are often transcribed into long … |
Maite Huarte; |
| 2015 | 4 | The Prognostic Landscape Of Genes And Infiltrating Immune Cells Across Human Cancers IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Molecular profiles of tumors and tumor-associated cells hold great promise as biomarkers of clinical outcomes. However, existing data sets are fragmented and difficult to analyze … |
ANDREW J GENTLES et. al. |
| 2015 | 5 | A Small-molecule Inhibitor of The NLRP3 Inflammasome for The Treatment of Inflammatory Diseases IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The NOD-like receptor (NLR) family, pyrin domain-containing protein 3 (NLRP3) inflammasome is a component of the inflammatory process, and its aberrant activation is pathogenic in … |
REBECCA C COLL et. al. |
| 2015 | 6 | Molecular Analysis Of Gastric Cancer Identifies Subtypes Associated With Distinct Clinical Outcomes IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Gastric cancer, a leading cause of cancer-related deaths, is a heterogeneous disease. We aim to establish clinically relevant molecular subtypes that would encompass this … |
RAZVAN CRISTESCU et. al. |
| 2015 | 7 | Cellular Senescence In Aging And Age-related Disease: From Mechanisms To Therapy IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Cellular senescence, a process that imposes permanent proliferative arrest on cells in response to various stressors, has emerged as a potentially important contributor to aging … |
Bennett G Childs; Matej Durik; Darren J Baker; Jan M van Deursen; |
| 2015 | 8 | Therapeutic Genome Editing: Prospects And Challenges IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Recent advances in the development of genome editing technologies based on programmable nucleases have substantially improved our ability to make precise changes in the genomes of … |
David Benjamin Turitz Cox; Randall Jeffrey Platt; Feng Zhang; |
| 2015 | 9 | Clearance Of Senescent Cells By ABT263 Rejuvenates Aged Hematopoietic Stem Cells In Mice IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Senescent cells (SCs) accumulate with age and after genotoxic stress, such as total-body irradiation (TBI). Clearance of SCs in a progeroid mouse model using a transgenic approach … |
JIANHUI CHANG et. al. |
| 2015 | 10 | The Oral And Gut Microbiomes Are Perturbed In Rheumatoid Arthritis And Partly Normalized After Treatment IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: We carried out metagenomic shotgun sequencing and a metagenome-wide association study (MGWAS) of fecal, dental and salivary samples from a cohort of individuals with rheumatoid … |
XUAN ZHANG et. al. |
| 2014 | 1 | Gut Microbiota Metabolism of Dietary Fiber Influences Allergic Airway Disease and Hematopoiesis IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Metabolites from intestinal microbiota are key determinants of host-microbe mutualism and, consequently, the health or disease of the intestinal tract. However, whether such … |
AURÉLIEN TROMPETTE et. al. |
| 2014 | 2 | An Ultrasensitive Method for Quantitating Circulating Tumor DNA with Broad Patient Coverage IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Circulating tumor DNA (ctDNA) is a promising biomarker for noninvasive assessment of cancer burden, but existing ctDNA detection methods have insufficient sensitivity or patient … |
AARON M NEWMAN et. al. |
| 2014 | 3 | Age-related Cancer Mutations Associated with Clonal Hematopoietic Expansion IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Several genetic alterations characteristic of leukemia and lymphoma have been detected in the blood of individuals without apparent hematological malignancies. The Cancer Genome … |
MINGCHAO XIE et. al. |
| 2014 | 4 | Plasma Phospholipids Identify Antecedent Memory Impairment in Older Adults IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Alzheimer’s disease causes a progressive dementia that currently affects over 35 million individuals worldwide and is expected to affect 115 million by 2050 (ref. 1). There are no … |
MARK MAPSTONE et. al. |
| 2014 | 5 | Young Blood Reverses Age-related Impairments in Cognitive Function and Synaptic Plasticity in Mice IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: As human lifespan increases, a greater fraction of the population is suffering from age-related cognitive impairments, making it important to elucidate a means to combat the … |
SAUL A VILLEDA et. al. |
| 2014 | 6 | Defective Fatty Acid Oxidation In Renal Tubular Epithelial Cells Has A Key Role In Kidney Fibrosis Development IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Renal fibrosis is the histological manifestation of a progressive, usually irreversible process causing chronic and end-stage kidney disease. We performed genome-wide … |
HYUN MI KANG et. al. |
| 2014 | 7 | Multiplexed Ion Beam Imaging of Human Breast Tumors IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Immunohistochemistry (IHC) is a tool for visualizing protein expression that is employed as part of the diagnostic workup for the majority of solid tissue malignancies. Existing … |
MICHAEL ANGELO et. al. |
| 2014 | 8 | Anchored Multiplex PCR For Targeted Next-generation Sequencing IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: We describe a rapid target enrichment method for next-generation sequencing, termed anchored multiplex PCR (AMP), that is compatible with low nucleic acid input from … |
ZONGLI ZHENG et. al. |
| 2014 | 9 | Alopecia Areata Is Driven By Cytotoxic T Lymphocytes and Is Reversed By JAK Inhibition IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Alopecia areata (AA) is a common autoimmune disease resulting from damage of the hair follicle by T cells. The immune pathways required for autoreactive T cell activation in AA … |
LUZHOU XING et. al. |
| 2014 | 10 | Autosomal-dominant Immune Dysregulation Syndrome in Humans with CTLA4 Mutations IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The protein cytotoxic T lymphocyte antigen-4 (CTLA-4) is an essential negative regulator of immune responses, and its loss causes fatal autoimmunity in mice. We studied a large … |
DESIRÉE SCHUBERT et. al. |
| 2013 | 1 | Microenvironmental Regulation of Tumor Progression and Metastasis IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Cancers develop in complex tissue environments, which they depend on for sustained growth, invasion and metastasis. Unlike tumor cells, stromal cell types within the tumor … |
Daniela F Quail; Johanna A Joyce; |
| 2013 | 2 | Intestinal Microbiota Metabolism of L-carnitine, A Nutrient in Red Meat, Promotes Atherosclerosis IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Intestinal microbiota metabolism of choline and phosphatidylcholine produces trimethylamine (TMA), which is further metabolized to a proatherogenic species, trimethylamine-N-oxide … |
ROBERT A KOETH et. al. |
| 2013 | 3 | ABT-199, A Potent and Selective BCL-2 Inhibitor, Achieves Antitumor Activity While Sparing Platelets IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Proteins in the B cell CLL/lymphoma 2 (BCL-2) family are key regulators of the apoptotic process. This family comprises proapoptotic and prosurvival proteins, and shifting the … |
ANDREW J SOUERS et. al. |
| 2013 | 4 | Brown and Beige Fat: Development, Function and Therapeutic Potential IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Adipose tissue, best known for its role in fat storage, can also suppress weight gain and metabolic disease through the action of specialized, heat-producing adipocytes. Brown … |
Matthew Harms; Patrick Seale; |
| 2013 | 5 | WNT Signaling in Bone Homeostasis and Disease: from Human Mutations to Treatments IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Low bone mass and strength lead to fragility fractures, for example, in elderly individuals affected by osteoporosis or children with osteogenesis imperfecta. A decade ago, rare … |
Roland Baron; Michaela Kneissel; |
| 2013 | 6 | The Role of Autophagy in Neurodegenerative Disease IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Autophagy is a lysosomal degradative process used to recycle obsolete cellular constituents and eliminate damaged organelles and protein aggregates. These substrates reach … |
Ralph A Nixon; |
| 2013 | 7 | CSF-1R Inhibition Alters Macrophage Polarization and Blocks Glioma Progression IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Glioblastoma multiforme (GBM) comprises several molecular subtypes, including proneural GBM. Most therapeutic approaches targeting glioma cells have failed. An alternative … |
STEPHANIE M PYONTECK et. al. |
| 2013 | 8 | Development, Maintenance and Disruption of The Blood-brain Barrier IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The interface between the blood circulation and the neural tissue features unique characteristics that are encompassed by the term ‘blood-brain barrier’ (BBB). The main functions … |
Birgit Obermeier; Richard Daneman; Richard M Ransohoff; |
| 2013 | 9 | The Meaning, The Sense and The Significance: Translating The Science of Mesenchymal Stem Cells Into Medicine IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Mesenchymal stem cells (MSCs) are the focus of intensive efforts worldwide directed not only at elucidating their nature and unique properties but also developing cell-based … |
PAOLO BIANCO et. al. |
| 2013 | 10 | Mining Exomic Sequencing Data to Identify Mutated Antigens Recognized By Adoptively Transferred Tumor-reactive T Cells IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Substantial regressions of metastatic lesions have been observed in up to 70% of patients with melanoma who received adoptively transferred autologous tumor-infiltrating … |
PAUL F ROBBINS et. al. |
| 2012 | 1 | Melanoma Exosomes Educate Bone Marrow Progenitor Cells Toward A Pro-metastatic Phenotype Through MET IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Tumor-derived exosomes are emerging mediators of tumorigenesis. We explored the function of melanoma-derived exosomes in the formation of primary tumors and metastases in mice and … |
HÉCTOR PEINADO et. al. |
| 2012 | 2 | Mechanisms of Fibrosis: Therapeutic Translation for Fibrotic Disease IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Fibrosis is a pathological feature of most chronic inflammatory diseases. Fibrosis, or scarring, is defined by the accumulation of excess extracellular matrix components. If … |
Thomas A Wynn; Thirumalai R Ramalingam; |
| 2012 | 3 | Asthma Phenotypes: The Evolution from Clinical to Molecular Approaches IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Although asthma has been considered as a single disease for years, recent studies have increasingly focused on its heterogeneity. The characterization of this heterogeneity has … |
Sally E Wenzel; |
| 2012 | 4 | The Cellular and Signaling Networks Linking The Immune System and Metabolism in Disease IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: It is now recognized that obesity is driving the type 2 diabetes epidemic in Western countries. Obesity-associated chronic tissue inflammation is a key contributing factor to type … |
Olivia Osborn; Jerrold M Olefsky; |
| 2012 | 5 | Identification of The Molecular Basis of Doxorubicin-induced Cardiotoxicity IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Doxorubicin is believed to cause dose-dependent cardiotoxicity through redox cycling and the generation of reactive oxygen species (ROS). Here we show that cardiomyocyte-specific … |
SUI ZHANG et. al. |
| 2012 | 6 | IgE and Mast Cells in Allergic Disease IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Immunoglobulin E (IgE) antibodies and mast cells have been so convincingly linked to the pathophysiology of anaphylaxis and other acute allergic reactions that it can be difficult … |
Stephen J Galli; Mindy Tsai; |
| 2012 | 7 | RET, ROS1 and ALK Fusions in Lung Cancer IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Through an integrated molecular- and histopathology-based screening system, we performed a screening for fusions of anaplastic lymphoma kinase (ALK) and c-ros oncogene 1, receptor … |
KENGO TAKEUCHI et. al. |
| 2012 | 8 | In Vivo Photodynamic Therapy Using Upconversion Nanoparticles As Remote-controlled Nanotransducers IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Conventional photodynamic therapy (PDT) is limited by the penetration depth of visible light needed for its activation. Here we used mesoporous-silica-coated upconversion … |
NIAGARA MUHAMMAD IDRIS et. al. |
| 2012 | 9 | Multipeptide Immune Response to Cancer Vaccine IMA901 After Single-dose Cyclophosphamide Associates with Longer Patient Survival IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: IMA901 is the first therapeutic vaccine for renal cell cancer (RCC) consisting of multiple tumor-associated peptides (TUMAPs) confirmed to be naturally presented in human cancer … |
STEFFEN WALTER et. al. |
| 2012 | 10 | Preexisting Influenza-specific CD4+ T Cells Correlate with Disease Protection Against Influenza Challenge in Humans IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Protective immunity against influenza virus infection is mediated by neutralizing antibodies, but the precise role of T cells in human influenza immunity is uncertain. We … |
TOM M WILKINSON et. al. |
| 2011 | 1 | Metabolite Profiles And The Risk Of Developing Diabetes IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Emerging technologies allow the high-throughput profiling of metabolic status from a blood specimen (metabolomics). We investigated whether metabolite profiles could predict the … |
THOMAS J WANG et. al. |
| 2011 | 2 | The Immunology Of Stroke: From Mechanisms To Translation IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Immunity and inflammation are key elements of the pathobiology of stroke, a devastating illness second only to cardiac ischemia as a cause of death worldwide. The immune system … |
Costantino Iadecola; Josef Anrather; |
| 2011 | 3 | The Cancer Stem Cell: Premises, Promises And Challenges IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Over the last decade, the notion that tumors are maintained by their own stem cells, the so-called cancer stem cells, has created great excitement in the research community. This … |
Hans Clevers; |
| 2011 | 4 | Atherosclerosis: Current Pathogenesis and Therapeutic Options IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Coronary artery disease (CAD) arising from atherosclerosis is a leading cause of death and morbidity worldwide. The underlying pathogenesis involves an imbalanced lipid metabolism … |
Christian Weber; Heidi Noels; |
| 2011 | 5 | Tumor Angiogenesis: Molecular Pathways and Therapeutic Targets IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: As angiogenesis is essential for tumor growth and metastasis, controlling tumor-associated angiogenesis is a promising tactic in limiting cancer progression. The tumor … |
Sara M Weis; David A Cheresh; |
| 2011 | 6 | Adipocytes Promote Ovarian Cancer Metastasis and Provide Energy for Rapid Tumor Growth IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Intra-abdominal tumors, such as ovarian cancer, have a clear predilection for metastasis to the omentum, an organ primarily composed of adipocytes. Currently, it is unclear why … |
KRISTIN M NIEMAN et. al. |
| 2011 | 7 | A Human Memory T-cell Subset with Stem Cell-like Properties IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Immunological memory is thought to depend on a stem cell–like, self-renewing population of lymphocytes capable of differentiating into effector cells in response to antigen … |
LUCA GATTINONI et. al. |
| 2011 | 8 | Evidence For Osteocyte Regulation Of Bone Homeostasis Through RANKL Expression IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Osteocytes embedded in bone have been postulated to orchestrate bone homeostasis by regulating both bone-forming osteoblasts and bone-resorbing osteoclasts. We find here that … |
TOMOKI NAKASHIMA et. al. |
| 2011 | 9 | The MicroRNA MiR-34a Inhibits Prostate Cancer Stem Cells And Metastasis By Directly Repressing CD44 IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Cancer stem cells (CSCs), or tumor-initiating cells, are involved in tumor progression and metastasis. MicroRNAs (miRNAs) regulate both normal stem cells and CSCs, and … |
CAN LIU et. al. |
| 2011 | 10 | Identification of MiR-34a As A Potent Inhibitor of Prostate Cancer Progenitor Cells and Metastasis By Directly Repressing CD44 IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Cancer stem cells (CSCs), or tumor-initiating cells, are involved in tumor progression and metastasis. MicroRNAs (miRNAs) regulate both normal stem cells and CSCs, and … |
CAN LIU et. al. |
| 2010 | 1 | Organ Reengineering Through Development Of A Transplantable Recellularized Liver Graft Using Decellularized Liver Matrix IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Orthotopic liver transplantation is the only available treatment for severe liver failure, but it is currently limited by organ shortage. One technical challenge that has thus far … |
BASAK E UYGUN et. al. |
| 2010 | 2 | NOD2 Stimulation Induces Autophagy in Dendritic Cells Influencing Bacterial Handling and Antigen Presentation IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Nucleotide-binding oligomerization domain–containing-2 (NOD2) acts as a bacterial sensor in dendritic cells (DCs), but it is not clear how bacterial recognition links with antigen … |
RACHEL COONEY et. al. |
| 2010 | 3 | Regeneration And Orthotopic Transplantation Of A Bioartificial Lung IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: About 2,000 patients now await a donor lung in the United States. Worldwide, 50 million individuals are living with end-stage lung disease. Creation of a bioartificial lung … |
HARALD C OTT et. al. |
| 2010 | 4 | Recognition Of Peptidoglycan From The Microbiota By Nod1 Enhances Systemic Innate Immunity IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Humans are colonized by a large and diverse bacterial flora (the microbiota) essential for the development of the gut immune system. A broader role for the microbiota as a major … |
THOMAS B CLARKE et. al. |
| 2010 | 5 | Epithelial Cell Cycle Arrest In G2/M Mediates Kidney Fibrosis After Injury IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Fibrosis is responsible for chronic progressive kidney failure, which is present in a large number of adults in the developed world. It is increasingly appreciated that acute … |
Li Yang; Tatiana Y Besschetnova; Craig R Brooks; Jagesh V Shah; Joseph V Bonventre; |
| 2010 | 6 | Real-time Imaging Reveals The Single Steps of Brain Metastasis Formation IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Brain metastasis frequently occurs in individuals with cancer and is often fatal. We used multiphoton laser scanning microscopy to image the single steps of metastasis formation … |
YVONNE KIENAST et. al. |
| 2010 | 7 | Reciprocal Coupling Of Coagulation And Innate Immunity Via Neutrophil Serine Proteases IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Blood neutrophils provide the first line of defense against pathogens but have also been implicated in thrombotic processes. This dual function of neutrophils could reflect an … |
STEFFEN MASSBERG et. al. |
| 2010 | 8 | Notch-mediated Expansion Of Human Cord Blood Progenitor Cells Capable Of Rapid Myeloid Reconstitution IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Delayed myeloid engraftment after cord blood transplantation (CBT) is thought to result from inadequate numbers of progenitor cells in the graft and is associated with increased … |
COLLEEN DELANEY et. al. |
| 2010 | 9 | Toll-like Receptor 4 And High-mobility Group Box-1 Are Involved In Ictogenesis And Can Be Targeted To Reduce Seizures IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Brain inflammation is a major factor in epilepsy, but the impact of specific inflammatory mediators on neuronal excitability is incompletely understood. Using models of acute and … |
MATTIA MAROSO et. al. |
| 2010 | 10 | Receptor-mediated Activation Of Ceramidase Activity Initiates The Pleiotropic Actions Of Adiponectin IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The adipocyte-derived secretory factor adiponectin promotes insulin sensitivity, decreases inflammation and promotes cell survival. No unifying mechanism has yet explained how … |
WILLIAM L HOLLAND et. al. |