Most Influential NATURE REVIEWS GASTROENTEROLOGY AND HEPATOLOGY Papers
Nature Reviews Gastroenterology & Hepatology aims to be the premier source of Reviews and commentaries for the scientific and medical communities. Paper Digest Team analyze all papers published on NATURE REVIEWS GASTROENTEROLOGY AND HEPATOLOGY in the past years, and presents the 10 most influential papers for each year (based on when the paper became available online). This ranking list is automatically constructed based upon citations from both research papers and granted patents, and will be frequently updated to reflect the most recent changes. To find the most influential papers from other conferences/journals, visit Best Paper Digest page. Note: the most influential papers may or may not include the papers that won the best paper awards. (Last updated on: 2021-05-23)
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TABLE 1: Most Influential NATURE REVIEWS GASTROENTEROLOGY AND HEPATOLOGY Papers
| Year | Rank | Paper | Author(s) |
|---|---|---|---|
| 2020 | 1 | The International Scientific Association for Probiotics and Prebiotics (ISAPP) Consensus Statement on The Definition and Scope of Synbiotics IF:4 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: In May 2019, the International Scientific Association for Probiotics and Prebiotics (ISAPP) convened a panel of nutritionists, physiologists and microbiologists to review the … |
KELLY S SWANSON et. al. |
| 2020 | 2 | Gut Microbiota-derived Metabolites As Key Actors In Inflammatory Bowel Disease IF:3 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: A key role of the gut microbiota in the establishment and maintenance of health, as well as in the pathogenesis of disease, has been identified over the past two decades. One of … |
Aonghus Lavelle; Harry Sokol; |
| 2020 | 3 | Management of IBD During The COVID-19 Outbreak: Resetting Clinical Priorities IF:3 Related Papers Related Patents Related Grants Related Orgs Related Experts Details |
Silvio Danese; Maurizio Cecconi; Antonino Spinelli; |
| 2020 | 4 | Epigenetics of Colorectal Cancer: Biomarker and Therapeutic Potential IF:3 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Colorectal cancer (CRC), a leading cause of cancer-related death worldwide, evolves as a result of the stepwise accumulation of a series of genetic and epigenetic alterations in … |
Gerhard Jung; Eva Hernández-Illán; Leticia Moreira; Francesc Balaguer; Ajay Goel; |
| 2020 | 5 | Gut Microbiota and Human NAFLD: Disentangling Microbial Signatures from Metabolic Disorders IF:3 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Gut microbiota dysbiosis has been repeatedly observed in obesity and type 2 diabetes mellitus, two metabolic diseases strongly intertwined with non-alcoholic fatty liver disease … |
JUDITH ARON-WISNEWSKY et. al. |
| 2020 | 6 | Role Of Oncogenic KRAS In The Diagnosis, Prognosis And Treatment Of Pancreatic Cancer IF:3 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Pancreatic ductal adenocarcinoma (PDAC) is predicted to be the second most common cause of death within the next 10 years. The prognosis for this disease is poor despite … |
Louis Buscail; Barbara Bournet; Pierre Cordelier; |
| 2020 | 7 | Cholangiocarcinoma 2020: The Next Horizon in Mechanisms and Management IF:3 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Cholangiocarcinoma (CCA) includes a cluster of highly heterogeneous biliary malignant tumours that can arise at any point of the biliary tree. Their incidence is increasing … |
JESUS M BANALES et. al. |
| 2020 | 8 | Enteric Nervous System: Sensory Transduction, Neural Circuits and Gastrointestinal Motility IF:3 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The gastrointestinal tract is the only internal organ to have evolved with its own independent nervous system, known as the enteric nervous system (ENS). This Review provides an … |
Nick J Spencer; Hongzhen Hu; |
| 2020 | 9 | Regulation Of Intestinal Lipid Metabolism: Current Concepts And Relevance To Disease IF:3 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Lipids entering the gastrointestinal tract include dietary lipids (triacylglycerols, cholesteryl esters and phospholipids) and endogenous lipids from bile (phospholipids and … |
Chih-Wei Ko; Jie Qu; Dennis D Black; Patrick Tso; |
| 2020 | 10 | Early-onset Colorectal Cancer: Initial Clues and Current Views IF:3 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Over the past several decades, the incidence of early-onset colorectal cancer (EOCRC; in patients <50 years old) has increased at an alarming rate. Although robust and ... |
LORNE J HOFSETH et. al. |
| 2019 | 1 | A Global View of Hepatocellular Carcinoma: Trends, Risk, Prevention and Management IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Hepatocellular carcinoma (HCC) is the fourth most common cause of cancer-related death worldwide. Risk factors for HCC include chronic hepatitis B and hepatitis C, alcohol … |
JU DONG YANG et. al. |
| 2019 | 2 | Global Burden Of Colorectal Cancer: Emerging Trends, Risk Factors And Prevention Strategies IF:4 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Globally, colorectal cancer (CRC) is the third most commonly diagnosed malignancy and the second leading cause of cancer death. Arising through three major pathways, including … |
NaNa Keum; Edward Giovannucci; |
| 2019 | 3 | From NASH To HCC: Current Concepts And Future Challenges IF:4 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Caloric excess and sedentary lifestyle have led to a global epidemic of obesity and metabolic syndrome. The hepatic consequence of metabolic syndrome and obesity, nonalcoholic … |
Quentin M Anstee; Helen L Reeves; Elena Kotsiliti; Olivier Govaere; Mathias Heikenwalder; |
| 2019 | 4 | Immunotherapy In Colorectal Cancer: Rationale, Challenges And Potential IF:4 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Following initial successes in melanoma treatment, immunotherapy has rapidly become established as a major treatment modality for multiple types of solid cancers, including a … |
KARUNA GANESH et. al. |
| 2019 | 5 | Probiotics And Prebiotics In Intestinal Health And Disease: From Biology To The Clinic IF:4 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Probiotics and prebiotics are microbiota-management tools for improving host health. They target gastrointestinal effects via the gut, although direct application to other sites … |
Mary Ellen Sanders; Daniel J Merenstein; Gregor Reid; Glenn R Gibson; Robert A Rastall; |
| 2019 | 6 | Molecular Subtypes of Pancreatic Cancer IF:4 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Cancers that appear morphologically similar often have dramatically different clinical features, respond variably to therapy and have a range of outcomes. Compelling evidence now … |
Eric A Collisson; Peter Bailey; David K Chang; Andrew V Biankin; |
| 2019 | 7 | Gut Microbiota In Colorectal Cancer: Mechanisms Of Action And Clinical Applications IF:3 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Colorectal cancer (CRC) accounts for about 10% of all new cancer cases globally. Located at close proximity to the colorectal epithelium, the gut microbiota comprises a large … |
Sunny H Wong; Jun Yu; |
| 2019 | 8 | Past, Present And Future Perspectives In Nonalcoholic Fatty Liver Disease IF:3 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Nonalcoholic fatty liver disease (NAFLD) was first described as a distinct clinical entity four decades ago. However, the condition has become the centre of attention within … |
Arun J Sanyal; |
| 2019 | 9 | Macrophages In Intestinal Inflammation And Resolution: A Potential Therapeutic Target In IBD IF:3 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Macrophages are the gatekeepers of intestinal immune homeostasis as they discriminate between innocuous antigens and potential pathogens to maintain oral tolerance. However, in … |
Yi Rang Na; Michelle Stakenborg; Seung Hyeok Seok; Gianluca Matteoli; |
| 2019 | 10 | Alcohol, Liver Disease And The Gut Microbiota IF:3 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Alcoholic liver disease, which ranges from mild disease to alcoholic hepatitis and cirrhosis, is a leading cause of morbidity and mortality worldwide. Alcohol intake can lead to … |
Jasmohan S Bajaj; |
| 2018 | 1 | You Are What You Eat: Diet, Health And The Gut Microbiota IF:5 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Since the renaissance of microbiome research in the past decade, much insight has accumulated in comprehending forces shaping the architecture and functionality of resident … |
Niv Zmora; Jotham Suez; Eran Elinav; |
| 2018 | 2 | Therapeutic Developments in Pancreatic Cancer: Current and Future Perspectives IF:5 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The overall 5-year survival for pancreatic cancer has changed little over the past few decades, and pancreatic cancer is predicted to be the second leading cause of cancer-related … |
JOHN P NEOPTOLEMOS et. al. |
| 2018 | 3 | Tales From The Crypt: New Insights Into Intestinal Stem Cells IF:4 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The intestinal epithelium withstands continuous mechanical, chemical and biological insults despite its single-layered, simple epithelial structure. The crypt-villus tissue … |
Helmuth Gehart; Hans Clevers; |
| 2018 | 4 | Triggering And Resolution Of Inflammation In NASH IF:4 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Nonalcoholic steatohepatitis (NASH) is considered the progressive form of nonalcoholic fatty liver disease (NAFLD) and is characterized by liver steatosis, inflammation, … |
Susanne Schuster; Daniel Cabrera; Marco Arrese; Ariel E Feldstein; |
| 2018 | 5 | Non-coding RNAs In Hepatocellular Carcinoma: Molecular Functions And Pathological Implications IF:4 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Hepatocellular carcinoma (HCC) is a leading lethal malignancy worldwide. However, the molecular mechanisms underlying liver carcinogenesis remain poorly understood. Over the past … |
Chun-Ming Wong; Felice Ho-Ching Tsang; Irene Oi-Lin Ng; |
| 2018 | 6 | The Role Of Macrophages In Nonalcoholic Fatty Liver Disease And Nonalcoholic Steatohepatitis IF:4 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Nonalcoholic fatty liver disease (NAFLD) and its inflammatory and often progressive subtype nonalcoholic steatohepatitis (NASH) are becoming the leading cause of liver-related … |
KONSTANTIN KAZANKOV et. al. |
| 2018 | 7 | Apoptosis And Necroptosis In The Liver: A Matter Of Life And Death IF:5 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Cell death represents a basic biological paradigm that governs outcomes and long-term sequelae in almost every hepatic disease condition. Acute liver failure is characterized by … |
Robert F Schwabe; Tom Luedde; |
| 2018 | 8 | Role Of Priority Effects In The Early-life Assembly Of The Gut Microbiota IF:3 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Understanding how microbial communities develop is essential for predicting and directing their future states. Ecological theory suggests that community development is often … |
Daniel Sprockett; Tadashi Fukami; David A Relman; |
| 2018 | 9 | Global Epidemiology And Holistic Prevention Of Pancreatitis IF:3 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Knowledge of pancreatitis in the 20th century was shaped predominantly by animal data and clinical trials. Several large general population-based cohort studies and comprehensive … |
Maxim S Petrov; Dhiraj Yadav; |
| 2018 | 10 | Gut Microbiota-mediated Inflammation In Obesity: A Link With Gastrointestinal Cancer IF:3 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Overweight and obesity are associated with increased risk of developing metabolic disorders such as diabetes and cardiovascular diseases. However, besides these metabolic … |
Patrice D Cani; Benedicte F Jordan; |
| 2017 | 1 | Global Burden Of NAFLD And NASH: Trends, Predictions, Risk Factors And Prevention IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: NAFLD is one of the most important causes of liver disease worldwide and will probably emerge as the leading cause of end-stage liver disease in the coming decades, with the … |
ZOBAIR YOUNOSSI et. al. |
| 2017 | 2 | Expert Consensus Document: The International Scientific Association For Probiotics And Prebiotics (ISAPP) Consensus Statement On The Definition And Scope Of Prebiotics IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: In December 2016, a panel of experts in microbiology, nutrition and clinical research was convened by the International Scientific Association for Probiotics and Prebiotics to … |
GLENN R GIBSON et. al. |
| 2017 | 3 | Mechanisms Of Hepatic Stellate Cell Activation IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Hepatic fibrosis is a dynamic process characterized by the net accumulation of extracellular matrix resulting from chronic liver injury of any aetiology, including viral … |
Takuma Tsuchida; Scott L Friedman; |
| 2017 | 4 | Gut Microbiota And IBD: Causation Or Correlation? IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: A general consensus exists that IBD is associated with compositional and metabolic changes in the intestinal microbiota (dysbiosis). However, a direct causal relationship between … |
Josephine Ni; Gary D Wu; Lindsey Albenberg; Vesselin T Tomov; |
| 2017 | 5 | Gut Microbiota Modulation Of Chemotherapy Efficacy And Toxicity IF:5 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Evidence is growing that the gut microbiota modulates the host response to chemotherapeutic drugs, with three main clinical outcomes: facilitation of drug efficacy; abrogation and … |
JAMES L ALEXANDER et. al. |
| 2017 | 6 | Environmental Triggers In IBD: A Review Of Progress And Evidence IF:4 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: A number of environmental factors have been associated with the development of IBD. Alteration of the gut microbiota, or dysbiosis, is closely linked to initiation or progression … |
ASHWIN N ANANTHAKRISHNAN et. al. |
| 2017 | 7 | Autophagy In The Liver: Functions In Health And Disease IF:4 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The concept of macroautophagy was established in 1963, soon after the discovery of lysosomes in rat liver. Over the 50 years since, studies of liver autophagy have produced many … |
Takashi Ueno; Masaaki Komatsu; |
| 2017 | 8 | Lipid Droplets And Liver Disease: From Basic Biology To Clinical Implications IF:5 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Lipid droplets are dynamic organelles that store neutral lipids during times of energy excess and serve as an energy reservoir during deprivation. Many prevalent metabolic … |
Nina L Gluchowski; Michel Becuwe; Tobias C Walther; Robert V Farese; |
| 2017 | 9 | Current And Emerging Therapeutic Targets For IBD IF:4 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: This corrects the article DOI: 10.1038/nrgastro.2016.208. … |
Markus Neurath; |
| 2017 | 10 | The Gut Microbiome And Liver Cancer: Mechanisms And Clinical Translation IF:4 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Hepatocellular carcinoma (HCC) is the third leading cause of worldwide cancer mortality. HCC almost exclusively develops in patients with chronic liver disease, driven by a … |
Le-Xing Yu; Robert F Schwabe; |
| 2016 | 1 | Expert Consensus Document: Cholangiocarcinoma: Current Knowledge And Future Perspectives Consensus Statement From The European Network For The Study Of Cholangiocarcinoma (ENS-CCA) IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Cholangiocarcinoma (CCA) is a heterogeneous group of malignancies with features of biliary tract differentiation. CCA is the second most common primary liver tumour and the … |
JESUS M BANALES et. al. |
| 2016 | 2 | Diet, Microorganisms And Their Metabolites, And Colon Cancer IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Colorectal cancer is one of the so-called westernized diseases and the second leading cause of cancer death worldwide. On the basis of global epidemiological and scientific … |
Stephen J D O’Keefe; |
| 2016 | 3 | The Role Of The Gut Microbiota In NAFLD IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: NAFLD is now the most common cause of liver disease in Western countries. This Review explores the links between NAFLD, the metabolic syndrome, dysbiosis, poor diet and gut … |
Christopher Leung; Leni Rivera; John B Furness; Peter W Angus; |
| 2016 | 4 | NAFLD And Diabetes Mellitus IF:5 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The liver constitutes a key organ in systemic metabolism, contributing substantially to the development of insulin resistance and type 2 diabetes mellitus (T2DM). The mechanisms … |
Herbert Tilg; Alexander R Moschen; Michael Roden; |
| 2016 | 5 | The Intestinal Epithelial Barrier: A Therapeutic Target? IF:5 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: A fundamental function of the intestinal epithelium is to act as a barrier that limits interactions between luminal contents such as the intestinal microbiota, the underlying … |
Matthew A Odenwald; Jerrold R Turner; |
| 2016 | 6 | Global Epidemiology And Burden Of HCV Infection And HCV-related Disease IF:5 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Chronic HCV infection is a global health problem that affects >184 million people worldwide. HCV is associated with several hepatic and extrahepatic disorders, including several … |
Aaron P Thrift; Hashem B El-Serag; Fasiha Kanwal; |
| 2016 | 7 | Understanding The Mechanisms Of Faecal Microbiota Transplantation IF:4 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: This Review summarizes mechanistic investigations in faecal microbiota transplantation (FMT), which has increasingly been adapted into clinical practice as treatment for … |
Alexander Khoruts; Michael J Sadowsky; |
| 2016 | 8 | The Bowel And Beyond: The Enteric Nervous System In Neurological Disorders IF:4 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The enteric nervous system (ENS) is large, complex and uniquely able to orchestrate gastrointestinal behaviour independently of the central nervous system (CNS). An intact ENS is … |
Meenakshi Rao; Michael D Gershon; |
| 2016 | 9 | Necrotizing Enterocolitis: New Insights Into Pathogenesis and Mechanisms IF:4 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Necrotizing enterocolitis (NEC) is the most frequent and lethal disease of the gastrointestinal tract of preterm infants. At present, NEC is thought to develop in the premature … |
Diego F Niño; Chhinder P Sodhi; David J Hackam; |
| 2016 | 10 | Clostridium Difficile Infection: Epidemiology, Diagnosis And Understanding Transmission IF:4 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Clostridium difficile infection (CDI) continues to affect patients in hospitals and communities worldwide. The spectrum of clinical disease ranges from mild diarrhoea to toxic … |
Jessica S H Martin; Tanya M Monaghan; Mark H Wilcox; |
| 2015 | 1 | The Global Burden Of IBD: From 2015 To 2025 IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Over 1 million residents in the USA and 2.5 million in Europe are estimated to have IBD, with substantial costs for health care. These estimates do not factor in the ‘real’ price … |
Gilaad G Kaplan; |
| 2015 | 2 | Epidemiology And Risk Factors For IBD IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: IBD, comprising Crohn’s disease and ulcerative colitis, is a chronic immunologically mediated disease at the intersection of complex interactions between genetics, environment and … |
Ashwin N Ananthakrishnan; |
| 2015 | 3 | Immunopathogenesis Of IBD: Current State Of The Art IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: IBD is a chronic inflammatory condition of the gastrointestinal tract encompassing two main clinical entities: Crohn’s disease and ulcerative colitis. Although Crohn’s disease and … |
Heitor S P de Souza; Claudio Fiocchi; |
| 2015 | 4 | Towards A More Comprehensive Concept For Prebiotics IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The essential role of the gut microbiota for health has generated tremendous interest in modulating its composition and metabolic function. One of these strategies is prebiotics, … |
Laure B Bindels; Nathalie M Delzenne; Patrice D Cani; Jens Walter; |
| 2015 | 5 | Alcoholic Liver Disease: Mechanisms Of Injury And Targeted Treatment IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Alcoholic liver disease (ALD) is a complex process that includes a wide spectrum of hepatic lesions, from steatosis to cirrhosis. Cell injury, inflammation, oxidative stress, … |
Alexandre Louvet; Philippe Mathurin; |
| 2015 | 6 | Inflammasome Activation And Function In Liver Disease IF:5 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Inflammation contributes to the pathogenesis of most acute and chronic liver diseases. Inflammasomes are multiprotein complexes that can sense danger signals from damaged cells … |
Gyongyi Szabo; Jan Petrasek; |
| 2015 | 7 | Immunological Landscape And Immunotherapy Of Hepatocellular Carcinoma IF:5 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Advanced hepatocellular carcinoma (HCC) is a serious therapeutic challenge and targeted therapies only provide a modest benefit in terms of overall survival. Novel approaches are … |
Jesús Prieto; Ignacio Melero; Bruno Sangro; |
| 2015 | 8 | Dysphagia: Current Reality And Scope Of The Problem IF:4 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Dysphagia is a symptom of swallowing dysfunction that occurs between the mouth and the stomach. Although oropharyngeal dysphagia is a highly prevalent condition (occurring in up … |
Pere Clavé; Reza Shaker; |
| 2015 | 9 | Biologic Agents For IBD: Practical Insights IF:4 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Six biologic agents are currently approved for the treatment of IBD: four anti-TNF agents (infliximab, adalimumab, golimumab and certolizumab pegol) and two anti-integrin agents … |
Silvio Danese; Lucine Vuitton; Laurent Peyrin-Biroulet; |
| 2015 | 10 | Software For Enhanced Video Capsule Endoscopy: Challenges For Essential Progress IF:4 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Video capsule endoscopy (VCE) has revolutionized the diagnostic work-up in the field of small bowel diseases. Furthermore, VCE has the potential to become the leading screening … |
Dimitris K Iakovidis; Anastasios Koulaouzidis; |
| 2014 | 1 | Expert Consensus Document. The International Scientific Association For Probiotics And Prebiotics Consensus Statement On The Scope And Appropriate Use Of The Term Probiotic IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: An expert panel was convened in October 2013 by the International Scientific Association for Probiotics and Prebiotics (ISAPP) to discuss the field of probiotics. It is now 13 … |
COLIN HILL et. al. |
| 2014 | 2 | A Role For The Gut Microbiota In IBS IF:5 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The past decade has witnessed an explosion of knowledge regarding the vast microbial community that resides within our intestine-the gut microbiota. The topic has generated great … |
Stephen M Collins; |
| 2014 | 3 | Mechanisms And Efficacy Of Dietary FODMAP Restriction In IBS IF:4 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: IBS is a debilitating condition that markedly affects quality of life. The chronic nature, high prevalence and associated comorbidities contribute to the considerable economic … |
Heidi M Staudacher; Peter M Irving; Miranda C E Lomer; Kevin Whelan; |
| 2014 | 4 | Neuroplasticity And Dysfunction After Gastrointestinal Inflammation IF:4 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The gastrointestinal tract is innervated by several distinct populations of neurons, whose cell bodies either reside within (intrinsic) or outside (extrinsic) the gastrointestinal … |
Stuart M Brierley; David R Linden; |
| 2014 | 5 | Exploration Of Liver Cancer Genomes IF:4 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Liver cancer is the third leading cause of cancer-related death worldwide. Advances in sequencing technologies have enabled the examination of liver cancer genomes at high … |
Tatsuhiro Shibata; Hiroyuki Aburatani; |
| 2014 | 6 | HCV And HIV Co-infection: Mechanisms And Management IF:4 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: HCV and HIV co-infection is associated with accelerated hepatic fibrosis progression and higher rates of liver decompensation and death compared to HCV monoinfection, and liver … |
Jennifer Y Chen; Eoin R Feeney; Raymond T Chung; |
| 2014 | 7 | Genetics Of Gastric Cancer IF:4 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Gastric cancer remains highly prevalent and accounts for a notable proportion of global cancer mortality. This cancer is also associated with poor survival rates. Understanding … |
Mairi H McLean; Emad M El-Omar; |
| 2014 | 8 | The Emerging Roles Of Microvesicles In Liver Diseases IF:4 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Microvesicles (MVs) are extracellular vesicles released by virtually all cells, under both physiological and pathological conditions. They contain lipids, proteins, RNAs and … |
SARA LEMOINNE et. al. |
| 2014 | 9 | Crosstalk At The Mucosal Border: Importance Of The Gut Microenvironment In IBS IF:4 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The aetiology and pathology of IBS, a functional bowel disorder thought to lack an organic cause, is largely unknown. However, studies suggest that various features, such as … |
Lena Öhman; Hans Törnblom; Magnus Simrén; |
| 2014 | 10 | Advances In IBD Genetics IF:4 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: IBD is a spectrum of chronic disorders that constitute an important health problem worldwide. The hunt for genetic determinants of disease onset and course has culminated in the … |
Johan Van Limbergen; Graham Radford-Smith; Jack Satsangi; |
| 2013 | 1 | The Global NAFLD Epidemic IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: NAFLD is a clinical syndrome characterized by predominant macrovesicular steatosis of the liver. The clinical and histological phenotypes of NAFLD extend from a nonalcoholic fatty … |
Rohit Loomba; Arun J Sanyal; |
| 2013 | 2 | Progression Of NAFLD To Diabetes Mellitus, Cardiovascular Disease Or Cirrhosis IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: NAFLD is a spectrum of progressive liver disease that encompasses simple steatosis, NASH, fibrosis and, ultimately, cirrhosis. NAFLD is recognized as the hepatic component of the … |
Quentin M Anstee; Giovanni Targher; Christopher P Day; |
| 2013 | 3 | Epidemiology And Natural History Of HCV Infection IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Worldwide, an estimated 130-170 million people have HCV infection. HCV prevalence is highest in Egypt at >10% of the general population and China has the most people with HCV … |
Behzad Hajarizadeh; Jason Grebely; Gregory J Dore; |
| 2013 | 4 | The Gastrointestinal Mucus System In Health And Disease IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Mucins–large, highly glycosylated proteins–are important for the luminal protection of the gastrointestinal tract. Enterocytes have their apical surface covered by transmembrane … |
Malin E V Johansson; Henrik Sjövall; Gunnar C Hansson; |
| 2013 | 5 | NAFLD, NASH And Liver Cancer IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: NAFLD affects a large proportion of the US population and its incidence and prevalence are increasing to epidemic proportions around the world. As with other liver diseases that … |
Gregory A Michelotti; Mariana V Machado; Anna Mae Diehl; |
| 2013 | 6 | Bile Acid Receptors As Targets For Drug Development IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The intracellular nuclear receptor farnesoid X receptor and the transmembrane G protein-coupled receptor TGR5 respond to bile acids by activating transcriptional networks and/or … |
Frank G Schaap; Michael Trauner; Peter L M Jansen; |
| 2013 | 7 | The Gut As A Sensory Organ IF:5 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The gastrointestinal tract presents the largest and most vulnerable surface to the outside world. Simultaneously, it must be accessible and permeable to nutrients and must defend … |
John B Furness; Leni R Rivera; Hyun-Jung Cho; David M Bravo; Brid Callaghan; |
| 2013 | 8 | The Genetics Of NAFLD IF:5 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: NAFLD is a disease spectrum ranging from simple steatosis, through steatohepatitis to fibrosis and, ultimately, cirrhosis. This condition is characterized by considerable … |
Quentin M Anstee; Christopher P Day; |
| 2013 | 9 | MicroRNAs In Liver Disease IF:5 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Small, noncoding microRNAs (miRNAs) regulate diverse biological functions in the liver and increasing evidence suggests that they have a role in liver pathology. This Review … |
Gyongyi Szabo; Shashi Bala; |
| 2013 | 10 | Chemopreventive Strategies In Hepatocellular Carcinoma IF:5 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Hepatocellular carcinoma (HCC) is the third most common cause of death from cancer. The incidence and mortality of HCC are increasing in most Western countries as a result of an … |
Siddharth Singh; Preet Paul Singh; Lewis R Roberts; William Sanchez; |
| 2012 | 1 | The Role Of The Gut Microbiota In Nutrition And Health IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The microbial communities that colonize different regions of the human gut influence many aspects of health. In the healthy state, they contribute nutrients and energy to the host … |
Harry J Flint; Karen P Scott; Petra Louis; Sylvia H Duncan; |
| 2012 | 2 | The Gut Microbiota In IBD IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: IBD-ulcerative colitis and Crohn’s disease-is emerging as a worldwide epidemic. An association between the increased incidence of IBD and environmental factors linked to … |
Chaysavanh Manichanh; Natalia Borruel; Francesc Casellas; Francisco Guarner; |
| 2012 | 3 | The Enteric Nervous System And Neurogastroenterology IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Neurogastroenterology is defined as neurology of the gastrointestinal tract, liver, gallbladder and pancreas and encompasses control of digestion through the enteric nervous … |
John B Furness; |
| 2012 | 4 | The Role Of Stroma In Pancreatic Cancer: Diagnostic And Therapeutic Implications IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Pancreatic ductal adenocarcinoma (PDAC) is one of the five most lethal malignancies worldwide and survival has not improved substantially in the past 30 years. Desmoplasia … |
MERT ERKAN et. al. |
| 2012 | 5 | Microbial Contact During Pregnancy, Intestinal Colonization And Human Disease IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Interaction with colonizing intestinal bacteria is essential for healthy intestinal and immunological development in infancy. Advances in understanding early host-microbe … |
Samuli Rautava; Raakel Luoto; Seppo Salminen; Erika Isolauri; |
| 2012 | 6 | Techniques Used To Characterize The Gut Microbiota: A Guide For The Clinician IF:5 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The gut microbiota is a complex ecosystem that has a symbiotic relationship with its host. An association between the gut microbiota and disease was first postulated in the early … |
Marianne H Fraher; Paul W O’Toole; Eamonn M M Quigley; |
| 2012 | 7 | Medical Therapies For Hepatocellular Carcinoma: A Critical View Of The Evidence IF:5 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The management of hepatocellular carcinoma (HCC) has substantially changed in the past few decades. Improvements in patient stratification (for example, using the Barcelona Clinic … |
Augusto Villanueva; Virginia Hernandez-Gea; Josep M Llovet; |
| 2012 | 8 | Novel Functional Roles For Enteric Glia In The Gastrointestinal Tract IF:5 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Enteric glia are a unique class of peripheral glial cells within the gastrointestinal tract. Major populations of enteric glia are found in enteric ganglia in the myenteric and … |
Brian D Gulbransen; Keith A Sharkey; |
| 2012 | 9 | New Biomarkers And Targets In Pancreatic Cancer And Their Application To Treatment IF:4 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Late diagnosis of pancreatic ductal adenocarcinoma (pancreatic cancer) and the limited response to current treatments results in an exceptionally poor prognosis. Advances in our … |
Eithne Costello; William Greenhalf; John P Neoptolemos; |
| 2012 | 10 | Contributions Of The Microbial Hydrogen Economy To Colonic Homeostasis IF:4 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Colonic gases are among the most tangible features of digestion, yet physicians are typically unable to offer long-term relief from clinical complaints of excessive gas. Studies … |
Franck Carbonero; Ann C Benefiel; H Rex Gaskins; |
| 2011 | 1 | Fecal Microbiota Transplantation And Emerging Applications IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Fecal microbiota transplantation (FMT) has been utilized sporadically for over 50 years. In the past few years, Clostridium difficile infection (CDI) epidemics in the USA and … |
Thomas J Borody; Alexander Khoruts; |
| 2011 | 2 | Epigenetics And Colorectal Cancer IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Colorectal cancer (CRC) is a leading cause of cancer deaths worldwide. It results from an accumulation of genetic and epigenetic changes in colon epithelial cells, which … |
Victoria Valinluck Lao; William M Grady; |
| 2011 | 3 | Clinical Diagnosis And Staging Of Cholangiocarcinoma IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Cholangiocarcinoma is the most frequent biliary malignancy. It is difficult to diagnose owing to its anatomic location, growth patterns and lack of definite diagnostic criteria. … |
Boris Blechacz; Mina Komuta; Tania Roskams; Gregory J Gores; |
| 2011 | 4 | The Clinical Importance Of Emerging Campylobacter Species IF:5 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: A growing number of Campylobacter species other than C. jejuni and C. coli have been recognized as emerging human and animal pathogens. Although C. jejuni continues to be the … |
Si Ming Man; |
| 2011 | 5 | The Intestinal Microbiota And Chronic Disorders Of The Gut IF:5 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Mucosal surfaces of the gut are colonized by large numbers of heterogeneous bacteria that contribute to intestinal health and disease. In genetically susceptible individuals, a … |
Andrew W DuPont; Herbert L DuPont; |
| 2011 | 6 | Hepatitis B Therapy IF:5 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The goal of hepatitis B treatment is to prevent cirrhosis, liver decompensation and hepatocellular carcinoma. In clinical practice, treatment response is determined by suppression … |
Hellan Kwon; Anna S Lok; |
| 2011 | 7 | Mechanisms Of Drug-induced Liver Injury: From Bedside To Bench IF:4 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The low incidence of idiosyncratic drug-induced liver injury (DILI), together with the lack of a reliable diagnostic biomarker and robust preclinical and in vitro toxicology test … |
Shannan Tujios; Robert J Fontana; |
| 2011 | 8 | Alcoholic Liver Disease: Pathogenesis And New Targets For Therapy IF:4 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Alcoholic liver disease (ALD) is a major cause of morbidity and mortality worldwide. The spectrum of disease ranges from fatty liver to hepatic inflammation, necrosis, progressive … |
José Altamirano; Ramón Bataller; |
| 2011 | 9 | Optimal Therapy For Helicobacter Pylori Infections IF:5 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Although Helicobacter pylori infection is both a common and a serious bacterial infection, antimicrobial therapies have rarely been optimized, are prescribed empirically, and … |
Emiko Rimbara; Lori A Fischbach; David Y Graham; |
| 2011 | 10 | The Clinical Significance Of Pancreatic Steatosis IF:4 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: More research is now focused on pancreatic steatosis. Multiple definitions, clinical associations and synonyms for pancreatic steatosis are described in the literature and can be … |
Mark M Smits; Erwin J M van Geenen; |
| 2010 | 1 | Hepatocellular Carcinoma: A Global View IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Hepatocellular carcinoma (HCC) is a global health problem, although developing countries are disproportionally affected: over 80% of HCCs occur in such regions. About … |
Ju Dong Yang; Lewis R Roberts; |
| 2010 | 2 | Probiotics And The Gut Microbiota In Intestinal Health And Disease IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The use of probiotics is increasing in popularity for both the prevention and treatment of a variety of diseases. While a growing number of well-conducted, prospective, … |
Mélanie G Gareau; Philip M Sherman; W Allan Walker; |
| 2010 | 3 | The Role Of Fructose In The Pathogenesis Of NAFLD And The Metabolic Syndrome IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Nonalcoholic fatty liver disease (NAFLD) is the most frequent liver disease worldwide, and is commonly associated with the metabolic syndrome. Secular trends in the prevalence of … |
Jung Sub Lim; Michele Mietus-Snyder; Annie Valente; Jean-Marc Schwarz; Robert H Lustig; |
| 2010 | 4 | Mechanisms Of Disease: Helicobacter Pylori Virulence Factors IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Helicobacter pylori plays an essential role in the development of various gastroduodenal diseases; however, only a small proportion of people infected with H. pylori develop these … |
Yoshio Yamaoka; |
| 2010 | 5 | Pathogenesis Of IBS: Role Of Inflammation, Immunity And Neuroimmune Interactions IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: IBS is one of the most common functional gastrointestinal disorders worldwide and is thought to be the result of disturbed neural function along the brain-gut axis. The mechanisms … |
Lena Ohman; Magnus Simrén; |
| 2010 | 6 | Evolving Challenges In Hepatic Fibrosis IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Continued elucidation of the mechanisms of hepatic fibrosis has yielded a comprehensive and nuanced portrait of fibrosis progression and regression. The paradigm of hepatic … |
Scott L Friedman; |
| 2010 | 7 | Pathology Of Nonalcoholic Fatty Liver Disease IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Nonalcoholic fatty liver disease (NAFLD) is a significant complication of obesity and is recognized as the hepatic manifestation of the metabolic syndrome. The process occurs in … |
Elizabeth M Brunt; |
| 2010 | 8 | Animal Models Of Nonalcoholic Fatty Liver Disease IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: In 1980, Ludwig and colleagues described a series of patients with liver histology characterized by the accumulation of fat and the presence of hepatic necroinflammation in the … |
Lionel Hebbard; Jacob George; |
| 2010 | 9 | The Role Of The Gut Microbiota In Nonalcoholic Fatty Liver Disease IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Important metabolic functions have been identified for the gut microbiota in health and disease. Several lines of evidence suggest a role for the gut microbiota in both the … |
Ahmed Abu-Shanab; Eamonn M M Quigley; |
| 2010 | 10 | Hypoxia: An Alarm Signal During Intestinal Inflammation IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Intestinal epithelial cells that line the mucosal surface of the gastrointestinal tract are positioned between an anaerobic lumen and a highly metabolic lamina propria. As a … |
Sean P Colgan; Cormac T Taylor; |